DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8646 and Arsi

DIOPT Version :9

Sequence 1:	NP_610807.3	Gene:	CG8646 / 36394	FlyBaseID:	FBgn0033763	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_001033588.1	Gene:	Arsi / 545260	MGIID:	2670959	Length:	573	Species:	Mus musculus

Alignment Length:	535	Identity:	211/535 - (39%)
Similarity:	289/535 - (54%)	Gaps:	77/535 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 PAKPNIIFILADDLGFNDVGFHGSAEIPTPNIDALAYSGIILNRYYVAPICTPSRSALMTGKYPI 87
            |..|:|||||.||.|::|||:||| :|.||.:|.||..|:.|..||:.||||||||.|:||:|.|
Mouse    44 PQPPHIIFILTDDQGYHDVGYHGS-DIETPTLDRLAAEGVKLENYYIQPICTPSRSQLLTGRYQI 107

  Fly    88 HTGMQHTVLYAAEPRGLPLEEKILPQYLNELGYTSHIAGKWHLGHWKLKYTPLYRGFSSHVGFWS 152
            |||:||:::...:|..|||::..|||.|.|.||::|:.||||||.::.:..|..|||.:.:|..:
Mouse   108 HTGLQHSIIRPRQPNCLPLDQVTLPQKLQEAGYSTHMVGKWHLGFYRKECLPTRRGFDTFLGSLT 172

  Fly   153 GHQDYNDHTAVEN-NQWGLDMRNGTQVAYDLHGHYTTDVITDHSVKVIANHNATKGPLFLYVAHA 216
            |:.||..:...:. ...|.|:..|..||:.|.|.|:|.:....:..::|:|| .:.|||||||..
Mouse   173 GNVDYYTYDNCDGPGVCGFDLHEGESVAWGLSGQYSTMLYAQRASHILASHN-PQNPLFLYVAFQ 236

  Fly   217 ACHSSNPYNPLPVPDNDVIKMSHIPNYKRRKFAAMVSKMDNSVGQIVDQLRKSNMLENSIIIFSS 281
            |.|:     ||..|...:.:...:.|..|||:||||:.||.:|..|...|::.....||:|||||
Mouse   237 AVHT-----PLQSPREYLYRYRTMGNVARRKYAAMVTCMDEAVRNITWALKRYGFYNNSVIIFSS 296

  Fly   282 DNGGPAQGFNLNFASNYPLKGVKNTLWEGGVRAAGLMWSPLLKKSQRVSNQTMHIIDWLPTLLEA 346
            ||||  |.|  :..||:||:|.|.|.||||||..|.:.||||||.:|.|...:||.||.|||:..
Mouse   297 DNGG--QTF--SGGSNWPLRGRKGTYWEGGVRGLGFVHSPLLKKKRRTSRALVHITDWYPTLVGL 357

  Fly   347 AGGQPALSNLSKQIDGQSIWRALVQDKASPRLNVLHNID---------------DIWGS---AAL 393
            |||   .::.:..:||..:|.|:.:.:||||..:|||||               .||.:   ||:
Mouse   358 AGG---TTSAADGLDGYDVWPAISEGRASPRTEILHNIDPLYNHARHGSLEGGFGIWNTAVQAAI 419

  Fly   394 SVGDWKLVKGTNYRGSWDGWYGPAGERDPRLYDWQLVGRSRAGKALEALKMLPSRADQQRIRAAA 458
            .||:|||:.|                 ||...||                          |....
Mouse   420 RVGEWKLLTG-----------------DPGYGDW--------------------------IPPQT 441

  Fly   459 TVSCPGQSSQGTSCVATAFSAPCLFHIRDDPCEQYNLAKQYPEVVNALMTELERFNATAVPPSNK 523
            ..|.|| |......:|:...|..||:|..||.|:.:||.|.|:||..|:..|..:|.||:|....
Mouse   442 LASFPG-SWWNLERMASIRQAVWLFNISADPYEREDLAGQRPDVVRTLLARLADYNRTAIPVRYP 505

  Fly   524 PADPRADPRFWNYTW 538
            .|:|||.|.|....|
Mouse   506 AANPRAHPDFNGGAW 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8646	NP_610807.3	AslA	25..459	CDD:225661	179/452 (40%)
		4-S	26..405	CDD:293753	174/397 (44%)
		DUF4976	<462..531	CDD:303608	27/68 (40%)
Arsi	NP_001033588.1	AslA	47..492	CDD:225661	198/502 (39%)
		4-S	47..478	CDD:293753	191/488 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	515..550		2/6 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	307	1.000	Domainoid score	I1340
eggNOG	1	0.900	-	-		E1_COG3119
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	352	1.000	Inparanoid score	I2247
Isobase	1	0.950	-	1.056642	Normalized mean entropy	S4850
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D375140at33208
OrthoFinder	1	1.000	-	-		FOG0000852
OrthoInspector	1	1.000	-	-		mtm8720
orthoMCL	1	0.900	-	-		OOG6_100690
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1868
SonicParanoid	1	1.000	-	-		X499
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.710