Protein Alignment GLS and glna-1

DIOPT Version :10

• Sequence 1: NP_001163129.1
• Gene: GLS / 36396
• FlyBaseID: FBgn0261625
• Length: 775
• Species: Drosophila melanogaster
• Sequence 2: NP_001293582.1
• Gene: glna-1 / 175130
• WormBaseID: WBGene00007480
• Length: 856
• Species: Caenorhabditis elegans
• Alignment Length: 617
• Identity: 267/617 - (43%)
• Similarity: 373/617 - (60%)
• Gaps: 57/617 - (9%)

  Fly    91 TPKTKEDNAK------------------------LHREQEQRNAEDVLFDMFASEETGL-ISMGK 130
            |||..|.|.:                        |.|.::...|.|::..:|....... .|..:
 Worm    81 TPKIDEKNLEYIGEVLERKKSVVPFLTQTINQLALVRNEKMERAADLICTLFRLPHGSTDCSFFR 145

  Fly   131 FLAGLKTTGIRRNDPRVRELMDNLKKVHKLNNYETGSSAETQHLNRETFKAVVAPNIVLIAKAFR 195
            .:..|::.||..||||::::.|.:|| |...|.::...|    :::|.||.::.|..:||::..|
 Worm   146 LIKVLRSFGIWENDPRLKQMFDRMKK-HDEENEDSRQWA----MSQEKFKEIIFPCTILISRTLR 205

  Fly   196 QQFVIPDFTSFVKDIEDIYNRCKTNTLGKLADYIPQLARYNPDSWGLSICTIDGQRFSIGDVDVP 260
            .|.:||.:..|.:.||.|:..|:.:..|::|.|||||||.:|..||:|||||||||||:||....
 Worm   206 NQLIIPSWLEFTQLIETIFETCRESKEGEVASYIPQLARQSPHLWGMSICTIDGQRFSLGDSKKN 270

  Fly   261 FTLQSCSKPLTYAIALEKLGPKVVHSYVGQEPSGRNFNELVLDQNKKPHNPMINAGAILTCSLMN 325
            |.|||.||...|||...::|..|:|.|||.|||||.|||:.||.|..||||:||||||:..|
 Worm   271 FCLQSVSKAFNYAIVASEIGSHVLHQYVGHEPSGRLFNEICLDSNNMPHNPLINAGAIVVTS--- 332

  Fly   326 ALVKPDMTSAEIFDYTMSWFKRLSGGEYIGFNNAVFLSEREAADRNYALGFYMRENKCFP----- 385
             ::||..:.|:.||:.:..:::|:||.::||:||.|||||:.|||||||.:||:|.:|||
 Worm   333 -MIKPTHSMADRFDFMLKQYRKLAGGGHVGFDNATFLSERDTADRNYALSYYMKEYRCFPDESQV 396

  Fly   386 --KRTNLKEVMDFYFQCCSMETNCEAMSVIAASLANGGICPTTEEKVFRPEVIRDVLSIMHSCGT 448
              |...|:|.:|.|||.||:||||:..:|:||:||||||||.|.||.......||:||:|:|||.
 Worm   397 YEKAKGLREELDLYFQLCSLETNCDTAAVMAATLANGGICPLTTEKCLGSRPCRDILSLMYSCGM 461

  Fly   449 YDYSGQFAFKVGLPAKSGVSGGMMLVIPNVMGIFAWSPPLDHLGNTVRGLQFCEELVSMFNFHRY 513
            |||||:|||:|||||||||||.|::||||||||..:|||||..||:.||:.||.:|:..||||.|
 Worm   462 YDYSGKFAFQVGLPAKSGVSGIMIVVIPNVMGIALYSPPLDKTGNSCRGVAFCRQLIDKFNFHNY 526

  Fly   514 DNLKHL--SNKKDPRKHRYETKGLSIVNLLFSAASGDVTALRRHRLSGMDITLADYDGRTALHLA 576
            |:|.|.  |.|.|||:.....:..:||.::::|.:||:.:|||..:.|.|:..||||.|||||:|
 Worm   527 DSLLHPDDSRKIDPRRKIGPRENETIVQVMYAAKNGDLDSLRRMFMQGADLKTADYDNRTALHVA 591

  Fly   577 ASEGHLECVKFLLEQCHVPHNPKDRWGNLPVDEAENFGHCHVVEFL-----------RSWAE-KA 629
            |:||.::..|||:....:||:.:||||..|:|:|..|.:..|..:|           .:|.| ..
 Worm   592 AAEGRIKVCKFLINIVGIPHDVRDRWGRYPLDDARQFKNKEVALYLFRLQYPTKRMPENWFEVGG 656

  Fly   630 DQSSEECKPEAVTSKTQADEVSSSSNSSSSPG 661
            |....|.:|:  .|.....|..||.......|
 Worm   657 DLLVSELEPD--NSSVDDGEAESSGEDELGNG 686

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GLS	NP_001163129.1	EF-hand_14	110..201	CDD:465587	25/91 (27%)
		Glutaminase	223..511	CDD:461499	169/294 (57%)
		Ank_2	540..622	CDD:463710	35/81 (43%)
		ANK repeat	540..566	CDD:293786	8/25 (32%)
		ANK repeat	568..600	CDD:293786	15/31 (48%)
glna-1	NP_001293582.1	EF-hand_14	124..211	CDD:465587	25/91 (27%)
		Glutaminase	233..524	CDD:461499	169/294 (57%)
		ANKYR	<556..637	CDD:440430	35/80 (44%)
		ANK repeat	583..615	CDD:293786	15/31 (48%)