Protein Alignment CG8646 and ARSJ

DIOPT Version :10

• Sequence 1: NP_610807.3
• Gene: CG8646 / 36394
• FlyBaseID: FBgn0033763
• Length: 562
• Species: Drosophila melanogaster
• Sequence 2: NP_078866.3
• Gene: ARSJ / 79642
• HGNCID: 26286
• Length: 599
• Species: Homo sapiens
• Alignment Length: 565
• Identity: 217/565 - (38%)
• Similarity: 297/565 - (52%)
• Gaps: 78/565 - (13%)

  Fly     5 WLICLL----LPIIDAAEVEK-----------------SPAKPNIIFILADDLGFNDVGFHGSAE 48
            |::|||    |....|.|.|:                 |.::|::|||||||.||.|||:||| |
Human    34 WILCLLTYGYLSWGQALEEEEEGALLAQAGEKLEPSTTSTSQPHLIFILADDQGFRDVGYHGS-E 97

  Fly    49 IPTPNIDALAYSGIILNRYYVAPICTPSRSALMTGKYPIHTGMQHTVLYAAEPRGLPLEEKILPQ 113
            |.||.:|.||..|:.|..|||.||||||||..:||||.||||:||:::...:|..|||:...|||
Human    98 IKTPTLDKLAAEGVKLENYYVQPICTPSRSQFITGKYQIHTGLQHSIIRPTQPNCLPLDNATLPQ 162

  Fly   114 YLNELGYTSHIAGKWHLGHWKLKYTPLYRGFSSHVGFWSGHQDYNDHTAVEN-NQWGLDMRNGTQ 177
            .|.|:||::|:.||||||.::.:..|..|||.:..|...|..||..|...:: ...|.|:.....
Human   163 KLKEVGYSTHMVGKWHLGFYRKECMPTRRGFDTFFGSLLGSGDYYTHYKCDSPGMCGYDLYENDN 227

  Fly   178 VAYDL-HGHYTTDVITDHSVKVIANHNATKGPLFLYVAHAACHSSNPYNPLPVPDNDVIKMSHIP 241
            .|:|. :|.|:|.:.|....:::|:||.|| |:|||:|:.|.||     ||..|.........|.
Human   228 AAWDYDNGIYSTQMYTQRVQQILASHNPTK-PIFLYIAYQAVHS-----PLQAPGRYFEHYRSII 286

  Fly   242 NYKRRKFAAMVSKMDNSVGQIVDQLRKSNMLENSIIIFSSDNGG-PAQGFNLNFASNYPLKGVKN 305
            |..||::|||:|.:|.::..:...|:......|||||:|||||| |..|     .||:||:|.|.
Human   287 NINRRRYAAMLSCLDEAINNVTLALKTYGFYNNSIIIYSSDNGGQPTAG-----GSNWPLRGSKG 346

  Fly   306 TLWEGGVRAAGLMWSPLLKKSQRVSNQTMHIIDWLPTLLEAAGGQPALSNLSKQIDGQSIWRALV 370
            |.||||:||.|.:.|||||....|..:.:||.||.|||:..|.||   .:...|:||..||..:.
Human   347 TYWEGGIRAVGFVHSPLLKNKGTVCKELVHITDWYPTLISLAEGQ---IDEDIQLDGYDIWETIS 408

  Fly   371 QDKASPRLNVLHNIDDIWGSAALSVGDWKLVKGTNYRGSWDGWYG---PAGERDPRLYDWQLV-- 430
            :...|||:::|||||.|:..|.              .|||...||   .|.:...|:..|:|:
Human   409 EGLRSPRVDILHNIDPIYTKAK--------------NGSWAAGYGIWNTAIQSAIRVQHWKLLTG 459

  Fly   431 --GRSRAGKALEALKMLPSRADQQRIRAAATVSCPGQSSQGTSCVATAFSAPCLFHIRDDPCEQY 493
              |.|..........:.|:|...:||..          |.|.|.        .||:|..||.|:.
Human   460 NPGYSDWVPPQSFSNLGPNRWHNERITL----------STGKSV--------WLFNITADPYERV 506

  Fly   494 NLAKQYPEVVNALMTELERFNATAVPPSNKPADPRADPRFWNYTW 538
            :|:.:||.:|..|:..|.:||.||||....|.|||::||.....|
Human   507 DLSNRYPGIVKKLLRRLSQFNKTAVPVRYPPKDPRSNPRLNGGVW 551

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8646	NP_610807.3	4-S	26..405	CDD:293753	165/381 (43%)
		DUF4976	<480..510	CDD:419068	11/29 (38%)
ARSJ	NP_078866.3	4-S	76..509	CDD:293753	189/479 (39%)
		DUF4976	<495..>533	CDD:419068	17/37 (46%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	531..599		9/21 (43%)