Protein Alignment CG8646 and Galns

DIOPT Version :10

• Sequence 1: NP_610807.3
• Gene: CG8646 / 36394
• FlyBaseID: FBgn0033763
• Length: 562
• Species: Drosophila melanogaster
• Sequence 2: NP_057931.3
• Gene: Galns / 50917
• MGIID: 1355303
• Length: 520
• Species: Mus musculus
• Alignment Length: 561
• Identity: 144/561 - (25%)
• Similarity: 235/561 - (41%)
• Gaps: 136/561 - (24%)

  Fly     4 LWLICLLLPIIDAAEVEKSPAKPNIIFILADDLGFNDVGFHGSAEIPTPNIDALAYSGIILNRYY 68
            |.|:...|.::.|.    :|..|||:.:|.||:|:.|:|.:|.....|||:|.:|..|::...:|
Mouse    10 LLLVLSALGLLAAG----APQPPNIVLLLMDDMGWGDLGVNGEPSRETPNLDRMAAEGMLFPSFY 70

  Fly    69 VA-PICTPSRSALMTGKYPIHTGMQHTVLYAAE---PR----GLPLEEKILPQYLNELGYTSHIA 125
            .| |:|:|||:||:||:.||..|...|..:|..   |:    |:|..|.:||:.|.:.|||:.|.
Mouse    71 SANPLCSPSRAALLTGRLPIRNGFYTTNAHARNAYTPQEIMGGIPNSEHLLPELLKKAGYTNKIV 135

  Fly   126 GKWHLGHWKLKYTPLYRGFSSHVGFWSGHQDYNDHTAVEN----NQWGLDMRNGTQVAYDLHGHY 186
            ||||||| :.::.||..||....|..:.|....|:.|..|    ..|            ::.|.:
Mouse   136 GKWHLGH-RPQFHPLKHGFDEWFGSPNCHFGPYDNKAKPNIPVYRDW------------EMVGRF 187

  Fly   187 --------------TTDVITDHSVKVIANHNATKGPLFLYVAHAACHSSNPYNPLPVPDNDVIKM 237
                          .|.:.|..::..|...:|.:.|.|||.|                    |..
Mouse   188 YEEFPINRKTGEANLTQLYTQEALDFIQTQHARQSPFFLYWA--------------------IDA 232

  Fly   238 SHIPNYKRRKFAA---------MVSKMDNSVGQIVDQLRKSNMLENSIIIFSSDNG-----GPAQ 288
            :|.|.|..|:|..         .|.::|:|||:|:..|:...:.:|:.:.|:||||     .|.:
Mouse   233 THAPVYASRQFLGTSLRGRYGDAVREIDDSVGKILSLLQNLGISKNTFVFFTSDNGAALISAPNE 297

  Fly   289 GFNLNFASNYPLKGVKNTLWEGGVRAAGLMWSPLLKKSQRVSNQTMHIIDWLPTLLEAAGGQPAL 353
            |     .||.|....|.|.:|||:|...:.|.|....:.:||:|...|:|...|.|..||.:|..
Mouse   298 G-----GSNGPFLCGKQTTFEGGMREPAIAWWPGHIAAGQVSHQLGSIMDLFTTSLSLAGLKPPS 357

  Fly   354 SNLSKQIDGQSIWRALVQDKASPRLNVLHNIDDIWGSAALSVGDWKLVKGTNYRGSWDGWYGPAG 418
            ..:   |||..:...:::.:...|....:..:.:   .|:::|.:|....| :..||:.:
Mouse   358 DRV---IDGLDLLPTMLKGQMMDRPIFYYRGNTL---MAVTLGQYKAHLWT-WTNSWEEF----- 410

  Fly   419 ERDPRLYDWQLVGRSRAGKALEALKMLPSRADQQRIRAAATVSCPGQSSQG--TSCVATAFSAPC 481
                                                 ...|..||||:..|  |.........|.
Mouse   411 -------------------------------------TQGTDFCPGQNVSGVTTHTQEEHTELPL 438

  Fly   482 LFHIRDDPCEQYNL---AKQYPEVVNALMTELERFNATAVP 519
            :||:..||.|::.|   :.:|.:.::.....::....:.||
Mouse   439 IFHLGRDPGERFPLSFHSDEYQDALSRTTQVVQEHQKSLVP 479

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8646	NP_610807.3	4-S	26..405	CDD:293753	119/418 (28%)
		DUF4976	<480..510	CDD:419068	8/32 (25%)
Galns	NP_057931.3	Catalytic domain. /evidence=ECO:0000250	24..377		116/393 (30%)
		GALNS	27..492	CDD:293776	139/540 (26%)