DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8646 and arsg

DIOPT Version :9

Sequence 1:	NP_610807.3	Gene:	CG8646 / 36394	FlyBaseID:	FBgn0033763	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_001352290.1	Gene:	arsg / 564790	ZFINID:	ZDB-GENE-060503-154	Length:	526	Species:	Danio rerio

Alignment Length:	575	Identity:	140/575 - (24%)
Similarity:	229/575 - (39%)	Gaps:	159/575 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 KPNIIFILADDLGFNDVGFH-GSAEIPTPNIDALAYSGIILNRYY-VAPICTPSRSALMTGKYPI 87
            :||.|.|||||:|:.|:..: .....|||.:|:|...|.....:: .|..|:|||::::||::.:
Zfish    34 RPNFIIILADDIGWGDLWLNRPDNSTPTPWLDSLMLKGKRFTDFHSPASTCSPSRASILTGRHGL 98

  Fly    88 HTGMQHTVLYAAEPRGLPLEEKILPQYLNELGYTSHIAGKWHLGHWKLKYTPLYRGFSSHVGF-W 151
            ..|:.|. .......||||.|....|.|::.||.:.:.||||||| ...|:|::|||..::|. :
Zfish    99 RNGVTHN-FAVGSVGGLPLNETTFAQLLHDEGYYTAMIGKWHLGH-NGSYSPVHRGFDYYLGIPY 161

  Fly   152 SGHQDYNDHTAVE--------NNQWGLDMRNG---TQV----------------AYDLHGHYTTD 189
            |......|...::        ::|:.::.::.   |:|                .:.|...|.|
Zfish   162 SNDMGCTDKPGLDLPSCPPCVHSQYSINKKHEGCYTKVGLPLFENEKIIEQPLDTWSLKDRYAT- 225

  Fly   190 VITDHSVKVIANHNAT-KGPLFLYVAHAACHSSNPYNPLPVPDNDVIKMSHIPNYKRRKFAAMVS 253
                .:|:.|...:.| |.|..||||.|..|       :|:..|..:.::     ....:.|.:|
Zfish   226 ----AAVQQIFTASVTKKQPFLLYVALAHMH-------VPLFHNTFLNVT-----TEDPYTASLS 274

  Fly   254 KMDNSVGQIVDQLRKSNMLENSIIIFSSDNG------------GPAQGFNLNFASNYPLKGVKNT 306
            .||:.||.||..| .:..|||::|.|:.|||            ||..|   .:.:|......|.|
Zfish   275 DMDSLVGNIVQAL-ITEQLENTLIWFTGDNGPWEQKCLFAGHVGPFVG---RWQTNKGGGSAKRT 335

  Fly   307 LWEGGVRAAGLMWSPLLKKSQRVSNQTMHIIDWLPTLLEAAGGQPALSNLSKQIDGQSIWRALVQ 371
            .||||.|...::..|...|....|:..:..:|..||:|..||.:|.   ..::.||..|...|:.
Zfish   336 TWEGGHRVPTVVSWPKKIKHNSSSDALLSGLDIFPTVLSLAGVKPP---SDRRYDGIDITDVLLN 397

  Fly   372 DKASPRLNVLH-NIDDIWGSAALSVGDWKLVKGTNYRGSW--------DGWYGPAGERDPRLYDW 427
            |..:...:::| |     ..||...||.:.|:..:::..:        ||..||....||
Zfish   398 DSETGHESLMHPN-----SGAAGQYGDLQTVRLKHHKAFYITGGSVACDGESGPQQHHDP----- 452

  Fly   428 QLVGRSRAGKALEALKMLPSRADQQRIRAAATVSCPGQSSQGTSCVATAFSAPCLFHIRDDPCEQ 492
                                                                |.:|.:..|..|:
Zfish   453 ----------------------------------------------------PLIFDLSQDEAEE 465

  Fly   493 YNL---AKQYPEVVNALMTELE---------RFNA---TAVPPSNKPADPRADPR 532
            ..|   :|::..|:..:..|.|         |.:|   |.:|    .|:|..:|:
Zfish   466 TPLDPESKEFRSVLKQVEREREALLWDIATDRVSAADYTVIP----SAEPCCEPQ 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8646	NP_610807.3	AslA	25..459	CDD:225661	124/485 (26%)
		4-S	26..405	CDD:293753	118/422 (28%)
		DUF4976	<462..531	CDD:303608	15/83 (18%)
arsg	NP_001352290.1	ALP_like	34..469	CDD:329031	128/522 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910