DRSC/TRiP Functional Genomics Resources

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Protein Alignment GLS and Gls

DIOPT Version :9

Sequence 1:NP_001163129.1 Gene:GLS / 36396 FlyBaseID:FBgn0261625 Length:775 Species:Drosophila melanogaster
Sequence 2:NP_001074550.1 Gene:Gls / 14660 MGIID:95752 Length:674 Species:Mus musculus


Alignment Length:515 Identity:282/515 - (54%)
Similarity:382/515 - (74%) Gaps:12/515 - (2%)


- Green bases have known domain annotations that are detailed below.


  Fly   111 EDVLFDMFASEETGLISMGKFLAGLKTTGIRRNDPRVRELMDNLKKVHKLNNYETGSSAETQHLN 175
            ||:||...| |....|.:.||:..||:||:|.:|||::|.||.|:...:       ::::...|:
Mouse   145 EDLLFYTIA-EGQEKIPVHKFITALKSTGLRTSDPRLKECMDMLRLTLQ-------TTSDGVMLD 201

  Fly   176 RETFKAVVAPNIVLIAKAFRQQFVIPDFTSFVKDIEDIYNRCKTNTLGKLADYIPQLARYNPDSW 240
            ::.||..|..||||:.:|||::||||||.||...|:::|...|..:.||:||||||||:::||.|
Mouse   202 KDLFKKCVQSNIVLLTQAFRRKFVIPDFMSFTSHIDELYESAKKQSGGKVADYIPQLAKFSPDLW 266

  Fly   241 GLSICTIDGQRFSIGDVDVPFTLQSCSKPLTYAIALEKLGPKVVHSYVGQEPSGRNFNELVLDQN 305
            |:|:||:||||.||||..|||.||||.|||.||||:..||.:.||.|||:||||..||:|.|:::
Mouse   267 GVSVCTVDGQRHSIGDTKVPFCLQSCVKPLKYAIAVNDLGTEYVHRYVGKEPSGLRFNKLFLNED 331

  Fly   306 KKPHNPMINAGAILTCSLMNALVKPDMTSAEIFDYTMSWFKRLSGGEYIGFNNAVFLSEREAADR 370
            .||||||:|||||:..|    |:|..:.:||.|||.|.:..:::|.||:||:||.|.||||:.||
Mouse   332 DKPHNPMVNAGAIVVTS----LIKQGVNNAEKFDYVMQFLNKMAGNEYVGFSNATFQSERESGDR 392

  Fly   371 NYALGFYMRENKCFPKRTNLKEVMDFYFQCCSMETNCEAMSVIAASLANGGICPTTEEKVFRPEV 435
            |:|:|:|::|.||||:.|::..::|||||.||:|..||:.||:||:|||||.||.|.|:|..||.
Mouse   393 NFAIGYYLKEKKCFPEGTDMVGILDFYFQLCSIEVTCESASVMAATLANGGFCPITGERVLSPEA 457

  Fly   436 IRDVLSIMHSCGTYDYSGQFAFKVGLPAKSGVSGGMMLVIPNVMGIFAWSPPLDHLGNTVRGLQF 500
            :|:.||:|||||.||:||||||.|||||||||:||::||:|||||:..||||||.:||:|:|:.|
Mouse   458 VRNTLSLMHSCGMYDFSGQFAFHVGLPAKSGVAGGILLVVPNVMGMMCWSPPLDKMGNSVKGIHF 522

  Fly   501 CEELVSMFNFHRYDNLKHLSNKKDPRKHRYETKGLSIVNLLFSAASGDVTALRRHRLSGMDITLA 565
            |.:|||:.|||.||||:|.:.|.|||:...:.:..|::||||:|.:|||:||||..||.||:...
Mouse   523 CHDLVSLCNFHNYDNLRHFAKKLDPRREGGDQRVKSVINLLFAAYTGDVSALRRFALSAMDMEQR 587

  Fly   566 DYDGRTALHLAASEGHLECVKFLLEQCHVPHNPKDRWGNLPVDEAENFGHCHVVEFLRSW 625
            |||.|||||:||:|||:|.||||||.|.|...|||||.|.|:|||.:|||..|.:.|:.:
Mouse   588 DYDSRTALHVAAAEGHVEVVKFLLEACKVNPFPKDRWNNTPMDEALHFGHHDVFKILQEY 647

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GLSNP_001163129.1 Glutaminase 223..513 CDD:282773 176/289 (61%)
Ank_4 538..589 CDD:290365 33/50 (66%)
ANK 540..>622 CDD:238125 51/81 (63%)
ANK repeat 540..566 CDD:293786 15/25 (60%)
ANK repeat 568..600 CDD:293786 21/31 (68%)
Ank_4 569..622 CDD:290365 33/52 (63%)
GlsNP_001074550.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 56..123
EF-hand_14 144..227 CDD:375448 34/89 (38%)
Glutaminase 249..535 CDD:377427 176/289 (61%)
Highly mobile activation loop. /evidence=ECO:0000269|PubMed:27542409 320..327 3/6 (50%)
Ank_2 562..652 CDD:372319 52/86 (60%)
ANK repeat 562..588 CDD:293786 15/25 (60%)
ANK repeat 590..622 CDD:293786 21/31 (68%)
ANK 1 590..619 20/28 (71%)
ANK 2 624..653 11/24 (46%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 652..674
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167849750
Domainoid 1 1.000 399 1.000 Domainoid score I742
eggNOG 1 0.900 - - E1_COG2066
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H22726
Inparanoid 1 1.050 594 1.000 Inparanoid score I964
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG52573
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001327
OrthoInspector 1 1.000 - - otm42972
orthoMCL 1 0.900 - - OOG6_102294
Panther 1 1.100 - - O PTHR12544
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2545
SonicParanoid 1 1.000 - - X936
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1615.790

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