Protein Alignment CG8646 and ARSA

DIOPT Version :9

• Sequence 1: NP_610807.3
• Gene: CG8646 / 36394
• FlyBaseID: FBgn0033763
• Length: 562
• Species: Drosophila melanogaster
• Sequence 2: XP_016884289.1
• Gene: ARSA / 410
• HGNCID: 713
• Length: 547
• Species: Homo sapiens
• Alignment Length: 599
• Identity: 160/599 - (26%)
• Similarity: 241/599 - (40%)
• Gaps: 146/599 - (24%)

  Fly     9 LLLPIIDAAEVEKSPAKPNIIFILADDLGFNDVGFHGSAEIPTPNIDALAYSGIILNRYYV-API 72
            |||.:.....|.:   .|||:.|.|||||:.|:|.:|.....|||:|.||..|:....:|| ..:
Human     9 LLLALAAGLAVAR---PPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSL 70

  Fly    73 CTPSRSALMTGKYPIHTGMQHTVLYAAEPRGLPLEEKILPQYLNELGYTSHIAGKWHLGHW-KLK 136
            |||||:||:||:.|:..||...||..:...||||||..:.:.|...||.:.:|||||||.. :..
Human    71 CTPSRAALLTGRLPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEGA 135

  Fly   137 YTPLYRGFSSHVGFWSGHQDYNDHTAVEN---------NQWGLD--------MRN---------- 174
            :.|.::||...:|....|    |....:|         ...|.|        :.|
Human   136 FLPPHQGFHRFLGIPYSH----DQGPCQNLTCFPPATPCDGGCDQGLVPIPLLANLSVEAQPPWL 196

  Fly   175 -GTQVAYDLHGHYTTDVITDHSVKVIANHNATKGPLFLYVAHAACHSSNPYNPLPVPDNDVIKMS 238
             |.:..|....|           .::|:......|.|||  :|:.|                  :
Human   197 PGLEARYMAFAH-----------DLMADAQRQDRPFFLY--YASHH------------------T 230

  Fly   239 HIPNYKRRKFAA---------MVSKMDNSVGQIVDQLRKSNMLENSIIIFSSDNGGPAQGFNLNF 294
            |.|.:..:.||.         .:.::|.:||.::..:....:||.:::||::|||......:...
Human   231 HYPQFSGQSFAERSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGG 295

  Fly   295 ASNYPLKGVKNTLWEGGVRAAGL-MWSPLLKKSQRVSNQTMHIIDWLPTLLEAAGGQPALSNLSK 358
            .|.. |:..|.|.:|||||...| .|...:  :..|:::....:|.||||...||.  .|.|::
Human   296 CSGL-LRCGKGTTYEGGVREPALAFWPGHI--APGVTHELASSLDLLPTLAALAGA--PLPNVT- 354

  Fly   359 QIDGQSIWRALVQDKASPRLNVL---HNIDDIWGSAALSVGDWKLVKGTNYRGSWDGWYGPAGER 420
             :||..:...|:....|||.::.   ...|::.|..|:..|.:|....|  :|:...|..|
Human   355 -LDGFDLSPLLLGTGKSPRQSLFFYPSYPDEVRGVFAVRTGKYKAHFFT--QGNPSPWIPP---- 412

  Fly   421 DPRLYDWQLVGRSRAGKALEALKMLPSRADQQRIRAAATVSC------PGQSSQGT----SCVA- 474
             |.|                   :.|.|:.:......|...|      ||.:...|    :|.|
Human   413 -PDL-------------------LTPPRSPRSLAPPLALALCTELAPSPGSAHSDTTADPACHAS 457

  Fly   475 ---TAFSAPCLFHIRDDPCEQYNL----AKQYPEVVNA------LMTELE---RFNATAVPPSNK 523
               ||...|.|:.:..||.|.|||    |...|||:.|      |..:|:   .|..:.|.....
Human   458 SSLTAHEPPLLYDLSKDPGENYNLLGGVAGATPEVLQALKQLQLLKAQLDAAVTFGPSQVARGED 522

  Fly   524 PA-----DPRADPR 532
            ||     .|...||
Human   523 PALQICCHPGCTPR 536

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8646	NP_610807.3	AslA	25..459	CDD:225661	125/476 (26%)
		4-S	26..405	CDD:293753	117/421 (28%)
		DUF4976	<462..531	CDD:303608	28/100 (28%)
ARSA	XP_016884289.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3119
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810