DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GLS and gls2b

DIOPT Version :9

Sequence 1:	NP_001163129.1	Gene:	GLS / 36396	FlyBaseID:	FBgn0261625	Length:	775	Species:	Drosophila melanogaster
Sequence 2:	XP_005174017.1	Gene:	gls2b / 556445	ZFINID:	ZDB-GENE-050208-408	Length:	605	Species:	Danio rerio

Alignment Length:	611	Identity:	292/611 - (47%)
Similarity:	406/611 - (66%)	Gaps:	31/611 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 GHTGKQLQQKIINEKNLRAPPLMNLVFANRKLSFYDTSST--PKTKEDNAKLHREQEQRNAEDVL 114
            |...|...:..:...|:...||......|....|.:.:|.  ||:|   |.:..:......||:|
Zfish    16 GLLSKDAVKSSVRSPNVVRGPLSLFSRVNVISKFTEAASADQPKSK---ANMTNKDLFSGLEDML 77

  Fly   115 FDMFASEETGLISMGKFLAGLKTTGIRRNDPRVRELMDNLKKVHKLNNYETGSSAETQHLNRETF 179
            | ...:|....:.:..|.|.||:||:..:|||:|:.|:.:::..:      .|:.|.. ::||.|
Zfish    78 F-YTITEGAEKVPVSHFTAALKSTGLLTSDPRLRDCMEKIRRAVR------DSTGEVM-MDRELF 134

  Fly   180 KAVVAPNIVLIAKAFRQQFVIPDFTSFVKDIEDIYNRCKTNTLGKLADYIPQLARYNPDSWGLSI 244
            |...:.||||::.|||::|:||:|.:||..|..||...|....|::|.|||.|.:::||.||:|:
Zfish   135 KKCASGNIVLLSLAFRRKFIIPEFEAFVDIINHIYYTSKLQQDGQVAKYIPHLTKFSPDLWGVSL 199

  Fly   245 CTIDGQRFSIGDVDVPFTLQSCSKPLTYAIALEKLGPKVVHSYVGQEPSGRNFNELVLDQNKKPH 309
            ||:||||.|:||..|||.||||.|||.||||:.:.|.:.||.|||:||||..||:|.||:..|||
Zfish   200 CTVDGQRHSVGDTKVPFCLQSCVKPLEYAIAVHEHGTEHVHQYVGKEPSGFKFNKLSLDEEDKPH 264

  Fly   310 NPMINAGAILTCSLMNALVKPDMTSAEIFDYTMSWFKRLSGGEYIGFNNAVFLSEREAADRNYAL 374
            |||:|||||:..||:..:.|     ||.|||.|.:.|:::|.||:||:||.|.||:|..|||||:
Zfish   265 NPMVNAGAIVISSLIKGVNK-----AEKFDYVMDFVKKMTGSEYVGFSNATFQSEKETGDRNYAI 324

  Fly   375 GFYMRENKCFPKRTNLKEVMDFYFQCCSMETNCEAMSVIAASLANGGICPTTEEKVFRPEVIRDV 439
            |:|::|.||||....:.:.:|||||.|::|..||:.||:||:||||||||.|.|:|...|.:|:.
Zfish   325 GYYLKEKKCFPDGVEMIDALDFYFQLCAIEVTCESGSVMAATLANGGICPITGERVLSTEAVRNT 389

  Fly   440 LSIMHSCGTYDYSGQFAFKVGLPAKSGVSGGMMLVIPNVMGIFAWSPPLDHLGNTVRGLQFCEEL 504
            ||:|||||.|||||||||.|||||||||||.::||:|||||:..||||:|.:||:|||::||:||
Zfish   390 LSLMHSCGMYDYSGQFAFHVGLPAKSGVSGAVLLVVPNVMGVMCWSPPVDKVGNSVRGIRFCQEL 454

  Fly   505 VSMFNFHRYDNLKHLSNKKDPRKHRYETKGLSIVNLLFSAASGDVTALRRHRLSGMDITLADYDG 569
            ||:||||.||||:|...|:|||:...:.:..|:|||:|:|.||||:||||..||.|::.|.|||.
Zfish   455 VSLFNFHNYDNLRHFLKKQDPRRQSGDDRNKSVVNLMFAAHSGDVSALRRFALSSMNMELRDYDS 519

  Fly   570 RTALHLAASEGHLECVKFLLEQCHVPHNP--KDRWGNLPVDEAENFGHCHVVEFLRSWAEKADQS 632
            ||.||:||:|||::.|.||::.|.|  ||  ||||||:|.|:|..||...||:.|       ::.
Zfish   520 RTPLHVAAAEGHVDVVLFLIQACKV--NPFVKDRWGNIPRDDAMQFGQKDVVKIL-------EEY 575

  Fly   633 SEECKPEAVTSKTQADEVSSSSNSSS 658
            .:...|:  ||:|..:::|..|..||
Zfish   576 EQTYSPQ--TSQTDTEDLSQPSKCSS 599

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GLS	NP_001163129.1	Glutaminase	223..513	CDD:282773	173/289 (60%)
		Ank_4	538..589	CDD:290365	31/50 (62%)
		ANK	540..>622	CDD:238125	47/83 (57%)
		ANK repeat	540..566	CDD:293786	15/25 (60%)
		ANK repeat	568..600	CDD:293786	17/33 (52%)
		Ank_4	569..622	CDD:290365	29/54 (54%)
gls2b	XP_005174017.1	Glutaminase	178..463	CDD:282773	173/289 (60%)
		ANK	<490..572	CDD:238125	47/83 (57%)
		Ank_4	490..539	CDD:290365	29/48 (60%)
		ANK repeat	490..516	CDD:293786	15/25 (60%)
		ANK repeat	518..550	CDD:293786	17/33 (52%)
		Ank_4	520..572	CDD:290365	29/53 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595539
Domainoid	1	1.000	397	1.000	Domainoid score	I717
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	587	1.000	Inparanoid score	I954
OMA	1	1.010	-	-		QHG52573
OrthoDB	1	1.010	-	-		D175372at33208
OrthoFinder	1	1.000	-	-		FOG0001327
OrthoInspector	1	1.000	-	-		otm24897
orthoMCL	1	0.900	-	-		OOG6_102294
Panther	1	1.100	-	-	O	PTHR12544
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X936
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.910