DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42663 and Nckap5

DIOPT Version :9

Sequence 1:	NP_001188915.1	Gene:	CG42663 / 36403	FlyBaseID:	FBgn0261545	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	XP_011246265.1	Gene:	Nckap5 / 210356	MGIID:	2686394	Length:	1972	Species:	Mus musculus

Alignment Length:	936	Identity:	179/936 - (19%)
Similarity:	293/936 - (31%)	Gaps:	369/936 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 SQGRI--QLVHQPRTPVESEAGTLSLERHGGSISGSGGCDKDVLEKRMIEV-------EGALLRL 95
            |||.:  :|:|:           |..|||....|          |:|:.||       ...:|.|
Mouse    65 SQGAMHEKLIHE-----------LEEERHLRLQS----------EERLREVTLESERNRIQMLGL 108

  Fly    96 QEQFQK----------SQCGSPTFEKELREQIENMNRIMKSKERKQMQTCRD-HKALQTRFARQE 149
            |:||.:          || |||..:||...:|......:..:|||:.....| |.......:|.|
Mouse   109 QQQFSRMEETVRSLLQSQ-GSPEQKKEEPAKITAYQEGLPDEERKEQAALGDLHVVAADEDSRSE 172

  Fly   150 -SLLQSMQQENRSLLTRIR------------------QYEHCLDDVMRKVVDAIVAEDNLREEVS 195
             |.::..::::|.||.|::                  |||.|||:|..:||.|::.:.:||||..
Mouse   173 HSSVEEGKEDSRLLLKRLKALEAENSALALENENQREQYERCLDEVANQVVRALLTQKDLREECV 237

  Fly   196 MLKGRVRDLEAQNAALS---------ASPV--KGRDEGYCTMSSGQPQPSNG------------- 236
            .||.||.|||.||.|||         ||.|  :.|......:|||......|
Mouse   238 KLKTRVFDLEQQNRALSLLFQQRVRPASDVLLQKRHSHVMALSSGDLLSEAGGSQSLALSWTDIE 302

  Fly   237 ---HLED----------------LPEEPEQWLLPAEPCSTEMEDWSMSQEELAVMTFDDERDPHH 282
               ||::                :|:.    |.|...||        |..||::.:...|.....
Mouse   303 LHEHLQNAKSGTPALKHSGSGVVIPDH----LCPRNSCS--------SGSELSLSSTCSEYSSGS 355

  Fly   283 PHLQQQRR---KRDHDWLW----------PS-----SDFINSTTVETDSVADGITQLLQQKIVYS 329
            .:..|.|:   ||....:|          ||     :|.:..|.::...:.:|:.:|.::|:...
Mouse   356 SYTWQDRKLIGKRQSSRIWDKRLSIDSSLPSGFASPADELPPTRIKESHILEGLRKLQKRKVFLE 420

  Fly   330 EDEEVA-------CTDFTNDFYKLVNIRSNSSR------------------SLYSYLEGETDDED 369
            ....|.       |.:.....|. ..|:::|.:                  ..:.|      |.:
Mouse   421 SPSLVISKWGYKDCMNSNEGIYS-PGIKTSSLKECPPCQPSGMGIPCQNLHQTFIY------DAN 478

  Fly   370 EDDDDGEDSSISESQVGPAGRISPT-PSEAGRAQ------------------------------- 402
            ..:|..|:.        |:..:..| ||:..|.|
Mouse   479 SHEDAHEEL--------PSSALPLTSPSQGYRIQGSKLTHSVSDSLFNWEPHRKYFAEGTASVYT 535

  Fly   403 ------LTSCSS-------------------------------------SETD------ELSASQ 418
                  |..|:|                                     |:||      ||....
Mouse   536 REMPERLARCASHCPLERKLCPSIHLPWVQRDRDPHSQVHGHVPLNLQLSDTDDNETLNELHIES 600

  Fly   419 AKKDEEPDYAVIDECRRRVSDIEI--------------EDVPMIVSSTP-----------MKPLD 458
            :.:....|.::..:..:.:.::|:              |..|..:.::|           :|...
Mouse   601 SDERSPSDLSLTGDTDKSMENLEVGFRKSEGGSRDMGEEACPTHLETSPKAFSFIKQQRVVKRTS 665

  Fly   459 EQQCIAQIIKSELRRPPHVLVKSKS-------VLEDQ--------EPSCILRHNQRRELESTVVC 508
            .::|:..|..:|...|    |:..|       |..|:        .||..|.....:|:......
Mouse   666 SEECVTVIFDAENGEP----VEFSSHQAGVVTVTRDEISISSALAGPSEELTELSPQEITHFQAG 726

  Fly   509 SDSISCAMMNKLAKEVVPPAP----GMVTK----LKERMLLRQASTPPTASSWRRSNGWKRVTSP 565
            :.:..|..:.:..:|.....|    .::|.    ...:.::.|.|..|..:...:...|:..:.|
Mouse   727 ATARDCPFLKRPEEETAKNIPKDENHILTAPNDFFSSQTIITQNSPRPKLAKPTQGVAWQSNSRP 791

  Fly   566 VHPPVAVSPKKKAAK-----STEPPKSCLPKAQPTRI---------------PTSIHSSVSSSSS 610
            | ..:.|..|:...|     .:.|.||.|.::.||.:               |....|....:.|
Mouse   792 V-GNMGVYTKQGLTKIPSRGKSSPQKSKLVESMPTMLVPSSALVTPEKTPASPMGKLSQCRKAES 855

  Fly   611 MSSSCSPSPSSPSPQSPQQ--------------RSPGQQTQQQQQQ------------------- 642
            ..|.|...|.|..|:.|.|              :.|..||...|.:
Mouse   856 PGSLCDVQPESHIPKHPAQVPHIPKISNKKNWVQCPRSQTSGIQSRHLMGRSDSSEMRSNGCVSA 920

  Fly   643 -QQQRKSKIPPPVP-------VRRSY 660
             |.:.:|..||..|       ||.||
Mouse   921 PQTRMRSPSPPTPPGRSVSLLVRPSY 946

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42663	NP_001188915.1	DUF3585	<111..>209	CDD:304905	37/117 (32%)
Nckap5	XP_011246265.1	SMC_prok_B	<57..>254	CDD:274008	63/210 (30%)
		PHA03247	<839..1050	CDD:223021	23/108 (21%)
		NCKAP5	1465..1767	CDD:373679
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848662
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28PZH
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto92392
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.830