DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nup188 and Nup188

DIOPT Version :9

Sequence 1:	NP_001246283.1	Gene:	Nup188 / 36397	FlyBaseID:	FBgn0033766	Length:	1866	Species:	Drosophila melanogaster
Sequence 2:	XP_006233967.1	Gene:	Nup188 / 366016	RGDID:	1306022	Length:	1754	Species:	Rattus norvegicus

Alignment Length:	1846	Identity:	423/1846 - (22%)
Similarity:	741/1846 - (40%)	Gaps:	306/1846 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 PAVEKSVITDWKRLWPMVSGIHYETPQDTVREELMNVASELQAGVLQFKPKNASSLELGTLLKEK 66
            |.|..|     :.||.::.|.......:.:..||......|..|:..::|.:.||.|   .:|..
  Rat     8 PCVRSS-----RELWTILLGRSALRELNQIEAELNKHWQRLLEGLSYYRPPSPSSAE---RVKAN 64

  Fly    67 KQEKLLPFTE---RLQDLLDLESAQCWEILCYYLTQEYRGSASLLTQLISTETNMAKLHEDIRHY 128
            | :...|..|   |:...|.|:..|..::|..||.:.|||:...|..::..|.....|...|..|
  Rat    65 K-DVASPLKELGLRVSKFLGLDEEQSVQLLQCYLQEAYRGTRDSLKTVLQDERQSQALTLKIADY 128

  Fly   129 YSLERMVVLKIVKNLIVFHQVPNHPYHREYRAVVEKITIPRLRDSYLDQLESLICEVPPRKLMAG 193
            |..||..:|:.|.:|:.:.|...|||..||...|:|:. ..|...|..|.|.|.....|.....|
  Rat   129 YYEERTCILRCVLHLLTYFQDERHPYRAEYADCVDKLE-KELVLKYRQQFEELYRTEAPTWETHG 192

  Fly   194 ECFHSAERLVA-WSERNAREINEVLHILLVLAEHLPMGLEQIKRIFAACKQHSFGKMQS---YLD 254
            ...  .||.|: |..:..||.:.:|.|:.:...:..|....:..:....|:..||..|:   .:|
  Rat   193 NLM--TERQVSRWFVQCLREQSMLLEIIFLYYAYFEMAPSDLLVLTKMFKEQGFGSRQTNRHLVD 255

  Fly   255 DS-QPYHQEIIRSLSYSELMLVLKCLDFE---------KPEKHSDLIEKLI-EDLQVDIASMYHR 308
            :: .|:    :..:.|...:::::.:|.|         :.|.|....:.|| :|:...:.::...
  Rat   256 ETMDPF----VDRIGYFSALILVEGMDIESLHKYALDDRRELHQFAQDGLICQDMDRIMLTLGDI 316

  Fly   309 PEHGPLLLAWMLLRLRGTNDADDASSLLRCRQLGKRAVDLKCFVQLHLIARHSMYADDSMLSRIV 373
            |.|.|:||||.|  ||.|.:.::.||::  |::|..|:.|..|..|..:.|......:...:...
  Rat   317 PHHAPVLLAWAL--LRHTLNPEETSSVV--RKIGGTAIQLNVFQYLTRLLRSLASGGNDCTTSTA 377

  Fly   374 RRTIYNQVGYLCDLFDGDGSCARYEGIYELLCELVSWPHLAKDFCSRED--------DGPCSLYK 430
            ...:|..:.:.....:.. :....:.:.:..||:::.|.|.:.|...|.        |..|.::.
  Rat   378 CMCVYGLLSFALTSLELH-TLGNQQDVIDTACEVLADPSLPELFWGTEPTSGLGIILDSVCGMFP 441

  Fly   431 TLLENFPLELTHLSKLALSLTKAGQGNYVKSQLEALPILALRYDE-SQHKLREVDTNEFELLASV 494
            .||.  ||    |..|...::.......|.|.|:.:..    |:| .:||..:|.::|...|...
  Rat   442 HLLS--PL----LQLLRALVSGKSTAKKVYSFLDKMSF----YNELHKHKPHDVLSHEDGTLWRR 496

  Fly   495 QPFQ-------QIDFTIPAGTSCTAIQHPSGCFMHFRFPVNYFDALHHEINCLLRETGHLHGDFE 552
            |..:       |.:..||.||....:.......:.:.:..:.:.....||..||    |:....:
  Rat   497 QTPKLLYPLGGQTNLRIPQGTVGQVMLDDRAYLVRWEYSYSSWTLFTCEIEMLL----HVVSTAD 557

  Fly   553 SSERIRNVEAGLRFLESAVKLSQSISGISAEMVHP-TEMCVDLLHTFKSVQYPPVGLLSSCLNVC 616
            ..:..:.|:..:..:...:....||    |:.:.| |.....||....:|..|||.:::||:|..
  Rat   558 VIQHCQRVKPIIDLVHKVISTDLSI----ADCLLPITSRIYMLLQRLTTVISPPVNVIASCVNCL 618

  Fly   617 TALLPLVDEEIFSRISNLHILPTVSPGSHYDFKMYANANGVGFESRFLGSVIDNVEKKRERYEFL 681
            |.|......::::.:.:...||.|   :|....|....:..|..:...||::.|.|:.:..|...
  Rat   619 TVLAARNPAKVWTDLRHTGFLPFV---AHPVSNMTQMISAEGMNAGGYGSLLMNSEQPQGEYGVT 680

  Fly   682 LSYIGFLRAYSNLKRNR----QIQMEIPGLIFLLKDVFPHLHTWHFSSQVERNKIYFEILSFICD 742
               :.|||..:.|.:.:    |.|..:|.::|:||:|.|..|.|.:||...|..|...||..|..
  Rat   681 ---VAFLRLVTTLVKGQLGSTQSQGLVPCVMFVLKEVLPSYHKWRYSSHGVRELIGCLILELIHA 742

  Fly   743 ILDLFNTAKESNCKQREL-------LVKVCVYSLLNLENGLILLRFVGVGNAYVQYTMELETNWM 800
            ||:|        |::.||       |..:|:.||...|.|..::..:|:|...:...|..:..
  Rat   743 ILNL--------CQETELHSSHTPSLPSLCICSLAYTEAGQTVISIMGIGVDTIDMVMAAQPR-- 797

  Fly   801 QQQPHG------LMMLVRLSMRILMQLLRLKEEVYGNSETLSPLEALIYTQPKQRDTLRIIPTVC 859
            ...|.|      |:..|:|:..:...::|||..    |..:||||..:.......:.|  |..:.
  Rat   798 SDGPEGQGQGQLLIKTVKLAFSVTNNVIRLKPP----SNVVSPLEQALTQHGAHGNNL--IAVLA 856

  Fly   860 SYMSNIFDRWLPILSCRLLKRIALQFNMSLLACLDMEADQIRLTFMQKLPDELESDSIKIAILEL 924
            .|:.:..|..||.|:.:||||:|....||:.|||..:|..||..|:.:|..::|...||:.|||.
  Rat   857 KYIYHRHDPALPRLAIQLLKRLATVAPMSVYACLGSDAAAIRDAFLTRLQSKIEDMRIKVMILEF 921

  Fly   925 VDACIAKQPGVTEAFFKVNYALDKRSRSFFSKDCVPNIGE-SIVTYMRDFLDALQVDPLTIQQAL 988
            :...:..|||:.|.|..    |:.:..|..||:.  ::|. |.:..:.:.:|:.|.|.......|
  Rat   922 LTVAVETQPGLIELFLN----LEVKDGSSGSKEF--SLGVWSCLHVVLELIDSQQQDRYWCPPLL 980

  Fly   989 PAKIMTIFHSMW--KHNLQMLVDDLVKDKQFWKKLCSPLFSELQPN--------LRIYTQLLNII 1043
            ....:...|::|  :.:..|||  |....:||:.|.||||..|.|.        |.....::.||
  Rat   981 HRAAIAFLHALWQDRRDSAMLV--LRTKPRFWENLTSPLFGTLSPPSETSEPSILETCALIMKII 1043

  Fly  1044 SIEVY--TGNGNNAALLDVMNKFFEQKNFGPWLNYVFNMPKVPAVKNLSSSDHLPDWICCLQAFK 1106
            .:|:|  .....:.:|.|.:.||..:|.|..|..||.::....|....:|...|.::...:.|::
  Rat  1044 CLEIYYVVKGSLDQSLKDTLKKFSSEKRFAYWSGYVKSLAVYMAETEGNSCTSLLEYQMLVSAWR 1108

  Fly  1107 DLIVI------------LLKKQPKFVTIPESQFKLMAQKCLVVLVDRSNYLEDMRPFIILAELYV 1159
            .|:::            :..::..|:.:      |...|.|:::....|.|   |...::..|.:
  Rat  1109 TLLIVATSHADIMNLTDVAVRRQLFLDV------LDGTKALLLVATSVNCL---RLGSMMCTLLL 1164

  Fly  1160 FILLEFKHAYTDSLEEEQTLMDLLLQLMNRIC--ACYEDQHVRAKE-----ACLAIVTKCTHLYT 1217
            .:|.::|        .|...:|.:|..:..:.  ....||.:..|.     :....|.:...|..
  Rat  1165 ILLRQWK--------RELGAVDKILGPLTEVLEGVLQADQQLMEKTKAKVFSAFITVLQMKELRV 1221

  Fly  1218 DLLIRDSSIALRFLNSVVGIICSELQHMENSVSL--EKSQGLNNSDSSDSKTSTNS--------- 1271
            ..:.:.|.:.|.        :|..||  |..::|  :....|.:..:::.|.|..:
  Rat  1222 SEIPQYSQLVLN--------VCETLQ--EEVIALFDQTRHSLASGSAAEDKDSMETDDCPRPRHK 1276

  Fly  1272 -------LILCLNLLKAVATIFHNDGPGNW-----DLPF---------VSVRLFQRLVRCVSRTL 1315
                   .:|.|:|.|.:..: ..|| .:|     .||.         ||:|:.|.|
  Rat  1277 DQRDGQVCVLGLHLAKELCEV-DEDG-DSWLQVTRRLPILPTLLTTLEVSLRMKQNL-------- 1331

  Fly  1316 PLFSKQVLSVQLLDVLIVFAKGHCSVEFLHCDVGEYLWLKLLPPRELLQSKHEFTKTTAADAEGW 1380
             .|::..|  .||..|....:|..:|  ....:.:.:.|.||...:|  |.:...:|.:...:..
  Rat  1332 -HFTEAAL--HLLLTLARTQQGATAV--AGAGITQSICLPLLSVYQL--SSNGTGQTPSTSRKSL 1389

  Fly  1381 TVEQWWPVYARGIELVTIIYEKHKKCFLEDAFQFVGIHAVFLEDAL--LLSKQSLEPSAMYLIKA 1443
            ....|..||...:.|:..:.:..:..||.:|..|||:|.......|  :.:.|||  :.:.....
  Rat  1390 DAPSWPGVYRLSMSLMERLLKTLRYNFLTEALDFVGVHQERTLQCLNAVRTVQSL--ACLEEADH 1452

  Fly  1444 AVNLVASLTEHHKEWKQDSDLSLANLMRAVQ---SLLCHT-SSLFHQQKNLKCLLAGRR------ 1498
            .|..:..|:...|||    ...|..|||.||   ..||.. :||.|.:|.|:..|..:.
  Rat  1453 TVGFILQLSHFRKEW----HFHLPQLMRDVQVNLGYLCQACTSLLHSRKMLQHYLQNKNGDGLPS 1513

  Fly  1499 ----------SQLEILR-----STEALIVDDE------LISACNDLTDIIISCVKALLRFSPDLM 1542
                      :...:|.     |::..|.|.|      |.:....|..|:...:.||..|:||:.
  Rat  1514 AVTPRVHRPSTTTTVLATPSGCSSKQPIADTEASEQRALHTVQYGLLKILSRTLAALRHFTPDVC 1578

  Fly  1543 ELLCCSAYEPSKHSILLDVKFGAPKLNEENLTLTFGIVLNLVNIYVKALNMQNHGFSEVPLNSLP 1607
            ::|...:.:.::::.|..:.|..|..:.| :..:||.:|..||:   ||||         |..|.
  Rat  1579 QILLDQSLDLAEYNFLFALSFTTPTFDSE-VAPSFGTLLATVNV---ALNM---------LGELD 1630

  Fly  1608 NVEHSGDNDDPEVCVGNQTNRTFSKPLSNVSISTGTCPASELLSNMDGQLCLLALEHLLMLVASQ 1672
            ..:.|...     .||..|....::.|.:                    |.:..:|:...|:.||
  Rat  1631 KKKESLTQ-----AVGLSTQAEGTRTLKS--------------------LLMFTMENCFYLLISQ 1670

  Fly  1673 AICIIRSPNLETLWKQIVRRDISNEL 1698
            |:..:|.|.:....||.:::::|:||
  Rat  1671 AVRYLRDPAVHPRDKQRMKQELSSEL 1696

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nup188	NP_001246283.1	Nup188	31..943	CDD:421740	237/963 (25%)
Nup188	XP_006233967.1	Nup188	31..941	CDD:287461	234/961 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338069
Domainoid	1	1.000	157	1.000	Domainoid score	I4070
eggNOG	1	0.900	-	-		E1_KOG4833
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	223	1.000	Inparanoid score	I3437
OMA	1	1.010	-	-		QHG52707
OrthoDB	1	1.010	-	-		D201834at33208
OrthoFinder	1	1.000	-	-		FOG0006520
OrthoInspector	1	1.000	-	-		oto97135
orthoMCL	1	0.900	-	-		OOG6_106099
Panther	1	1.100	-	-	LDO	PTHR31431
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5492
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.810