Protein Alignment CG8646 and ARSD

DIOPT Version :10

• Sequence 1: NP_610807.3
• Gene: CG8646 / 36394
• FlyBaseID: FBgn0033763
• Length: 562
• Species: Drosophila melanogaster
• Sequence 2: NP_001660.2
• Gene: ARSD / 414
• HGNCID: 717
• Length: 593
• Species: Homo sapiens
• Alignment Length: 623
• Identity: 149/623 - (23%)
• Similarity: 237/623 - (38%)
• Gaps: 190/623 - (30%)

  Fly     4 LWLICLLLPIIDAAEVEKSPA-KPNIIFILADDLGFNDVGFHGSAEIPTPNIDALAYSGIILNRY 67
            |..:||||   ...|.:.:.| ||||:.|:|||||..|:|.:|:..:.|||||.||..|:.|.::
Human    21 LLFLCLLL---KTCEPKTANAFKPNILLIMADDLGTGDLGCYGNNTLRTPNIDQLAEEGVRLTQH 82

  Fly    68 Y-VAPICTPSRSALMTGKYPIHTGMQ-----HTVLYAAEPRGLPLEEKILPQYLNELGYTSHIAG 126
            . .||:|||||:|.:||::...:||.     ..:.:.|...|||..|....:.|.:.||.:.:.|
Human    83 LAAAPLCTPSRAAFLTGRHSFRSGMDASNGYRALQWNAGSGGLPENETTFARILQQHGYATGLIG 147

  Fly   127 KWHLG--------HWKLKYTPLYRGFSSHVGFWSGHQDY---------ND---------HTAVEN 165
            |||.|        |.   :.||..||           ||         ||         ..|:..
Human   148 KWHQGVNCASRGDHC---HHPLNHGF-----------DYFYGMPFTLTNDCDPGRPPEVDAALRA 198

  Fly   166 NQWG----------------------LDMRNGTQVA-----YDLHGHYTTDVITDHSVKVIANHN 203
            ..||                      :..|..|.:|     :.:..:.:...:...:..::.||:
Human   199 QLWGYTQFLALGILTLAAGQTCGFFSVSARAVTGMAGVGCLFFISWYSSFGFVRRWNCILMRNHD 263

  Fly   204 ATKGPLFL----------YVAHAACHSSNPYNPLPVPDNDVIKMS----HIPNYKRRKFAAM--- 251
            .|:.|:.|          .|::...|...|:         ::.:|    |||......|...
Human   264 VTEQPMVLEKTASLMLKEAVSYIERHKHGPF---------LLFLSLLHVHIPLVTTSAFLGKSQH 319

  Fly   252 ------VSKMDNSVGQIVDQLRKSNMLENSIIIFSSDNGGPAQ---------GFNLNFASNYPLK 301
                  |.:||..:|::::.:..:.:..::...|:||:||..:         |:|..:.....:.
Human   320 GLYGDNVEEMDWLIGKVLNAIEDNGLKNSTFTYFTSDHGGHLEARDGHSQLGGWNGIYKGGKGMG 384

  Fly   302 GVKNTLWEGGVRAAGLMWSPLLKKSQRVSNQTMHIIDWLPTLLEAAGGQPALSNLSKQIDGQSIW 366
            |     ||||:|..|:...|.:..:.||..:...::|..||:::..||:.....:   |||.|:.
Human   385 G-----WEGGIRVPGIFHWPGVLPAGRVIGEPTSLMDVFPTVVQLVGGEVPQDRV---IDGHSLV 441

  Fly   367 RALVQDKASPRLNVL-------------HNIDDIWGSAALSVGDWKLVKGT---NYRGSWDGWYG 415
            ..|...:|......|             |..|.  ||.      ||:...|   :..|: ...||
Human   442 PLLQGAEARSAHEFLFHYCGQHLHAARWHQKDS--GSV------WKVHYTTPQFHPEGA-GACYG 497

  Fly   416 P-----AGE-----RDPRLYDWQLVGRSRAGKALEALKMLPSRADQQRI------RAAATVSCPG 464
            .     :||     |.|.|:|   :.|..:    ||..:.|   |.:.:      |..|.||
Human   498 RGVCPCSGEGVTHHRPPLLFD---LSRDPS----EARPLTP---DSEPLYHAVIARVGAAVS--- 549

  Fly   465 QSSQGTSCVATAFS----------APCLFHIRDDPCEQ 492
            :..|..|.|...||          .||..|.....|.:
Human   550 EHRQTLSPVPQQFSMSNILWKPWLQPCCGHFPFCSCHE 587

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8646	NP_610807.3	4-S	26..405	CDD:293753	114/485 (24%)
		DUF4976	<480..510	CDD:419068	4/13 (31%)
ARSD	NP_001660.2	ALP_like	40..563	CDD:474031	136/575 (24%)