Protein Alignment Nup188 and NUP188

DIOPT Version :9

• Sequence 1: NP_001246283.1
• Gene: Nup188 / 36397
• FlyBaseID: FBgn0033766
• Length: 1866
• Species: Drosophila melanogaster
• Sequence 2: NP_056169.1
• Gene: NUP188 / 23511
• HGNCID: 17859
• Length: 1749
• Species: Homo sapiens
• Alignment Length: 1937
• Identity: 442/1937 - (22%)
• Similarity: 784/1937 - (40%)
• Gaps: 363/1937 - (18%)

  Fly     2 PAVEKSVITDWKRLWPMVSGIHYETPQDTVREELMNVASELQ-------AGVLQFKPKNASSLEL 59
            |.|..|     :.||.::.|      :..:| ||..:.:||.       .|:..:||.:.||.|
Human     8 PCVRSS-----RELWTILLG------RSALR-ELSQIEAELNKHWRRLLEGLSYYKPPSPSSAE- 59

  Fly    60 GTLLKEKKQEKLL-PFTE---RLQDLLDLESAQCWEILCYYLTQEYRGSASLLTQLISTETNMAK 120
                |.|..:.:. |..|   |:...|.|:..|..::|..||.::|||:...:..::..|.....
Human    60 ----KVKANKDVASPLKELGLRISKFLGLDEEQSVQLLQCYLQEDYRGTRDSVKTVLQDERQSQA 120

  Fly   121 LHEDIRHYYSLERMVVLKIVKNLIVFHQVPNHPYHREYRAVVEKITIPRLRDSYLDQLESLICEV 185
            |...|..||..||..:|:.|.:|:.:.|...|||..||...|:|:. ..|...|..|.|.|....
Human   121 LILKIADYYYEERTCILRCVLHLLTYFQDERHPYRVEYADCVDKLE-KELVSKYRQQFEELYKTE 184

  Fly   186 PPRKLMAGECFHSAERLVA-WSERNAREINEVLHILLVLAEHLPMGLEQIKRIFAACKQHSFGKM 249
            .|.....|...  .||.|: |..:..||.:.:|.|:.:...:..|....:..:....|:..||..
Human   185 APTWETHGNLM--TERQVSRWFVQCLREQSMLLEIIFLYYAYFEMAPSDLLVLTKMFKEQGFGSR 247

  Fly   250 QS---YLDDS-QPYHQEIIRSLSYSELMLVLKCLDFE---------KPEKHSDLIEKLI-EDLQV 300
            |:   .:|:: .|:    :..:.|...:::::.:|.|         :.|.|....:.|| :|:..
Human   248 QTNRHLVDETMDPF----VDRIGYFSALILVEGMDIESLHKCALDDRRELHQFAQDGLICQDMDC 308

  Fly   301 DIASMYHRPEHGPLLLAWMLLRLRGTNDADDASSLLRCRQLGKRAVDLKCFVQLHLIARHSMYAD 365
            .:.:....|.|.|:||||.|  ||.|.:.::.||::  |::|..|:.|..|..|..:.:......
Human   309 LMLTFGDIPHHAPVLLAWAL--LRHTLNPEETSSVV--RKIGGTAIQLNVFQYLTRLLQSLASGG 369

  Fly   366 DSMLSRIVRRTIYNQVGYLCDLFDGDGSCARYEGIYELLCELVSWPHLAKDFCSRED-------- 422
            :...:......:|..:.::....:.. :....:.|.:..||:::.|.|.:.|...|.
Human   370 NDCTTSTACMCVYGLLSFVLTSLELH-TLGNQQDIIDTACEVLADPSLPELFWGTEPTSGLGIIL 433

  Fly   423 DGPCSLYKTLLENFPLELTHLSKLALSLTKAGQGNYVKSQLEALPILALRYDE-SQHKLREVDTN 486
            |..|.::..||.  ||    |..|...::.......|.|.|:.:..    |:| .:||..:|.::
Human   434 DSVCGMFPHLLS--PL----LQLLRALVSGKSTAKKVYSFLDKMSF----YNELYKHKPHDVISH 488

  Fly   487 EFELLASVQPFQ-------QIDFTIPAGTSCTAIQHPSGCFMHFRFPVNYFDALHHEINCLLRET 544
            |...|...|..:       |.:..||.||....:.......:.:.:..:.:.....||..||
Human   489 EDGTLWRRQTPKLLYPLGGQTNLRIPQGTVGQVMLDDRAYLVRWEYSYSSWTLFTCEIEMLL--- 550

  Fly   545 GHLHGDFESSERIRNVEAGLRFLESAVKLSQSISGISAEMVHP-TEMCVDLLHTFKSVQYPPVGL 608
             |:....:..:..:.|:..:..:...:....||    |:.:.| |.....||....:|..|||.:
Human   551 -HVVSTADVIQHCQRVKPIIDLVHKVISTDLSI----ADCLLPITSRIYMLLQRLTTVISPPVDV 610

  Fly   609 LSSCLNVCTALLPLVDEEIFSRISNLHILPTVS-PGSHYDFKMYA---NANGVGFESRFLGSVID 669
            ::||:|..|.|......::::.:.:...||.|: |.|.....:.|   ||.|       .|:::.
Human   611 IASCVNCLTVLAARNPAKVWTDLRHTGFLPFVAHPVSSLSQMISAEGMNAGG-------YGNLLM 668

  Fly   670 NVEKKRERYEFLLSYIGFLRAYSNLKRNR----QIQMEIPGLIFLLKDVFPHLHTWHFSSQVERN 730
            |.|:.:..|...   |.|||..:.|.:.:    |.|..:|.::|:||::.|..|.|.::|...|.
Human   669 NSEQPQGEYGVT---IAFLRLITTLVKGQLGSTQSQGLVPCVMFVLKEMLPSYHKWRYNSHGVRE 730

  Fly   731 KIYFEILSFICDILDLFNTAKESNCKQREL-------LVKVCVYSLLNLENGLILLRFVGVGNAY 788
            :|...||..|..||:|        |.:.:|       |..:|:.||...|.|..::..:|:|...
Human   731 QIGCLILELIHAILNL--------CHETDLHSSHTPSLQFLCICSLAYTEAGQTVINIMGIGVDT 787

  Fly   789 VQYTMELE--TNWMQQQPHGLMML--VRLSMRILMQLLRLKEEVYGNSETLSPLEALIYTQPKQR 849
            :...|..:  ::..:.|..|.:::  |:|:..:...::|||..    |..:||||..:.......
Human   788 IDMVMAAQPRSDGAEGQGQGQLLIKTVKLAFSVTNNVIRLKPP----SNVVSPLEQALSQHGAHG 848

  Fly   850 DTLRIIPTVCSYMSNIFDRWLPILSCRLLKRIALQFNMSLLACLDMEADQIRLTFMQKLPDELES 914
            :.|  |..:..|:.:..|..||.|:.:||||:|....||:.|||..:|..||..|:.:|..::|.
Human   849 NNL--IAVLAKYIYHKHDPALPRLAIQLLKRLATVAPMSVYACLGNDAAAIRDAFLTRLQSKIED 911

  Fly   915 DSIKIAILELVDACIAKQPGVTEAFFKVNYALDKRSRSFFSKDCVPNIGE-SIVTYMRDFLDALQ 978
            ..||:.|||.:...:..|||:.|.|..    |:.:..|..||:.  ::|. |.:..:.:.:|:.|
Human   912 MRIKVMILEFLTVAVETQPGLIELFLN----LEVKDGSDGSKEF--SLGMWSCLHAVLELIDSQQ 970

  Fly   979 VDPLTIQQALPAKIMTIFHSMW--KHNLQMLVDDLVKDKQFWKKLCSPLFSELQPN--------L 1033
            .|.......|....:...|::|  :.:..|||  |....:||:.|.||||..|.|.        |
Human   971 QDRYWCPPLLHRAAIAFLHALWQDRRDSAMLV--LRTKPKFWENLTSPLFGTLSPPSETSEPSIL 1033

  Fly  1034 RIYTQLLNIISIEVY--TGNGNNAALLDVMNKFFEQKNFGPWLNYVFNMPKVPAVKNLSSSDHLP 1096
            .....::.||.:|:|  .....:.:|.|.:.||..:|.|..|..||.::....|....||...|.
Human  1034 ETCALIMKIICLEIYYVVKGSLDQSLKDTLKKFSIEKRFAYWSGYVKSLAVHVAETEGSSCTSLL 1098

  Fly  1097 DWICCLQAFKDLIVI-------------LLKKQ---------PKFVTIPESQ--FKLMAQKCLVV 1137
            ::...:.|::.|::|             ::::|         ...:.:|.|.  .:|.:.||.::
Human  1099 EYQMLVSAWRMLLIIATTHADIMHLTDSVVRRQLFLDVLDGTKALLLVPASVNCLRLGSMKCTLL 1163

  Fly  1138 LVDRSNYLEDMRPFIILAELYVFILLEFKHAYTDSLEEEQTLMDLLLQLMNRICACYEDQHVRAK 1202
            |:                     :|.::|.. ..|::|   ::..|.:::..:...  ||.:..|
Human  1164 LI---------------------LLRQWKRE-LGSVDE---ILGPLTEILEGVLQA--DQQLMEK 1201

  Fly  1203 EACLAIVTKC---THLYTDLLIRDSSIA-LRFLNSVVGIICSELQHM------ENSVSLEKSQGL 1257
                   ||.   :...|.|.:::..:: :...:.:|..:|..||..      :...||......
Human  1202 -------TKAKVFSAFITVLQMKEMKVSDIPQYSQLVLNVCETLQEEVIALFDQTRHSLALGSAT 1259

  Fly  1258 NNSDSSDSKTSTNS---------LILCLNLLKAVATIFHNDGPGNW-----DLPF---------V 1299
            .:.||.::...:.|         .:|.|:|.|.:..: ..|| .:|     .||.         |
Human  1260 EDKDSMETDDCSRSRHRDQRDGVCVLGLHLAKELCEV-DEDG-DSWLQVTRRLPILPTLLTTLEV 1322

  Fly  1300 SVRLFQRLVRCVSRTLPLFSKQVLSVQLLDVLIVFAKGHCSVEFLHCDVGEYLWLKLLPPRELLQ 1364
            |:|:.|.|         .|::..|  .||..|....:|..:|  ....:.:.:.|.||...:|
Human  1323 SLRMKQNL---------HFTEATL--HLLLTLARTQQGATAV--AGAGITQSICLPLLSVYQL-- 1372

  Fly  1365 SKHEFTKTTAADAEGWTVEQWWPVYARGIELVTIIYEKHKKCFLEDAFQFVGIHAVFLEDAL--L 1427
            |.:...:|.:|..:......|..||...:.|:..:.:..:..||.:|..|||:|.......|  :
Human  1373 STNGTAQTPSASRKSLDAPSWPGVYRLSMSLMEQLLKTLRYNFLPEALDFVGVHQERTLQCLNAV 1437

  Fly  1428 LSKQSLEPSAMYLIKAAVNLVASLTEHHKEWKQDSDLSLANLMRAVQ---SLLCHT-SSLFHQQK 1488
            .:.|||  :.:......|..:..|:...|||    ...|..|||.:|   ..||.. :||.|.:|
Human  1438 RTVQSL--ACLEEADHTVGFILQLSNFMKEW----HFHLPQLMRDIQVNLGYLCQACTSLLHSRK 1496

  Fly  1489 NLKCLL------------------------AGRRSQLEILRSTEALIVDDELISACNDLTDIIIS 1529
            .|:..|                        |...|..:....||| .....|.:....|..|:..
Human  1497 MLQHYLQNKNGDGLPSAVAQRVQRPPSAASAAPSSSKQPAADTEA-SEQQALHTVQYGLLKILSK 1560

  Fly  1530 CVKALLRFSPDLMELLCCSAYEPSKHSILLDVKFGAPKLNEENLTLTFGIVLNLVNIYVKALNMQ 1594
            .:.||..|:||:.::|...:.:.::::.|..:.|..|..:.| :..:||.:|..||:   ||||
Human  1561 TLAALRHFTPDVCQILLDQSLDLAEYNFLFALSFTTPTFDSE-VAPSFGTLLATVNV---ALNM- 1620

  Fly  1595 NHGFSEVPLNSLPNVEHSGDNDDPEVCVGNQTNRTFSKPLSN-VSIST---GTCPASELLSNMDG 1655
                             .|:.|..:            :||:. |.:||   ||.....||
Human  1621 -----------------LGELDKKK------------EPLTQAVGLSTQAEGTRTLKSLL----- 1651

  Fly  1656 QLCLLALEHLLMLVASQAICIIRSPNLETLWKQIVRRDISNELLIFNEFVRRKVILDYKENRSPW 1720
               :..:|:...|:.|||:..:|.|.:....||.:::::|:||         ..:|   .:.|.:
Human  1652 ---MFTMENCFYLLISQAMRYLRDPAVHPRDKQRMKQELSSEL---------STLL---SSLSRY 1701

  Fly  1721 LRRKHGLCKLKCVDPVRSSSSSSRSSEIVRRSNTNNELRVNVVRRL--HLQQ 1770
            .||.........|.|    |...:|:.:.:.|..:.|..:.:|:..  |:|:
Human  1702 FRRGAPSSPATGVLP----SPQGKSTSLSKASPESQEPLIQLVQAFVRHMQR 1749

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nup188	NP_001246283.1	Nup188	31..943	CDD:421740	238/973 (24%)
NUP188	NP_056169.1	Nup188	31..941	CDD:402215	236/972 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1514..1542		5/28 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1707..1733		5/29 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144352
Domainoid	1	1.000	201	1.000	Domainoid score	I3014
eggNOG	1	0.900	-	-		E1_KOG4833
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	269	1.000	Inparanoid score	I3024
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52707
OrthoDB	1	1.010	-	-		D201834at33208
OrthoFinder	1	1.000	-	-		FOG0006520
OrthoInspector	1	1.000	-	-		oto90020
orthoMCL	1	0.900	-	-		OOG6_106099
Panther	1	1.100	-	-	LDO	PTHR31431
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4870
SonicParanoid	1	1.000	-	-		X5492
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.840