DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nup188 and nup188

DIOPT Version :9

Sequence 1:NP_001246283.1 Gene:Nup188 / 36397 FlyBaseID:FBgn0033766 Length:1866 Species:Drosophila melanogaster
Sequence 2:NP_001107292.1 Gene:nup188 / 100135081 XenbaseID:XB-GENE-5933085 Length:1739 Species:Xenopus tropicalis


Alignment Length:1825 Identity:429/1825 - (23%)
Similarity:757/1825 - (41%) Gaps:295/1825 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 KRLWPMVSGIHYETPQDTVREELMNVASELQAGVLQFKPKNASSLELGTLLKEKKQEKLLPFTE- 76
            :.||.::.|.........::.||......|..|:..::|.:.||..     |.|..:.|.|..: 
 Frog    13 RELWTILLGRSSMKDGHQIKAELDRYGDRLLQGLAYYRPPSTSSTG-----KVKANKNLSPALQE 72

  Fly    77 ---RLQDLLDLESAQCWEILCYYLTQEYRGSASLLTQLISTETNMAKLHEDIRHYYSLERMVVLK 138
               ||...|.|:..|..|:|..||..:|||:...:..:...|.....|...:..||..||:.:|:
 Frog    73 LGLRLSKFLGLDEEQSVELLQTYLLYDYRGTQESVKGVPQDERQSQALMLKMVDYYYEERISLLR 137

  Fly   139 IVKNLIVFHQVPNHPYHREYRAVVEKITIPRLRDSYLDQLESLICEVPPRKLMAGECFHSAERLV 203
            .|..::.:.|...|||..|:...||.:....|...||.|.|||..|..|.....|. |.:..::.
 Frog   138 CVLYILNYFQDDKHPYSAEFSKCVEMMEQKELFGKYLKQFESLCREEAPTWETHGN-FMTERQVS 201

  Fly   204 AWSERNARE---INEVLHILLVLAEHLPMGLEQIKRIFAACKQHSFG-KMQS-YLDDSQPYHQEI 263
            .|..:..||   :.|::.:........|..|..:.::|   |:..|| ::|: :|  .:|....:
 Frog   202 RWFVQRLREQAMLLEIIFLYFACFAASPSDLLALTKLF---KEQGFGCRLQNRHL--VEPSMDPL 261

  Fly   264 IRSLSYSELMLVLKCLDFE---------KPEKH---SDLIEKLIEDLQVDIASMYHRPEHGPLLL 316
            :..:.|..:::.|:.||.|         |.|:|   |:  |::.:::...:.::...|.|||:||
 Frog   262 VERIGYFSVLIFLEALDIETLMTCSLSDKTEQHPFSSE--EQVCKEMDSVLVTLGDAPHHGPVLL 324

  Fly   317 AWMLLRLRGTNDADDASSLLRCRQLGKRAVDLKCFVQLHLIARHSMYADDSMLSRIVRRTIYNQV 381
            ||.|||.  ..:||..:..:  |::|..|:.|..|..|..:.:.....:::..:......:|..:
 Frog   325 AWALLRF--ALNADKVTPTV--RKMGSTAIQLHIFQYLTRMLQSLRSGENNCTTSTACLCVYTFL 385

  Fly   382 GYLCDLFDGDGSCARYEGIYELLCELVSWPHLAKDFCSREDDGPCSLYKTLLEN----FPLELTH 442
            .::....: :......:.:.:...::.:.|:|...|.:.|   |.:....||::    ||..|:.
 Frog   386 TFVLTNLE-EQVLQSQQDLVDTAFQVFAAPNLPDLFWNME---PTAGLGILLDSVVGMFPFHLSP 446

  Fly   443 LSKLALSLTKAGQGNYVKSQLEALPILALRYDESQHKLREVDTNEFELLASVQP--------FQQ 499
            |.||..:|........|.|.|:.:......|   :||..::.::|.|.|...|.        ..|
 Frog   447 LLKLFTALVSKSSAKKVYSFLDRMSSYTEHY---RHKPHDILSHEDETLWKRQTPKVLYALGLGQ 508

  Fly   500 IDFTIPAGTSCTAIQHPSGCFMHFRFPVNYFDALHHEINCLLRETGHLHGDFESSERIRNVEAGL 564
            .:..||.||....:....|..:.:.:..:.:.....||..||    |:....:...:.:.|:..:
 Frog   509 TNLRIPQGTIGQVMADEHGFLVRWEYSYSCWTLFTCEIEMLL----HVVSTADVIHQCQRVKPII 569

  Fly   565 RFLESAVKLSQSISGISAEMVHP-TEMCVDLLHTFKSVQYPPVGLLSSCLNVCTALLPLVDEEIF 628
            ..:...:....||    |:.:.| |.....||....:|..||:..||||::...||...:..:::
 Frog   570 DLVHKVISTDLSI----ADCLLPITSRIYMLLQRLTTVMNPPMDFLSSCVDCLAALATRMPAKVW 630

  Fly   629 SRISNLHILP-TVSPGS-HYDFKMYANANGVGFESRFLGSVIDNVEKKRERYEFLLSYIGFLRAY 691
            ..:.:...|| ..:|.| |.......||.|.|  |.|      .:|:.:..|...||   |||..
 Frog   631 IDLRHTGFLPFAANPVSGHIISTEGMNAGGYG--SLF------GIEQSQGEYSITLS---FLRLV 684

  Fly   692 SNLKRNR----QIQMEIPGLIFLLKDVFPHLHTWHFSSQVERNKIYFEILSFICDILDLFNTAKE 752
            :.|.:.:    |.|..:|.::|:|:::.|:.|.|.::|...|.::.|:|||.|..||:|....:|
 Frog   685 TTLVKGQLGSTQSQGLVPCILFVLREMLPNYHRWRYNSHGVREQLGFQILSLIHAILNLSPEEEE 749

  Fly   753 SNCKQRELLVKVCVYSLLNLENGLILLRFVGVGNAYVQYTM--ELETNWMQQQPHGLMMLVRLSM 815
            |.....  |..:|::||.|.|.|..::..:|||...:...|  :..::..:.|...||..::|:.
 Frog   750 STSTPN--LQSLCIFSLTNTEAGQAVINIMGVGVDTLNAVMLTQAGSSGTEGQGQMLMQTIKLAF 812

  Fly   816 RILMQLLRLKEEVYGNSETLSPLEALIYTQPKQRDTLRIIPTVCSYMSNIFDRWLPILSCRLLKR 880
            .|...::|||.    .|..:||||..:.......:.|  |..:..|:.:.:|..||.|:.:||||
 Frog   813 SITNNVIRLKP----LSSAISPLEHALTQHGAHGNNL--IAVLAKYIYHKYDPSLPRLAIQLLKR 871

  Fly   881 IALQFNMSLLACLDMEADQIRLTFMQKLPDELESDSIKIAILELVDACIAKQPGVTEAFFKVNYA 945
            :|:...||:.|||..:|..||..|:.:|.|.:|...|||.|||.:...:..|||:.|.|..    
 Frog   872 LAMVAPMSVYACLGSDAAAIRDAFLSRLRDNIEDMQIKIMILEFLTVAVETQPGLIELFLN---- 932

  Fly   946 LDKRSRSFFSKDCVPNIGE-SIVTYMRDFLDALQVD-----PLTIQQALPAKIMTIFHSMWKHNL 1004
            |:.:..:..||:.  ::|| |.:..:...:|:...:     ||..:.|:     ...|::|:...
 Frog   933 LEVKDTNEGSKEY--SLGEWSCLQVVLKLIDSQDPESSWGAPLLHRSAI-----AFLHALWQDRR 990

  Fly  1005 QMLVDDLVKDKQFWKKLCSPLFSELQ-PN-------LRIYTQLLNIISIEVYTG-NGN-NAALLD 1059
            ...:..|.....||:.|.||||..|. |:       |.....::.||.:|:|.. .|: ..:|..
 Frog   991 DSAMTVLRTKPNFWENLTSPLFGTLAFPSESSELSILETCAFIMKIICLEIYYAVRGSLGDSLKK 1055

  Fly  1060 VMNKFFEQKNFGPWLNYVFNMPKVPAVKNLSSSDHLPDWICCLQAFK-DLIVILLKKQPKFVTIP 1123
            ::.||.|::.|..|.|||.:: .....::..:.:.|.::...|.|:: .|:|.........:|.|
 Frog  1056 ILKKFSEEERFTYWSNYVHSL-VCQVAESEGACNSLTEYQQLLSAWRMFLMVATHNADVMHLTNP 1119

  Fly  1124 ESQFKL----MAQKCLVVLVDRSN---YLEDMRPFIILAELYVFILLEFKHAYTDSLEEEQTLMD 1181
            |.:.||    :.....::||.||.   :|..|     |..:.:.:|..:|    ..|...:.::.
 Frog  1120 EVRQKLFKDVLGGTQALLLVPRSMTCLHLGSM-----LCTVMIILLRRWK----SDLAAPEDILS 1175

  Fly  1182 LLLQLMNRICACYEDQHV--RAKEACLAIVTKCTHL----------YTDLLIRDSSIALRFLNSV 1234
            .|.|::..:  ..:||.:  :.|....|.:.....:          |..|::.            
 Frog  1176 SLTQILEGV--LQKDQQLVEKTKARVFAALISALEIKPMKASEIPQYPQLVLN------------ 1226

  Fly  1235 VGIICSELQHMENSVSL--EKSQGLNNSDSSDSKTSTNS---------------LILCLNLLKAV 1282
               :|..||  |..|.|  ...|.:..:|:|:.|.|..:               .:|.|:|.|.:
 Frog  1227 ---VCETLQ--EEVVFLVDHTRQEVPANDASEDKDSMETEDTGRIRQKDQRDGVCVLGLHLAKGL 1286

  Fly  1283 ATIFHNDGPGN-WD--------LPF------VSVRLFQRLVRCVSRTLPLFSKQVLSVQLLDVLI 1332
            .   ..|..|: |.        ||.      ||:|:.|.|..|.:              :|..|.
 Frog  1287 C---EADEEGDQWQQVLRKLPVLPMLFSALEVSLRIKQNLHFCEA--------------ILHFLF 1334

  Fly  1333 VFAKGH-CSVEFLHCDVGEYLWLKLLPPRELLQSKHEFTKTTAADAEGWTVEQWWPVYARGIELV 1396
            ..||.| .:.......|.:.:.|.||...:|..:.....:...:..:......|..||...:.|:
 Frog  1335 TLAKTHQGAAAMAGAGVTQTVCLPLLSVYQLSSNGASTAQPALSLRKSLDAPSWPGVYRLTVSLM 1399

  Fly  1397 TIIYEKHKKCFLEDAFQFVGIHAVFLEDALL--LSKQSLEPSAMYLIKA--AVNLVASLTEHHKE 1457
            ..:.:..:..||.:|..|||:|    ::.:|  |......||...|.:|  .|..:..|:...||
 Frog  1400 ERLLKTLRYNFLTEALDFVGVH----QERILQCLGAVRTVPSLACLEEADHTVGFLLQLSNFTKE 1460

  Fly  1458 WKQDSDLSLANLMRAVQSLLCH----TSSLFHQQKNLKCLLAGRRSQLEILRST----------- 1507
            |    ...|..|::.||..||:    .:||.|.:|.|:..|..:..  |.:.||           
 Frog  1461 W----HFHLPQLIKDVQVNLCYLCQACTSLLHSRKMLQHYLQIKNG--ETMSSTATPRGQRTPQT 1519

  Fly  1508 ---------EALIVDDELISACNDLTDIIISCVKALLRFSPDLMELLCCSAYEPSKHSILLDVKF 1563
                     |||.: .:|.|..:.|..|:...:..|..|:|||.::|.....:.:::::|..:.|
 Frog  1520 PSKQPTAESEALEL-RQLRSVQHSLLKILGKTLATLRAFTPDLCQILQVQPLDLAQYNLLFALSF 1583

  Fly  1564 GAPKLNEENLTLTFGIVLNLVNIYVKALNMQNHGFSEVPLNSLPNVEHSGDNDDPEVCVGNQTNR 1628
            ..|.. :.::|.:||.:|..||:.:..|.                 |.....|.|...|..:||.
 Frog  1584 TTPAF-DADVTPSFGTLLATVNVTLSMLG-----------------EMDKKKDHPLGQVLGETNS 1630

  Fly  1629 TFSKPLSNVSISTGTCPASELLSNMDGQLCLLALEHLLMLVASQAICIIRSPNLETLWKQIVRRD 1693
            |    :.|.:|.:               |.|..:|:...|:.|||:..:|.|::....||.::::
 Frog  1631 T----VDNKNIKS---------------LLLFIMENCFYLLISQAVRYLRDPSVHPRDKQRMKQE 1676

  Fly  1694 ISNEL 1698
            :|:||
 Frog  1677 LSSEL 1681

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nup188NP_001246283.1 Nup188 31..943 CDD:421740 242/953 (25%)
nup188NP_001107292.1 Nup188 30..935 CDD:371085 243/959 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1247..1267 4/19 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1504..1528 2/23 (9%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1696..1717
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 236 1.000 Domainoid score I2293
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 309 1.000 Inparanoid score I2565
OMA 1 1.010 - - QHG52707
OrthoDB 1 1.010 - - D201834at33208
OrthoFinder 1 1.000 - - FOG0006520
OrthoInspector 1 1.000 - - otm48553
Panther 1 1.100 - - LDO PTHR31431
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4870
SonicParanoid 1 1.000 - - X5492
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1111.110

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