DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8646 and sgsh

DIOPT Version :9

Sequence 1:	NP_610807.3	Gene:	CG8646 / 36394	FlyBaseID:	FBgn0033763	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_001116740.1	Gene:	sgsh / 563849	ZFINID:	ZDB-GENE-030131-4958	Length:	511	Species:	Danio rerio

Alignment Length:	567	Identity:	133/567 - (23%)
Similarity:	224/567 - (39%)	Gaps:	161/567 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 FLW-LICLLLPIIDAAEVEKSPAKPNIIFILADDLGFNDVGFHGSAEIPTPNIDALAYSGIIL-N 65
            |.| |:|||| ..|.......    |::.|:|||.|| :...:.:..:.||::.||:...:|. |
Zfish     5 FAWTLLCLLL-CFDVGGCRSR----NVLLIIADDGGF-ETDVYNNTVVQTPHLRALSKRSLIFKN 63

  Fly    66 RYYVAPICTPSRSALMT-------GKYPIHTGMQHTVLYAAEPRGLPLEEKILPQYLNELGYTSH 123
            .:.....|:||||.::|       |.|.:|.|:.|...:..        .:.||..|......:.
Zfish    64 AFTSVSSCSPSRSTILTGLPQHQNGMYGLHQGVHHFNSFDG--------VQSLPLLLKRANIHTG 120

  Fly   124 IAGKWHLGHWKLKYTPLYR-GFSSHVGFWSGHQDYNDHTAVENN--QWGLDMRNGTQVAYDLHGH 185
            |.||.|:|.     .|:|. .|:           |.:.|   |:  |.|   ||.|::...:...
Zfish   121 IIGKKHVGP-----GPVYPFDFA-----------YTEET---NSVLQVG---RNITKIKLLVRKF 163

  Fly   186 YTTDVITDHSVKVIANHNATKGPLFLYVA----HAACHSSNPYNPL------------PVPD--- 231
            :       .|.|...:....:.|.|||||    |...||...|...            .:||
Zfish   164 F-------QSHKEERSETKEERPFFLYVAFHDPHRCGHSQPQYGVFCEKFGNGESGMGRIPDWEP 221

  Fly   232 ----NDVIKMSH-IPN--YKRRKFAAM---VSKMDNSVGQIVDQLRKSNMLENSIIIFSSDNGGP 286
                .|.:|:.: ||:  ..|...||.   ||::|..:|.::::|||:....::::|:|||||
Zfish   222 KYYSPDQVKVPYFIPDTPAARADIAAQYTTVSRLDQGIGLVLEELRKAGFENDTLVIYSSDNG-- 284

  Fly   287 AQGFNLNFASNYPLKGVKNTLWEGGVRAAGLMWSPLLKKSQR---VSNQTMHIIDWLPTLLE--- 345
                       .|....:..|:..||:...|:.||  :..||   :|...:.::|..||:|:
Zfish   285 -----------IPFPNGRTNLYGSGVKEPMLLSSP--EHQQRWGKLSQAYVSLLDITPTILDWFS 336

  Fly   346 -------AAGGQPALSNLSKQIDGQSIWRALVQDKASPRL---NVLHNIDDIWGSAALSVGDWKL 400
                   .:..||.      ::.|:|:..||:.:.:...:   ..||.:...:...::..|.::|
Zfish   337 LPYPSYSLSMSQPV------ELTGRSLLPALISEPSWDTVFSSQSLHEVTMFYPMRSIHKGPYRL 395

  Fly   401 VKGTNYRGSW----DGWYGPAGERDPRLYDWQLVGRSRAGKALEALKMLPSRADQQRIRAAATVS 461
            :...:||..:    |.:..|..:        .|:.|:::|:.....|.|.....:||..
Zfish   396 LHNLHYRMPFPIDQDFYISPTFQ--------DLLNRTQSGRPTGWFKTLNEYYYRQRWE------ 446

  Fly   462 CPGQSSQGTSCVATAFSAPCLFHIRDDPCEQYNLA--KQYPEVVNAL 506
                                ||.:|.||.|:.|||  ..|.||:.:|
Zfish   447 --------------------LFDVRTDPMEKVNLAGDLDYSEVLESL 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8646	NP_610807.3	AslA	25..459	CDD:225661	112/493 (23%)
		4-S	26..405	CDD:293753	101/434 (23%)
		DUF4976	<462..531	CDD:303608	13/47 (28%)
sgsh	NP_001116740.1	SGSH	25..481	CDD:293751	125/542 (23%)
sgsh	NP_001116740.1	AslA	25..461	CDD:225661	119/528 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3119
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810