DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8646 and ARSB

DIOPT Version :9

Sequence 1:	NP_610807.3	Gene:	CG8646 / 36394	FlyBaseID:	FBgn0033763	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_000037.2	Gene:	ARSB / 411	HGNCID:	714	Length:	533	Species:	Homo sapiens

Alignment Length:	564	Identity:	201/564 - (35%)
Similarity:	299/564 - (53%)	Gaps:	100/564 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LWLICLLLPIIDAAEVEKSPAKPNIIFILADDLGFNDVGFHGSAEIPTPNIDALAYSGIILNRYY 68
            |.|:.||.|....|...:   .|:::|:||||||:|||||||| .|.||::||||..|::|:.||
Human    26 LLLLLLLAPPGSGAGASR---PPHLVFLLADDLGWNDVGFHGS-RIRTPHLDALAAGGVLLDNYY 86

  Fly    69 VAPICTPSRSALMTGKYPIHTGMQHTVLYAAEPRGLPLEEKILPQYLNELGYTSHIAGKWHLGHW 133
            ..|:||||||.|:||:|.|.||:||.:::..:|..:||:||:|||.|.|.|||:|:.||||||.:
Human    87 TQPLCTPSRSQLLTGRYQIRTGLQHQIIWPCQPSCVPLDEKLLPQLLKEAGYTTHMVGKWHLGMY 151

  Fly   134 KLKYTPLYRGFSSHVGFWSGHQDYNDH------TAVENNQWGLDMRNGTQVAYDLHGHYTTDVIT 192
            :.:..|..|||.::.|:..|.:||..|      .|:...:..||.|:|.:||......|:|::.|
Human   152 RKECLPTRRGFDTYFGYLLGSEDYYSHERCTLIDALNVTRCALDFRDGEEVATGYKNMYSTNIFT 216

  Fly   193 DHSVKVIANHNATKGPLFLYVAHAACHSSNPYNPLPVPDNDVIKMSHIPNYKRRKFAAMVSKMDN 257
            ..::.:|.||...| |||||:|..:.|     .||.||:..:.....|.:..|..:|.|||.||.
Human   217 KRAIALITNHPPEK-PLFLYLALQSVH-----EPLQVPEEYLKPYDFIQDKNRHHYAGMVSLMDE 275

  Fly   258 SVGQIVDQLRKSNMLENSIIIFSSDNGGPAQGFNLNFASNYPLKGVKNTLWEGGVRAAGLMWSPL 322
            :||.:...|:.|.:..|::.|||:||||.    .|...:|:||:|.|.:|||||||..|.:.|||
Human   276 AVGNVTAALKSSGLWNNTVFIFSTDNGGQ----TLAGGNNWPLRGRKWSLWEGGVRGVGFVASPL 336

  Fly   323 LKKSQRVSNQTMHIIDWLPTLLEAAGGQPALSNLSKQIDGQSIWRALVQDKASPRLNVLHNIDDI 387
            ||:....:.:.:||.||||||::.|.|.   :|.:|.:||..:|:.:.:...|||:.:|||||..
Human   337 LKQKGVKNRELIHISDWLPTLVKLARGH---TNGTKPLDGFDVWKTISEGSPSPRIELLHNIDPN 398

  Fly   388 WGS-----------------------------AALSVGDWKLVKGTNYRGSWDGWYGPAGERDPR 423
            :..                             ||:..|:|||:  |.|.|. ..|:.|     |.
Human   399 FVDSSPCPRNSMAPAKDDSSLPEYSAFNTSVHAAIRHGNWKLL--TGYPGC-GYWFPP-----PS 455

  Fly   424 LYDWQLVGRSRAGKALEALKMLPSRADQQRIRAAATVSCPGQSSQGTSCVATAFSAPCLFHIRDD 488
            .|:               :..:||                  |...|..:       .||.|..|
Human   456 QYN---------------VSEIPS------------------SDPPTKTL-------WLFDIDRD 480

  Fly   489 PCEQYNLAKQYPEVVNALMTELERFNATAVPPSNKPADPRADPR 532
            |.|:::|:::||.:|..|::.|:.::..:||......|||.||:
Human   481 PEERHDLSREYPHIVTKLLSRLQFYHKHSVPVYFPAQDPRCDPK 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8646	NP_610807.3	AslA	25..459	CDD:225661	174/468 (37%)
		4-S	26..405	CDD:293753	165/413 (40%)
		DUF4976	<462..531	CDD:303608	19/68 (28%)
ARSB	NP_000037.2	AslA	41..489	CDD:225661	183/512 (36%)
ARSB	NP_000037.2	4-S	45..488	CDD:293753	182/504 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	290	1.000	Domainoid score	I1555
eggNOG	1	0.900	-	-		E1_COG3119
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	350	1.000	Inparanoid score	I2283
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D375140at33208
OrthoFinder	1	1.000	-	-		FOG0000852
OrthoInspector	1	1.000	-	-		mtm8485
orthoMCL	1	0.900	-	-		OOG6_100690
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1868
SonicParanoid	1	1.000	-	-		X499
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.760