DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nup188 and nup188

DIOPT Version :9

Sequence 1:	NP_001246283.1	Gene:	Nup188 / 36397	FlyBaseID:	FBgn0033766	Length:	1866	Species:	Drosophila melanogaster
Sequence 2:	XP_001923018.1	Gene:	nup188 / 559225	ZFINID:	ZDB-GENE-030131-7184	Length:	1732	Species:	Danio rerio

Alignment Length:	1844	Identity:	422/1844 - (22%)
Similarity:	746/1844 - (40%)	Gaps:	340/1844 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 KRLWPMVSGIHYETPQDTVREELMNVASELQAGVLQFKPKNASSLELGTLLKEKKQ--EKLLPFT 75
            :.||.::.|.........:.:||......|..|:..:|..:.|:.:   .||..|.  :.|..|.
Zfish    12 RELWSILLGRSALREPAQIEDELNRNWERLLQGLSFYKQPSTSAAD---KLKADKDTPQALKDFG 73

  Fly    76 ERLQDLLDLESAQCWEILCYYLTQEYRGSASLLTQLISTETNMAKLHEDIRHYYSLERMVVLKIV 140
            .|:..||.|:..|..::|..||.::|||:.:.|..::..|.....|...|..||..||:.||:.|
Zfish    74 LRISKLLGLDEQQSVQVLQCYLQEDYRGTRNTLKAVLQDERQSQALLLKIADYYYEERLCVLRCV 138

  Fly   141 KNLIVFHQVPNHPYHREYRAVVEKITIPRLRDSYLDQLESLICEVPPRKLMAGECFHSAERLVA- 204
            .:|:.:.|...|||..||...|.|:. ..|..:|..|.|:|.....|.....|...  .||.|:
Zfish   139 LHLLTYFQDERHPYRAEYSNCVSKLE-KDLVSNYRQQFETLSKSEAPTWETHGNLM--TERQVSR 200

  Fly   205 WSERNARE---INEVLHILLVLAEHLPMGLEQIKRIFAACKQHSFGKMQS---YLDDSQPYHQEI 263
            |..:..:|   :.|:|.:.....|..|..|....|:|   |:..||:.|:   .:|.|.   ..:
Zfish   201 WFVQCLKEQALLLEILFLYYAYFEMSPNDLCTFTRLF---KEQGFGQRQTNRHLVDKSM---DTL 259

  Fly   264 IRSLSY-SELMLV--------LKCLDFEKPEKH-----SDLIEKLIEDLQV--DIASMYHRPEHG 312
            :..:.| |.||||        .||...::.|:|     .|:.:::.:.|..  ||      |.||
Zfish   260 VERIGYFSSLMLVEGMDIDFLHKCALEDRTEQHQFYDQQDVCKEMDQMLLTFGDI------PHHG 318

  Fly   313 PLLLAWMLLRLRGTNDADDASSLLRCRQLGKRAVDLKCFVQLHLIARHSMYADDSMLSRIVRRTI 377
            |:||||:|  ||.|...::.||::  |:||...:.|..|..|..:.:....|.::......|..|
Zfish   319 PVLLAWVL--LRHTLRPEEVSSVI--RRLGNTTLQLGVFQYLTNMLQALGSAGNNCTVSTARMCI 379

  Fly   378 YNQVGYLCDLFDGDGSCARYEGIYELLCELVSWPHLAKDFC-SREDDGPCSLYKTLLENFPLELT 441
            |..:.::...|:.| :....:.:....||::..|.||:.|. |:.:.|...:..:.:..||.:..
Zfish   380 YGLLSFVITSFEED-TLGSQQHLINAACEVLGAPSLAELFWESKPNMGLGVILDSAVGVFPYKTG 443

  Fly   442 HLSKLALS-LTKAGQGNYVKSQLEALPILALRYDESQHKLREVDTNEFELLASVQPFQQIDFTIP 505
            .|.:|..: |:.......|.:.|:.:......|   :|:..:|.:.|...|...|..:.:   .|
Zfish   444 PLLQLLTALLSDKSTAKKVYTFLDKMSFYTEAY---KHRPNDVISREDGTLWRRQTHKLL---YP 502

  Fly   506 AGTSCTAIQHPSGCF-----------------MHFRFPVNYFDALHHEINCLLRETGHLHGDFES 553
            .|...|.::.|.|||                 :.:.:..:.:.....||..||    |:....:.
Zfish   503 LGVGQTNLRMPQGCFGQVCEGKQLSVGEQGFLVRWEYSYSSWTLFTCEIEMLL----HVVSTADV 563

  Fly   554 SERIRNVEAGLRFLESAVKLSQSISGISAEMVHPTEMCVDLLHTFKSVQYPPVGLLSSCLNVCTA 618
            ....:.|:..|..:...:....::|..   ::..|.....||....|:..|||.:::||:|...|
Zfish   564 LVHCQRVKPILDLVHKIISTDWTVSDC---LLPLTSRIYMLLQRLTSIINPPVDVITSCVNCLIA 625

  Fly   619 LLPLVDEEIFSRISNLHILPTVS-PGSHYDFKMYANANGVGFESRFLGSVIDNVEKKRERYEFLL 682
            |......:::|.:.:...||..| |.::    |....:..|.::...|:::..:|:.|..|...
Zfish   626 LAARQPAKVWSSLHHTGFLPFASTPLTN----MTQAISAEGMKAGNYGNLLVLIEQPRGEYSVT- 685

  Fly   683 SYIGFLRAYSNLKRNR----QIQMEIPGLIFLLKDVFPHLHTWHFSSQVERNKIYFEILSFICDI 743
              |.|||..:.|.:.:    |.:..||.::.:||::.|..|.|.:::...|.:|...||..:..|
Zfish   686 --IAFLRLVTTLVKGQLGSTQSRGLIPCVLLVLKEMLPTYHKWRYNTYGVRERIGCLILELVHAI 748

  Fly   744 LDLFNTAKESNCKQRELLVKVCVYSLLNLENGLILLRFVGVGNAYVQYTMELETNWMQQQPHG-- 806
            |:| |...||. .....|..:|:|||.|.|.|..::..:|||...:...:..:.:....:..|
Zfish   749 LNL-NQECESE-GSAPSLQSLCIYSLANTEAGQAVVNIMGVGVDTINMVLAAQPSSGGSEGPGQV 811

  Fly   807 LMMLVRLSMRILMQLLRLKEEVYGNSETLSPLEALIYTQPKQRDTLRIIPTVCSYMSNIFDRWLP 871
            |:..|:|:..:...::|||.:    |:|.||||..:.......:.|  |..:..|:.:..|..||
Zfish   812 LIQTVKLAFSVTNNVIRLKPQ----SDTASPLEQALTQHGGHGNNL--IAVLAKYIYHKHDPALP 870

  Fly   872 ILSCRLLKRIALQFNMSLLACLDMEADQIRLTFMQKLPDELESDSIKIAILELVDACIAKQPGVT 936
            .|:.:||||:|....||:.|||..:|..||..|:.:|....|...||:.|||.:...:..|||:.
Zfish   871 RLAIQLLKRLATVAPMSVYACLGSDAAAIRDAFLTRLQSRTEDMRIKVTILEFLTVAVETQPGLI 935

  Fly   937 EAFFKVNYALDKRSRSFFSKDCVPNIGE-SIVTYMRDFLDALQVDPLTIQQALPAKIMTIFHSMW 1000
            |.|..    |:.:..|..:|:.  ::|| |.::.:.:.||:.|.........|....:...|::|
Zfish   936 ELFLN----LETKDASDGAKEF--SLGEWSCLSVVLELLDSKQQGKYWCPPLLQRAALAFLHALW 994

  Fly  1001 KHNLQMLVDDLVKDKQFWKKLCSPLFSELQPN--------LRIYTQLLNIISIEVY--TGNGNNA 1055
            :......:..|...::||:.|.:|||..|.|.        |.....::.||::|:|  .......
Zfish   995 QDRRDSALSVLRTKEKFWENLTTPLFGNLPPPSETTEPCVLESCAFVMKIIALEIYYVVSGVLEP 1059

  Fly  1056 ALLDVMNKFFEQKNFGPWLNYVFNMPKV------PAVKNLSSSDHLPDWICCLQAFKDLIVIL-- 1112
            :|...:..|..::.:..|.:||..:..|      ..:::||.|..|      :.|::.|:::.
Zfish  1060 SLKAALESFSSKRRYEFWSDYVRELVCVACDGEEEGLRSLSESQML------ISAWRTLLILSTS 1118

  Fly  1113 ------LK----KQPKFVTIPE--SQFKLMAQK--CLVVLVDRSNYLEDMRPFIILAELYVFILL 1163
                  ||    :|..|:.:.|  ....||:|.  ||             |...::..|.:.:|.
Zfish  1119 HSEVMHLKDDTVRQKLFMDVLEGTKAALLMSQSVFCL-------------RLGSMMVTLLLILLK 1170

  Fly  1164 EFKHAYTDS--------------LEEEQTLMD---------LLL----------------QLMNR 1189
            ::|.....:              |..||.|||         |:|                ||:..
Zfish  1171 QWKSVLVSAPALLPPLSLMLESVLHAEQQLMDRTKAKLLSGLILALQIQGLNGGEISQLPQLLLC 1235

  Fly  1190 ICACYEDQHVRAKEACLAIVTKCTHLYTDLLIRDSSIALRFLNSVVGIICSELQHMENSVSLEKS 1254
            :|...:|:       .||::....|:.....:::.|:.            ::..|::
Zfish  1236 VCEMVQDE-------ALALIDSTRHMIQRGDVQEDSME------------TDSPHVQ-------- 1273

  Fly  1255 QGLNNSDSSDSKTSTNSLILCLNLLKAVATIFHNDGPGNWDLPFVSVRLFQRLVRCVSR-TLPLF 1318
                 .|..||     ..:|.|:|.|.:... ..||. .|   ...||....|...:|. .|.|.
Zfish  1274 -----KDQQDS-----VCVLALHLSKELCRA-DEDGE-QW---LQVVRKLPVLPSVLSALELSLR 1323

  Fly  1319 SKQVL-----SVQLLDVLIVFAKGHCSVEFLHCDVGEYLWLKLLPPRE--LLQSKHEFTKTTAAD 1376
            |||.|     ::.||..|....:|..:|  ....|.:.:.|.||...|  ...:...|.: ...|
Zfish  1324 SKQNLYFTEAALHLLLTLARTPQGAAAV--AGAGVIQSICLPLLSVYEGPANGANQAFVR-KCQD 1385

  Fly  1377 AEGWTVEQWWPVYARGIELVTIIYEKHKKCFLEDAFQFVGIHAVFLEDAL--LLSKQSLEPSAMY 1439
            |..|.     .||...:.|:..:.:..:..|:.:|..|||:|...:...|  :.:.|||  :.:.
Zfish  1386 APSWP-----GVYRLSLSLMESLLKTLRYNFINEALDFVGVHQERILQCLNAVRTVQSL--ACLD 1443

  Fly  1440 LIKAAVNLVASLTEHHKEWKQDSDLSLANLMRAVQSLLC----------HTSSLFH---QQKNLK 1491
            .....|..:..|:...|||:    ..|..|:|.||..||          |:..:.|   |.||.:
Zfish  1444 EADHTVGFLLQLSNFCKEWQ----FHLPQLLRDVQVNLCYLCQTCTYLLHSKKMLHHYLQAKNGE 1504

  Fly  1492 CLLAGRRSQLEILRSTEALI------VDDELISA--CNDLTDIIISCVKALLRFSPDLMELLCCS 1548
            .|..|...|..:..:::.|:      .:.:.:.|  |: |..|:...:..|..|:||..::|...
Zfish  1505 GLPQGPHPQRALQPASKELLEGEREEAESKALQAVQCS-LLKILSKTLATLQHFTPDCCQILLDQ 1568

  Fly  1549 AYEPSKHSILLDVKFGAPKLNEENLTLTFGIVLNLVNIYVKALNMQNHGFSEVPLNSLPNVEHSG 1613
            |.:.:::..|..:.|..|.. :.::..:||.::..:|:   ||:|    ..|:.....|
Zfish  1569 AMDLAEYRTLFVLSFSTPAF-DSDVAPSFGTLMATINV---ALSM----LGEIEKKKEP------ 1619

  Fly  1614 DNDDPEVCVGNQTNRTFSKPLSNVSISTGTCPASELLSNMDGQ----LCLLALEHLLMLVASQAI 1674
                                               |:|:.|.|    |.:.::|:...::.|||:
Zfish  1620 -----------------------------------LISSEDTQALKSLLMFSMENCFYVLVSQAV 1649

  Fly  1675 CIIRSPNLETLWKQIVRRDISNEL 1698
            ..::.|.:....||.:::::|:||
Zfish  1650 RCLKDPAVSHRDKQRLKQELSSEL 1673

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nup188	NP_001246283.1	Nup188	31..943	CDD:421740	246/962 (26%)
nup188	XP_001923018.1	Nup188	29..942	CDD:287461	246/967 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170577426
Domainoid	1	1.000	215	1.000	Domainoid score	I2678
eggNOG	1	0.900	-	-		E1_KOG4833
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	264	1.000	Inparanoid score	I3068
OMA	1	1.010	-	-		QHG52707
OrthoDB	1	1.010	-	-		D201834at33208
OrthoFinder	1	1.000	-	-		FOG0006520
OrthoInspector	1	1.000	-	-		oto41003
orthoMCL	1	0.900	-	-		OOG6_106099
Panther	1	1.100	-	-	LDO	PTHR31431
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4870
SonicParanoid	1	1.000	-	-		X5492
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.840