Protein Alignment Nup188 and nup184

DIOPT Version :10

• Sequence 1: NP_001246283.1
• Gene: Nup188 / 36397
• FlyBaseID: FBgn0033766
• Length: 1866
• Species: Drosophila melanogaster
• Sequence 2: NP_593414.2
• Gene: nup184 / 2541770
• PomBaseID: SPAP27G11.10C
• Length: 1628
• Species: Schizosaccharomyces pombe
• Alignment Length: 1902
• Identity: 358/1902 - (18%)
• Similarity: 630/1902 - (33%)
• Gaps: 625/1902 - (32%)

  Fly    24 YETPQDTVR----EELMNVASELQAGVLQFKPKNASSLELGTLLKEKKQE----KL--------- 71
            :||..:.:.    |||      |.|.:..|  :...|...|||...|..|    ||
pombe    15 FETSDENLSQNKFEEL------LDARIAAF--QQIESPVTGTLNSNKTTEGEEAKLSIYDSSHSI 71

  Fly    72 ----LPFTERLQDLLDLESAQCWEILCYYLTQEYRGSASLLTQLISTETNMAKLHEDIRHYYSLE 132
                |...:::.|:.....||...:|   |..:|    .|.||..|...|.:.|.::.:..|..|
pombe    72 SKSQLESVKKISDITGYNEAQVAYVL---LVHQY----ELNTQYFSQLDNDSVLAQEFQRRYYAE 129

  Fly   133 RMVVLKIVKNLIVFHQVPNHPYHREYRAVVEKI--TIPRLRDS------------YLDQLESLIC 183
            .:...|::..|:......:..:|:....::..|  |..|..::            .:|.|..:..
pombe   130 IISCWKVLAFLLQACTDADSKWHKMATRLIVSIFQTAQRSGENAQSTTPSIFCVRIIDYLSKMTS 194

  Fly   184 EVPPRKLMAGECFHSAERLVAWSERNAREINEVLHILLVLAEHLPMGLEQIKRIF------AACK 242
            :..|..|    .|:..|.:..|                 ...|..:.|:.::.||      ..|.
pombe   195 QAAPASL----TFNGEEAISQW-----------------YFFHFNLQLQLLRVIFLSTYSLVVCN 238

  Fly   243 QHS----FGKMQS--YLDDSQPYHQEIIRSLSY-SEL--MLVLKCLDFEKPEKH----------- 287
            ...    |..|:.  ||.|.:..|.:|....|. .|:  :.::..::|...||.
pombe   239 SEMAISWFNCMKKTRYLHDQEFMHLDIDTGFSMCKEITNVAIIISINFISLEKQVLSFKDNPSFF 303

  Fly   288 ----------SDLIEKLIED-------LQVDIA--SMYHRPEHGPLLLAWMLLRLRGTNDADDAS 333
                      .|:|.:|..|       |...||  .:.:.|::.||:          .|.:..:|
pombe   304 MLSGNTIISLHDMITQLSNDSIGAAVSLTWGIALHLLSNSPDNIPLI----------QNSSVVSS 358

  Fly   334 SLLRCRQLGKRAVDLKC-----FVQLHLIARHSMYADDSML---SRIVRRTIYNQVGY------- 383
            .:|:..|...:|:.:..     |..:|.|.  |...||..:   |:|:.....:.|.|
pombe   359 KILQNPQNSFQALIIAALKYDPFTLIHRII--SSLEDDPYIDGYSKIMATLFSSAVSYVKFSDST 421

  Fly   384 -LC-----------DLFDGDGSC--------ARYEGIYELLCELVSWPHLAKDFCSREDDGPCSL 428
             ||           .||:.:.|.        ||:...|.... |:..|..|           |..
pombe   422 MLCATTLFKTPQVYQLFENNDSVTRLLNFARARFPFEYSQFV-LLLIPTFA-----------CLT 474

  Fly   429 YKTLLENFPLELTHLSKLALSLTKAGQGNYVKSQLEALPILALRYDESQHKLREVDTNEFELLAS 493
            .|.|:.:   ||.|::....||....:...:..:........:...||.|    :|:..|.
pombe   475 SKQLVSS---ELLHMTTFTQSLPSGFKAYEIIPEPNVTGNALIELQESLH----LDSYGFF---- 528

  Fly   494 VQPFQQIDFTIPAGTSCTAIQ---HPSGCFMHFRFPV-----NY--FDALHHEINCLLRETG--H 546
               |...:.::|.||....:.   :|         ||     ||  ::|:...:|.::| .|  :
pombe   529 ---FPNAERSLPKGTRGRIVSVDTYP---------PVVMWDLNYSLWEAVGISLNYIVR-NGLIN 580

  Fly   547 LHGDFESSERIRNVEAGLRFLESAVKLSQS-ISGISAEMVHPTE------------MCVDLLHTF 598
            .|..|.           |..|.|:|.|.|: :|| :.|:||...            :| |||..|
pombe   581 SHKSFV-----------LTVLSSSVPLFQTDVSG-ACELVHLASEGLDGELDFINVIC-DLLDYF 632

  Fly   599 KSVQYPPVGLLSSCLNVCTALLPLVDEEIFSRISNLHILPTVS-----PGSHYDFKM------YA 652
            .|:..    :..:...:|.:.|.|:.|  |:|.:...:...|:     .||.....:      |.
pombe   633 LSLSV----IEDADYQICVSSLRLLRE--FTRFAATDVWAYVTRSLVCVGSEKGISLEDVIFDYE 691

  Fly   653 NANGV-GFESRFLG------------SVIDNVEKKRERYEFLLSYIGFL---------RAYSNLK 695
            :.||| .|...|..            ||:.:....|.:.:|:...:.||         ..|:.:.
pombe   692 SINGVYDFTLAFFDLYEILLDNCISTSVVPDDFSIRLKTDFVKRAMRFLCEVFANYLDWKYARII 756

  Fly   696 RNRQIQMEIPGLIFLLKDV----------------------FPHLHTWHFSSQVERNKIYFEILS 738
            :..||......||..|.:|                      ..|.....|..|.:.|:....:||
pombe   757 QQYQIGHRFASLITKLLNVTFGIEYFNPKTTVNKKTLPLRELSHYIVQRFLVQQDSNRYLHPLLS 821

  Fly   739 FICDIL-----DLFNTAKESNCKQREL-LVK--------VCVYSLLNLENGLILLRFVGVGNAYV 789
             :.|::     |:|:|......|..:: |:.        :|:...|||:
pombe   822 -VMDLINLLYTDIFSTISSPRAKAAKMWLISSFCAMKTLICLRGFLNLK---------------- 869

  Fly   790 QYTMELETNWMQQQPHGLMMLVRLSMRILMQLLRLKEEVYGNSETLSPLEALIYTQPKQRDTLRI 854
              ..|||.....:.|.....|.|| :..:..:|:|             |.|||.. |...:|
pombe   870 --PSELERELFSRSPDLFNCLPRL-LCCIAPILQL-------------LSALILA-PWPSET--- 914

  Fly   855 IPTVCSYMSNIFDRWLPILSCRLLKRIALQFNMSLLACLDMEADQIRLTFMQKLPDELESDSIKI 919
             |::.:||.|..|         ::.|:.:|.                      |.:.::|.:|:.
pombe   915 -PSLLAYMINSTD---------IVGRVCIQI----------------------LTNPIQSTNIEG 947

  Fly   920 AILELVDACI-AKQPGVTEAFFK-VNYALDKRSRSFFSKDCVPNIGESIVTYMRDFLDALQVDPL 982
            ::.:.:.:.: .:|.|:....|. ..:.|| |.:|......|....:|:::.....||:..::.:
pombe   948 SVWKFLSSIMKGQQQGLAVLLFSGKKFPLD-RMKSLNHNVDVQLTSKSLISLAEKRLDSFSINDI 1011

  Fly   983 TIQQALPAKIMTIFHSMWKHNLQMLVDDLVKDKQFWKKLCS----PLFSEL-------QPNL--- 1033
             :.|....:.:.:..:.|..:|    .:|.::..||.::..    ||..:|       |.:|
pombe  1012 -LSQVPVFEFIFLSRNFWTASL----GNLQQEANFWNRIVDAIKLPLTVKLDGLSSVAQADLYIL 1071

  Fly  1034 ----------RIYTQLLN-----------------------IISIEVYTGNGNNAALLDVMNKFF 1065
                      :::...||                       ..:|..|..|.:||     :.:.|
pombe  1072 AAHATRITAIQLHMSKLNKSNSSKKIIIDPLKDSMKDLVQHAFTITAYDSNIHNA-----LTRAF 1131

  Fly  1066 EQKN-----------------FGPWLNYVFNMP------------------KVPAVKNLSSSDH- 1094
            :.:|                 :|.  ||.:|:.                  .:.|.:|||..|.
pombe  1132 KHENGDLHISDLRNTGLFPLRYGD--NYFYNIKLAKNMLLNTEDTSFKISMMMSANENLSLLDAQ 1194

  Fly  1095 ---LPDWICCLQAFKDLIVILLKKQPKFVTIPESQFKLMAQKCLVVLVDRSNYLEDMRPFIILAE 1156
               |..|...:.||.:.:     |:...::|.|.:......|.|.         ||.....::.|
pombe  1195 AALLRSWSIFICAFVEFV-----KEDATLSILELKIMKWVLKSLA---------EDTIDVNVVQE 1245

  Fly  1157 L------YVFILLEFKHAYTDSLEEEQTLMDLLLQLMNRIC----ACYEDQHVRAKEACLAIVTK 1211
            |      .||.:.:...|...|.|.::.|..:||.....|.    :.|||.:..     :|....
pombe  1246 LSAERAALVFRISQQTLAIPISNEVKEHLQSILLLTWKAITTTKFSIYEDSNGE-----MAYYRP 1305

  Fly  1212 CTHLYTDLLIRDSSIALRFLNSVVGIICSELQ--HMENSVSLEKSQGLNNSDSSDSKTSTNSLIL 1274
            ..|:..:.|.|..|.....|:..||.:...||  |.:.|...||:......:........|||..
pombe  1306 LLHVLYNTLNRLLSEEKENLSLSVGFVSGLLQLCHRKLSQLFEKAVINPTIEVYGDIVLLNSLHK 1370

  Fly  1275 CL---NLLKAVATIFHNDGPGNWDLPFVS--------VRLFQRLVRCVSRTLPLFSKQVLSVQLL 1328
            |:   :|::.:.:::         :.:::        :|||......:....|.|:...||
pombe  1371 CIVNSHLIRGLQSLY---------ISYINDSFSVDNCLRLFSWSHSLLVDGQPYFADAALS---- 1422

  Fly  1329 DVLIVFAKGHCSVEFLHCDVGEYLWLKLLPPRELLQSKHEFTKTTAADAEGWTVEQWWPVYARGI 1393
             .|::.:......|.:..: |.:..:...|....|       .|.....:|.:::  :.::.|||
pombe  1423 -FLLICSSSPAGAEQIVMN-GFFYSIMESPLSTAL-------STGGLGLDGSSIQ--YKIWIRGI 1476

  Fly  1394 -----ELVTIIYEKHKKCFLEDAFQFVGIHAVFLEDALLLSKQSLEPSAMYLIKAAVNLVASLTE 1453
                 .:|..:..:    .:.|..:||.:....::.|||
pombe  1477 LPLLFNIVKFLGNR----IMNDMREFVLLAFPQIQYALL-------------------------- 1511

  Fly  1454 HHKEWKQ-DSDLSLANLMRAVQSLLCHTSSLFH--QQKNLKCLLAGRRSQLEILRSTEALIVDDE 1515
               .|.| .|.:|||::..:...:|     ||.  ||.|...|...|.::|:|    |.|...|.
pombe  1512 ---NWCQPPSSISLASIDESFMIVL-----LFDLLQQFNPALLQEIRLAELKI----EMLEGIDY 1564

  Fly  1516 LISACNDLTDIIISCVKALLRFSPDLMELLCCSAYEPSKHSILLDVKFGAPK------LNEENLT 1574
            |||..|.|:.:.|.                 .|.||   ....:|| .|.||      |.:|..|
pombe  1565 LISHPNFLSSLAIP-----------------ASLYE---QEYAIDV-IGIPKELESDQLTKETKT 1608

  Fly  1575 LTFGIVLNLVNIYVKAL 1591
            ..|..::.:....::||
pombe  1609 SQFAKLIRIQLDKLRAL 1625

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nup188	NP_001246283.1	Nup192	31..943	CDD:475157	212/1122 (19%)
nup184	NP_593414.2	Nup192	19..972	CDD:475157	212/1124 (19%)
		Nup188_C	1277..>1488	CDD:436451	43/239 (18%)