DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8646 and arsib

DIOPT Version :9

Sequence 1:	NP_610807.3	Gene:	CG8646 / 36394	FlyBaseID:	FBgn0033763	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	XP_692237.2	Gene:	arsib / 563783	ZFINID:	ZDB-GENE-100819-1	Length:	568	Species:	Danio rerio

Alignment Length:	600	Identity:	212/600 - (35%)
Similarity:	296/600 - (49%)	Gaps:	123/600 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MWFLWLICLLLPI----------IDAAEVEKSP--------AKPNIIFILADDLGFNDVGFHGSA 47
            |..|.|:.|.||.          .:...||:.|        ..|:|||||.||.||||:|:| |.
Zfish     1 MALLVLLILSLPACASMRTNREDFEGFRVEEKPEAAAFKPKQPPHIIFILTDDQGFNDIGYH-SG 64

  Fly    48 EIPTPNIDALAYSGIILNRYYVAPICTPSRSALMTGKYPIHTGMQHTVLYAAEPRGLPLEEKILP 112
            ||.:|.:|.||..|:.|..|||.|:||||||.|:||:|.||||:||:::...:|..|||:...||
Zfish    65 EIRSPTLDKLASEGVRLENYYVQPLCTPSRSQLITGRYQIHTGLQHSIIRPRQPNCLPLDVVTLP 129

  Fly   113 QYLNELGYTSHIAGKWHLGHWKLKYTPLYRGFSSHVGFWSGHQDYNDHTAVENNQ-WGLDMRNGT 176
            |.|.|:||::|:.||||||.::....|..|||.::.|..:|..||..:.:.:... .|.|:..|.
Zfish   130 QRLQEIGYSTHMVGKWHLGFYRKDCLPTRRGFHTYFGSLTGSVDYYTYGSCDGKSLCGFDLHEGE 194

  Fly   177 QVAYDLHGHYTTDVITDHSVKVIANHNATKGPLFLYVAHAACHSSNPYNPLPVPDNDVIKMSHIP 241
            .||:...|.|:|.:.|....|::|.|:.|..|||::::..|.|:     ||..|...:....:|.
Zfish   195 SVAWGRAGKYSTHLYTQRVRKILATHDPTSQPLFIFLSLQAVHT-----PLKPPKEYIYPYRNIG 254

  Fly   242 NYKRRKFAAMVSKMDNSVGQIVDQLRKSNMLENSIIIFSSDNGG-PAQGFNLNFASNYPLKGVKN 305
            |..|||:|||||.:|.:|..|...|||.....||::|||:|||. |..|     .||:||:|.|.
Zfish   255 NVPRRKYAAMVSIVDEAVRNITYALRKYGFYRNSVVIFSTDNGAQPLTG-----GSNWPLRGCKG 314

  Fly   306 TLWEGGVRAAGLMWSPLLKKSQRVSNQTMHIIDWLPTLLEAAGGQPALSNLSKQ--IDGQSIWRA 368
            |.||||:|..|.:.|||::..:|:|...:||.||.|||:..|||     |:|:.  :||..:|..
Zfish   315 TYWEGGIRGVGFVHSPLIRHRRRISRDLIHITDWYPTLVGLAGG-----NVSQHQGLDGFDVWPT 374

  Fly   369 LVQDKASPRLNVLHNID--------------DIWGS---AALSVGDWKLVKGTNYRGSW------ 410
            :.:.|.||||.:|||||              .:|.:   ||:.||||||:.|....|.|
Zfish   375 ISEGKESPRLEILHNIDPLNRRSRGSLKDGYGLWDTTVQAAIRVGDWKLLTGDPGNGDWVPPHVL 439

  Fly   411 ----DGWYGPAGERDPRLYDWQLVGRSRAGKALEALKMLPSRADQQRIRAAATVSCPGQSSQGTS 471
                ..|:..  |||        :|..|
Zfish   440 THFPSSWWHL--ERD--------IGEKR------------------------------------- 457

  Fly   472 CVATAFSAPCLFHIRDDPCEQYNLAKQYPEVVNALMTELERFNATAVPPSNKPADPRADPR---- 532
                  .:..||::..||||:::||...|:||..|:..|...|.||:|....|.|.||:|.
Zfish   458 ------KSVWLFNVTGDPCERHDLAVHRPDVVRELLARLAFHNRTAIPVRYPPDDTRANPSANGG 516

  Fly   533 FWNYTWTNFGDYQNN 547
            .|. .|....|.:.|
Zfish   517 AWR-PWVGEDDEEEN 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8646	NP_610807.3	AslA	25..459	CDD:225661	177/464 (38%)
		4-S	26..405	CDD:293753	169/399 (42%)
		DUF4976	<462..531	CDD:303608	21/68 (31%)
arsib	XP_692237.2	AslA	40..479	CDD:225661	185/507 (36%)
arsib	XP_692237.2	4-S	44..476	CDD:293753	183/500 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	294	0.414	Domainoid score	I1467
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	351	1.000	Inparanoid score	I2236
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D375140at33208
OrthoFinder	1	1.000	-	-		FOG0000852
OrthoInspector	1	1.000	-	-		mtm6503
orthoMCL	1	0.900	-	-		OOG6_100690
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1868
SonicParanoid	1	1.000	-	-		X499
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.900