DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8646 and SULF2

DIOPT Version :9

Sequence 1:	NP_610807.3	Gene:	CG8646 / 36394	FlyBaseID:	FBgn0033763	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_001373981.1	Gene:	SULF2 / 55959	HGNCID:	20392	Length:	871	Species:	Homo sapiens

Alignment Length:	519	Identity:	127/519 - (24%)
Similarity:	208/519 - (40%)	Gaps:	126/519 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 KPNIIFILADDLGFNDVGFHGSAEIPTPNIDALAYSGI-ILNRYYVAPICTPSRSALMTGKYPIH 88
            :||||.:|.||   .||.. ||.::.......:...|. .:|.:...|:|.||||:::|||| :|
Human    43 RPNIILVLTDD---QDVEL-GSMQVMNKTRRIMEQGGAHFINAFVTTPMCCPSRSSILTGKY-VH 102

  Fly    89 TGMQHTVLYAAEPRGLPL-----EEKILPQYLNELGYTSHIAGKWHLGHWKLKYTPLYRGFSSHV 148
               .|......|....|.     |.:....|||..||.:...|| :|..:...|.|  .|:...|
Human   103 ---NHNTYTNNENCSSPSWQAQHESRTFAVYLNSTGYRTAFFGK-YLNEYNGSYVP--PGWKEWV 161

  Fly   149 GFWSGHQDYNDHTAVENNQWGLDMRNGTQVAYDLHGHYTTDVITDHSVK---------------V 198
            |.....:.|| :|...|   |:..::|:..:.|    |.||:||:.||.               :
Human   162 GLLKNSRFYN-YTLCRN---GVKEKHGSDYSKD----YLTDLITNDSVSFFRTSKKMYPHRPVLM 218

  Fly   199 IANHNATKGP---------LFLYVAHAACHSSNPYNPLPVPDNDVI-------KMSHI--PNYKR 245
            :.:|.|..||         ||   .:|:.|.:..||..|.||...|       |..|:  .|..:
Human   219 VISHAAPHGPEDSAPQYSRLF---PNASQHITPSYNYAPNPDKHWIMRYTGPMKPIHMEFTNMLQ 280

  Fly   246 RKFAAMVSKMDNSVGQIVDQLRKSNMLENSIIIFSSDNGGPAQGFNLNFASNYPLKGVKNTLWEG 310
            ||....:..:|:|:..|.:.|.::..|:|:.|::::|:|.....|.|       :|| |:..:|.
Human   281 RKRLQTLMSVDDSMETIYNMLVETGELDNTYIVYTADHGYHIGQFGL-------VKG-KSMPYEF 337

  Fly   311 GVRAAGLMWSPLLKKSQRVSNQTM--HI---IDWLPTLLEAAGGQPALSNLSKQIDGQSIWRALV 370
            .:|.      |...:...|....:  ||   ||..||:|:.||     .::...:||:||.:.|.
Human   338 DIRV------PFYVRGPNVEAGCLNPHIVLNIDLAPTILDIAG-----LDIPADMDGKSILKLLD 391

  Fly   371 QDKASPRLN------------------VLHNIDD--IWGSAALSVGDWKLVKGTNYRGSWDGWYG 415
            .::...|.:                  :||..|:  :.......:..::.||....|..:.....
Human   392 TERPVNRFHLKKKMRVWRDSFLVERGKLLHKRDNDKVDAQEENFLPKYQRVKDLCQRAEYQTACE 456

  Fly   416 PAGERDPRLYDWQLV----GRSRAGKALEALKMLPSRADQQRIRAAATVSCP---GQSSQGTSC 472
            ..|::      ||.|    |:.:..|....:::..|||....:        |   ||.|:..:|
Human   457 QLGQK------WQCVEDATGKLKLHKCKGPMRLGGSRALSNLV--------PKYYGQGSEACTC 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8646	NP_610807.3	AslA	25..459	CDD:225661	122/501 (24%)
		4-S	26..405	CDD:293753	112/442 (25%)
		DUF4976	<462..531	CDD:303608	5/14 (36%)
SULF2	NP_001373981.1	G6S	43..385	CDD:293766	103/382 (27%)
		DUF3740	529..662	CDD:403667
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	560..588
		ALP_like	<750..799	CDD:419962
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3119
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810