Protein Alignment CG42663 and NCKAP5L

DIOPT Version :9

• Sequence 1: NP_001188915.1
• Gene: CG42663 / 36403
• FlyBaseID: FBgn0261545
• Length: 662
• Species: Drosophila melanogaster
• Sequence 2: NP_001032895.2
• Gene: NCKAP5L / 57701
• HGNCID: 29321
• Length: 1334
• Species: Homo sapiens
• Alignment Length: 556
• Identity: 112/556 - (20%)
• Similarity: 157/556 - (28%)
• Gaps: 250/556 - (44%)

  Fly   134 TCRD--HKALQTRFARQESLLQSMQQENRSLLTRIRQYEHCLDDVMRKVVDAIVAEDNLREEVSM 196
            ||::  |: |:...|...:|.|:.:.:..:       ||.|||:|...||.|::.:.:||||...
Human    29 TCQELLHR-LRELEAENSALAQANENQRET-------YERCLDEVANHVVQALLNQKDLREECIK 85

  Fly   197 LKGRVRDLEAQNAALSASPVKGRDEGYCTMSSGQPQPSNGHLEDLPEEPEQWLLPAEPCSTEMED 261
            ||.||.|||.||..|||            :...:.|.:.|.|..:|..|.|  .|:||
Human    86 LKKRVFDLERQNQMLSA------------LFQQKLQLTTGSLPQIPLTPLQ--PPSEP------- 129

  Fly   262 WSMSQEELAVMTFDDERDPHHPHLQQQRRKRDHDWLWPSSDFINSTTVETDSVADGITQLLQQKI 326
                                                 |:|..::||
Human   130 -------------------------------------PASPSLSST------------------- 138

  Fly   327 VYSEDEEVACTDFTNDFYKLVNIRSNSSRSLYSYLEGETDDEDEDDDDGEDSSISESQVGPAGRI 391
                                               ||...........|:.....|.|:.|.|
Human   139 -----------------------------------EGPAAPLPLGHCAGQREVCWEQQLRPGG-- 166

  Fly   392 SPTPSEAGRAQLTSCSSSETDELSASQAKKDEEPDYAVIDECRRRVSDIEIEDVPMIVSS--TPM 454
             |.|..|....|        |.||....||      |.|.|..|.:.:.:    |:::.|  ||.
Human   167 -PGPPAAPPPAL--------DALSPFLRKK------AQILEVLRALEETD----PLLLCSPATPW 212

  Fly   455 KPLDEQQCIAQIIKSELRRPPHVLVKSKSVLEDQEPS----CILRHNQRRELESTVVCSDSISCA 515
            :|..:.....:.|..||..||           ..|||    |:|.
Human   213 RPPGQGPGSPEPINGELCGPP-----------QPEPSPWAPCLLL-------------------- 246

  Fly   516 MMNKLAKEVVPPAPGMVTKLK--ERMLLRQASTPPTASSWRRSNGWKRVTSPVHPPVAVSPKKKA 578
                        .||.:..|.  ||:|........|...|..|.|         ||        .
Human   247 ------------GPGNLGGLLHWERLLGGLGGEEDTGRPWGPSRG---------PP--------Q 282

  Fly   579 AKSTEPPKSCLPKAQPTRIPTSIHSSVSSSSSMSSSCSPSP------------------------ 619
            |:.|....:|.|.:.         ||.||..:...:.:|||
Human   283 AQGTSSGPNCAPGSS---------SSSSSDEAGDPNEAPSPDTLLGALARRQLNLGQLLEDTESY 338

  Fly   620 ------SSPSPQSPQQRSPGQQTQQQQQQQQQRKSK 649
                  .:..|.:.....|||.:...|...|..|||
Human   339 LQAFLAGAAGPLNGDHPGPGQSSSPDQAPPQLSKSK 374

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42663	NP_001188915.1	DUF3585	<111..>209	CDD:304905	28/76 (37%)
NCKAP5L	NP_001032895.2	Mediates interaction with CDK5RAP2 and is required for homodimerization and microtubule bundle formation. /evidence=ECO:0000269|PubMed:26482847, ECO:0000269|PubMed:26485573	1..139		45/229 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..28
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	115..146		13/130 (10%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	210..234		8/34 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	266..316		17/75 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	349..711		9/26 (35%)
		(S/T)X(I/L)P motif 1. /evidence=ECO:0000269|PubMed:26482847, ECO:0000269|PubMed:26485573	484..487
		Mediates interaction with beta-tubulin and is required for microtubule bundle formation. /evidence=ECO:0000269|PubMed:26482847	750..1146
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	782..884
		(S/T)X(I/L)P motif 2. /evidence=ECO:0000269|PubMed:26482847, ECO:0000269|PubMed:26485573	816..819
		NCKAP5	879..1183	CDD:291899
		(S/T)X(I/L)P motif 3, required for interaction with MAPRE1. /evidence=ECO:0000269|PubMed:26482847, ECO:0000269|PubMed:26485573	926..929
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	931..953
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	986..1015
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1030..1178
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1197..1334

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158264
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930