DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42663 and NCKAP5

DIOPT Version :9

Sequence 1:	NP_001188915.1	Gene:	CG42663 / 36403	FlyBaseID:	FBgn0261545	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	XP_005263716.1	Gene:	NCKAP5 / 344148	HGNCID:	29847	Length:	1953	Species:	Homo sapiens

Alignment Length:	830	Identity:	169/830 - (20%)
Similarity:	263/830 - (31%)	Gaps:	284/830 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 QLVHQPRTPVESEAGTLSLERHGGSISGSGGCDKDVL-------------EKRMIEV--EGALLR 94
            ||..|.|:....:.....|:|.....:..|...:.::             |||:.||  |....|
Human    38 QLEEQHRSLWREKLAVARLQREVAQRTSEGAMHEKLIHELEEERHLRLQSEKRLQEVTLESERNR 102

  Fly    95 -----LQEQFQK----------SQCGSPTFEKELREQIENMNRIMKSKERKQMQTCRDHKALQTR 144
                 ||:||.:          || |||..:||....|......:..:|||..:...|...:...
Human   103 IQMRSLQQQFSRMEETVRNLLQSQ-GSPEQKKEETVNIMVYQEKLSEEERKHKEALEDLHMVVDE 166

  Fly   145 FARQES---------------LLQSMQQENRSLL----TRIRQYEHCLDDVMRKVVDAIVAEDNL 190
            .:|.||               .|::::.||.:|.    .:..|||.|||:|..:||.|::.:.:|
Human   167 DSRSESSSTDEGKEKTKLLLERLKALEAENSALALENENQREQYERCLDEVANQVVQALLTQKDL 231

  Fly   191 REEVSMLKGRVRDLEAQNAALS------ASP-----VKGRDEGYCTMSSGQPQPSNGHLEDLPEE 244
            |||...||.||.|||.||..||      ..|     ::........:|||          ||..|
Human   232 REECVKLKTRVFDLEQQNRTLSILFQQRVRPTSDLLLQKLHSRLLDLSSG----------DLLSE 286

  Fly   245 PEQ------------------------------WLLPAEPCSTEMEDWSMSQEELAVMTFDDE-- 277
            .|:                              .::|...|......   |..||::.:...|
Human   287 VERNRSLTQSRTDAEVHEHQLNTKSALKCPGLGAVIPGHLCPRNSYS---SSSELSLSSTCSEYS 348

  Fly   278 -RDPHHPHLQQQRRKRDHDWLWPSSDFINS---------------TTVETDSVADGITQLLQQKI 326
             ...:..|..:..|||.....|.....|:|               |.::...:.:|:.:|.::|:
Human   349 SGSSYTWHDGKNLRKRQSSQNWDKRLSIDSSLPSGFASPTNELPPTRIKESHILEGLRKLQKRKV 413

  Fly   327 VYSEDEEVA------CTDFTNDFYKLVNIRSNSSRSLYSYLEGETDD------------------ 367
            :......:.      |.:.....|. ..|:|:   ||..|...:|.|
Human   414 LLEPPSVITKWGYKDCMNSNEGIYS-PGIKSS---SLKEYPPCKTADLGSPCKEPHKTFVYDLDS 474

  Fly   368 -EDEDDDDGE-------------------DSSISESQVG--------PAGRISPTPSEAGRAQLT 404
             .|.|||...                   ..|:|:|..|        ..|..|..|.|... :||
Human   475 HVDADDDPSTLALLQAVPNQSCRPHGSKLTHSVSDSLFGWETNRKHFLEGTSSVYPKERPE-KLT 538

  Fly   405 SCSSSETDEL------SASQAKKDEEP------------------DYAVIDECRRRVSDIE---- 441
            ||:||...|:      ...|.:::..|                  |....||.....||.:
Human   539 SCASSCPLEMKLCPSVQTPQVQRERGPQGQGHGRMALNLQLSDTDDNETFDELHIESSDEKSPSD 603

  Fly   442 ----------IEDVPMIV---SSTPMKPLDEQQCIAQIIKSELRRPPHVLVKSKSVL-------- 485
                      :|::.::|   .|....|.:|::.:.  |.||.|......:|.:.|:
Human   604 VSLAADTDKSVENLDVLVGFGKSLCGSPEEEEKQVP--IPSETRPKTFSFIKQQRVVKRTSSEEC 666

  Fly   486 -------EDQEPSCILRHNQRRELESTVVCSDSISCAMMNKLAKEVVPPAPGMVTKLKERMLLRQ 543
                   ||.||.....|            ...:.....|:::....|..|    |.:...||.|
Human   667 VTVIFDAEDGEPIEFSSH------------QTGVVTVTRNEISINSTPAGP----KAEHTELLPQ 715

  Fly   544 --ASTPPTASSWRRSNGWKRVTSPVHPPVAVSPKKKAAKSTEPPKSCLPKAQPTRIPTSIHSSVS 606
              |...|.|:: |....:||                   |.|..:..:||.....:|     .||
Human   716 GIACLQPRAAA-RDYTFFKR-------------------SEEDTEKNIPKDNVDNVP-----RVS 755

  Fly   607 SSSSMSSSCSPSPSSPSPQSPQQRSPGQQTQQQQQ----QQQQRKSKIPP 652
            :.|..|.:.:.:|.......|......|...:...    .|:|..:||||
Human   756 TESFSSRTVTQNPQQQKLVKPTHNISCQSNSRSSAPMGIYQKQNLTKIPP 805

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42663	NP_001188915.1	DUF3585	<111..>209	CDD:304905	36/116 (31%)
NCKAP5	XP_005263716.1	YscO	32..162	CDD:284686	30/124 (24%)
		RILP-like	32..158	CDD:304877	29/120 (24%)
		RILP-like	121..274	CDD:304877	45/153 (29%)
		NCKAP5	1468..1776	CDD:291899
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158263
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28PZH
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto88827
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4871
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.860