Protein Alignment GLS and GLS

DIOPT Version :10

• Sequence 1: NP_001163129.1
• Gene: GLS / 36396
• FlyBaseID: FBgn0261625
• Length: 775
• Species: Drosophila melanogaster
• Sequence 2: XP_061501193.1
• Gene: GLS / 1275039
• VectorBaseID: AGAMI1_007795
• Length: 652
• Species: Anopheles gambiae
• Alignment Length: 585
• Identity: 407/585 - (69%)
• Similarity: 479/585 - (81%)
• Gaps: 4/585 - (0%)

  Fly    80 NRKLSFYDTSSTPKTKEDNAKLHREQEQRNAEDVLFDMFASEETGLISMGKFLAGLKTTGIRRND 144
            ::|..||:...  |.....|...|:.:::::||.||:||.::||..::||||||.|:|.||||.|
Mosquito    69 SQKAHFYNVDR--KRPPPQADEQRDTDKKHSEDQLFNMFKNKETNTVNMGKFLAELRTIGIRRTD 131

  Fly   145 PRVRELMDNLKKVHKLNNYETGSSAETQHLNRETFKAVVAPNIVLIAKAFRQQFVIPDFTSFVKD 209
            ||::|||||||:||||||||.| |..|||||.||||||:||||||||:|||.|||||||..|.||
Mosquito   132 PRIQELMDNLKRVHKLNNYEHG-SPHTQHLNEETFKAVIAPNIVLIARAFRHQFVIPDFQGFTKD 195

  Fly   210 IEDIYNRCKTNTLGKLADYIPQLARYNPDSWGLSICTIDGQRFSIGDVDVPFTLQSCSKPLTYAI 274
            ||:||.:||:|..||:|:|||||:|.|||.||:|:||||||||||||..||||||||||||||||
Mosquito   196 IEEIYWKCKSNADGKVANYIPQLSRVNPDYWGVSVCTIDGQRFSIGDTSVPFTLQSCSKPLTYAI 260

  Fly   275 ALEKLGPKVVHSYVGQEPSGRNFNELVLDQNKKPHNPMINAGAILTCSLMNALVKPDMTSAEIFD 339
            ||||||.:|||.|:|||||||||||||||..||||||||||||||||||:..||.|:||.||.||
Mosquito   261 ALEKLGAQVVHQYIGQEPSGRNFNELVLDYEKKPHNPMINAGAILTCSLLKTLVHPEMTLAEKFD 325

  Fly   340 YTMSWFKRLSGGEYIGFNNAVFLSEREAADRNYALGFYMRENKCFPKRTNLKEVMDFYFQCCSME 404
            |..:||.|::|.|.:||||||||||||||||||||||||||:||:|::.||:|.||||||.||||
Mosquito   326 YAQTWFSRMAGNEPLGFNNAVFLSEREAADRNYALGFYMREHKCYPEKANLRECMDFYFQICSME 390

  Fly   405 TNCEAMSVIAASLANGGICPTTEEKVFRPEVIRDVLSIMHSCGTYDYSGQFAFKVGLPAKSGVSG 469
            ..|:.:||:||:||||||||.|||:|.:.|.:|||||:|||||.||:||||||||||||||||.|
Mosquito   391 ATCDTLSVVAATLANGGICPLTEERVLQSENVRDVLSLMHSCGMYDFSGQFAFKVGLPAKSGVCG 455

  Fly   470 GMMLVIPNVMGIFAWSPPLDHLGNTVRGLQFCEELVSMFNFHRYDNLKHLSNKKDPRKHRYETKG 534
            |:|||||||||:|.||||||.|||:.||:|||:|||.:||||.|||:||.|||||||:|||||||
Mosquito   456 GVMLVIPNVMGMFMWSPPLDPLGNSCRGVQFCKELVDVFNFHLYDNIKHGSNKKDPRRHRYETKG 520

  Fly   535 LSIVNLLFSAASGDVTALRRHRLSGMDITLADYDGRTALHLAASEGHLECVKFLLEQCHVPHNPK 599
            ||:||||||||.|||||||||:||||||||:|||||||||||::|||.|||:||||.|.|||:||
Mosquito   521 LSVVNLLFSAAIGDVTALRRHKLSGMDITLSDYDGRTALHLASAEGHYECVRFLLEHCGVPHDPK 585

  Fly   600 DRWGNLPVDEAENFGHCHVVEFLRSWAEKADQSSEECKPEAVTSKTQADEVSSSSNSSSSPGSSP 664
            |||||.|:||||.|.|..||..||.|.||. |.::.|:.......:..|..:||...:..|..||
Mosquito   586 DRWGNRPIDEAETFAHEDVVTLLRQWEEKV-QKAQTCEASETGYNSDQDSDASSGKGTKGPAGSP 649

  Fly   665  664
            Mosquito   650  649

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GLS	NP_001163129.1	EF-hand_14	110..201	CDD:465587	65/90 (72%)
		Glutaminase	223..511	CDD:461499	220/287 (77%)
		Ank_2	540..622	CDD:463710	64/81 (79%)
		ANK repeat	540..566	CDD:293786	23/25 (92%)
		ANK repeat	568..600	CDD:293786	24/31 (77%)
GLS	XP_061501193.1	None