DRSC/TRiP Functional Genomics Resources

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Protein Alignment GLS and GLS2

DIOPT Version :9

Sequence 1:NP_001163129.1 Gene:GLS / 36396 FlyBaseID:FBgn0261625 Length:775 Species:Drosophila melanogaster
Sequence 2:NP_037399.2 Gene:GLS2 / 27165 HGNCID:29570 Length:602 Species:Homo sapiens


Alignment Length:578 Identity:280/578 - (48%)
Similarity:378/578 - (65%) Gaps:50/578 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly   102 HREQEQRNAEDVLFDMFASEETGLIS------------------MGKFLAGLKTTGIRRNDPRVR 148
            |..|.|....|       |.|:|::|                  :.||...||.||::.:|||:|
Human    52 HSHQPQHQDHD-------SSESGMLSRLGDLLFYTIAEGQERIPIHKFTTALKATGLQTSDPRLR 109

  Fly   149 ELMDNLKKVHKLNNYETGSSAETQHLNRETFKAVVAPNIVLIAKAFRQQFVIPDFTSFVKDIEDI 213
            :.|..:.:|       ...|:....|:|:.|:..|:.||||:.:|||::||||||..|...::.|
Human   110 DCMSEMHRV-------VQESSSGGLLDRDLFRKCVSSNIVLLTQAFRKKFVIPDFEEFTGHVDRI 167

  Fly   214 YNRCKTNTLGKLADYIPQLARYNPDSWGLSICTIDGQRFSIGDVDVPFTLQSCSKPLTYAIALEK 278
            :...|..|.||:|.||||||:.|||.||:|:||:||||.|:|...:||.||||.|||||||::..
Human   168 FEDVKELTGGKVAAYIPQLAKSNPDLWGVSLCTVDGQRHSVGHTKIPFCLQSCVKPLTYAISIST 232

  Fly   279 LGPKVVHSYVGQEPSGRNFNELVLDQNKKPHNPMINAGAILTCSLMNALVKPDMTSAEIFDYTMS 343
            ||...||.:||:||||..:|:|.|::...|||||:|||||    ::::|:|.|...||.||:.:.
Human   233 LGTDYVHKFVGKEPSGLRYNKLSLNEEGIPHNPMVNAGAI----VVSSLIKMDCNKAEKFDFVLQ 293

  Fly   344 WFKRLSGGEYIGFNNAVFLSEREAADRNYALGFYMRENKCFPKRTNLKEVMDFYFQCCSMETNCE 408
            :..:::|.||:||:||.|.||:|..|||||:|:|::|.|||||..::...:|.|||.||:|..||
Human   294 YLNKMAGNEYMGFSNATFQSEKETGDRNYAIGYYLKEKKCFPKGVDMMAALDLYFQLCSVEVTCE 358

  Fly   409 AMSVIAASLANGGICPTTEEKVFRPEVIRDVLSIMHSCGTYDYSGQFAFKVGLPAKSGVSGGMML 473
            :.||:||:||||||||.|.|.|...|.:|:.||:|||||.||:||||||.|||||||.|||.::|
Human   359 SGSVMAATLANGGICPITGESVLSAEAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKSAVSGAILL 423

  Fly   474 VIPNVMGIFAWSPPLDHLGNTVRGLQFCEELVSMFNFHRYDNLKHLSNKKDPRKHRYETKGLSIV 538
            |:|||||:...|||||.|||:.||..||::|||:||||.||||:|.:.|.|||:...|.:..::|
Human   424 VVPNVMGMMCLSPPLDKLGNSHRGTSFCQKLVSLFNFHNYDNLRHCARKLDPRREGAEIRNKTVV 488

  Fly   539 NLLFSAASGDVTALRRHRLSGMDITLADYDGRTALHLAASEGHLECVKFLLEQCHVPHNPKDRWG 603
            ||||:|.||||:||||..||.||:...|||.|||||:||:|||:|.||||:|.|.|....|||||
Human   489 NLLFAAYSGDVSALRRFALSAMDMEQKDYDSRTALHVAAAEGHIEVVKFLIEACKVNPFAKDRWG 553

  Fly   604 NLPVDEAENFGHCHVVEFLRSWAEKADQSSEECKPEAVTSKTQAD---EVSSSSNSSS 658
            |:|:|:|..|.|..||:.|:.:.:           ....|:|||:   |..|..|..|
Human   554 NIPLDDAVQFNHLEVVKLLQDYQD-----------SYTLSETQAEAAAEALSKENLES 600

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GLSNP_001163129.1 Glutaminase 223..513 CDD:282773 167/289 (58%)
Ank_4 538..589 CDD:290365 35/50 (70%)
ANK 540..>622 CDD:238125 50/81 (62%)
ANK repeat 540..566 CDD:293786 16/25 (64%)
ANK repeat 568..600 CDD:293786 19/31 (61%)
Ank_4 569..622 CDD:290365 31/52 (60%)
GLS2NP_037399.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..67 6/21 (29%)
Glutaminase 177..463 CDD:282773 167/289 (58%)
ANK 490..>575 CDD:238125 51/84 (61%)
Ank_4 490..539 CDD:290365 33/48 (69%)
ANK repeat 490..516 CDD:293786 16/25 (64%)
ANK repeat 518..550 CDD:293786 19/31 (61%)
ANK 1. /evidence=ECO:0000255 518..547 19/28 (68%)
Ank_4 520..572 CDD:290365 31/51 (61%)
ANK 2. /evidence=ECO:0000255 552..581 11/39 (28%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 397 1.000 Domainoid score I749
eggNOG 1 0.900 - - E1_COG2066
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 592 1.000 Inparanoid score I984
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG52573
OrthoDB 1 1.010 - - D175372at33208
OrthoFinder 1 1.000 - - FOG0001327
OrthoInspector 1 1.000 - - otm40899
orthoMCL 1 0.900 - - OOG6_102294
Panther 1 1.100 - - LDO PTHR12544
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2545
SonicParanoid 1 1.000 - - X936
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1413.870

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