DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8646 and CG7402

DIOPT Version :9

Sequence 1:	NP_610807.3	Gene:	CG8646 / 36394	FlyBaseID:	FBgn0033763	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_649023.1	Gene:	CG7402 / 39994	FlyBaseID:	FBgn0036768	Length:	579	Species:	Drosophila melanogaster

Alignment Length:	553	Identity:	230/553 - (41%)
Similarity:	334/553 - (60%)	Gaps:	37/553 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 KPNIIFILADDLGFNDVGFHGSAEIPTPNIDALAYSGIILNRYYVAPICTPSRSALMTGKYPIHT 89
            ||||:.||.||:|.|||.||||.:|.|||||||||:||:||::||..:|||||:.|:||||||||
  Fly    27 KPNIVIILIDDMGMNDVSFHGSNQILTPNIDALAYNGILLNKHYVPNLCTPSRATLLTGKYPIHT 91

  Fly    90 GMQHTVLYAAEPRGLPLEEKILPQYLNELGYTSHIAGKWHLGHWKLKYTPLYRGFSSHVGFWSGH 154
            ||||.|:...||.|||..|:::|:...:.||::|:.||||||.|:...||..|||..|.|:::|:
  Fly    92 GMQHFVIITDEPWGLPQRERLMPEIFRDAGYSTHLVGKWHLGFWRKDLTPTMRGFDHHFGYYNGY 156

  Fly   155 QDYNDHTA---VENNQWGLDMRNGTQVAYDLHGHYTTDVITDHSVKVIANHNATKGPLFLYVAHA 216
            .||.||..   ..|...|||.|...:...:.:|.|.|:..|..:.::|..|:.:| |||:.::|.
  Fly   157 IDYYDHQVRMLDRNYSAGLDFRRDLEPCPEANGTYATEAFTSEAKRIIEQHDKSK-PLFMVLSHL 220

  Fly   217 ACHSSNPYNPLPVPDNDVIKMSHIPNYKRRKFAAMVSKMDNSVGQIVDQLRKSNMLENSIIIFSS 281
            |.|:.|..:|:..|:.:|.|..||.:.|||.:|.|:|.:|.||.|.:..|:.:.||.||||:..|
  Fly   221 AVHTGNEDSPMQAPEEEVAKFPHIRDPKRRTYAGMISSLDKSVAQTIGALKDNGMLNNSIILLYS 285

  Fly   282 DNGGPAQGFNLNFASNYPLKGVKNTLWEGGVRAAGLMWSPLLKKSQRVSNQTMHIIDWLPTLLEA 346
            |||.|..|.:.|..||||.:|.|.:.||||:|:||.:||||||:...||||.:|.:||||||..|
  Fly   286 DNGAPTIGIHSNAGSNYPYRGQKESPWEGGIRSAGALWSPLLKERGYVSNQAIHAVDWLPTLAGA 350

  Fly   347 AGGQPALSNLSKQ--IDGQSIWRALV-QDKASPRLNVLHNIDDIWGSAALSVGDWKLVKGTNYRG 408
            ||     .:|.:.  :||.::|..|. .::..|| .::|.:|:::|.::......|.|.|::::|
  Fly   351 AG-----VSLPQDLPLDGINLWPMLSGNEEPKPR-TMIHVLDEVFGYSSYMRDTLKYVNGSSFKG 409

  Fly   409 SWDGWYG--PAGERDP--RLYDWQLVGRSRAGKALEALKMLPSRA---DQ-QRIRAAATVSCP-- 463
            .:|.|.|  ...|.||  ..|:..::       |.:...:|.:|.   |: :::|:.||.:||
  Fly   410 RYDQWLGELETNEDDPLGESYEQHVL-------ASDVQSLLGNRGLTKDRIRQMRSEATETCPPI 467

  Fly   464 -GQSSQGTSCVATAFSAPCLFHIRDDPCEQYNLAKQYPEVVNALMTELERFNATAVPPSNKP-AD 526
             ||:...:........|||.|.:..||||:||||:.||..:..|..|||:...||:|.:..| :|
  Fly   468 EGQNPLESHFKCEPLKAPCFFDLAKDPCERYNLAQMYPLQLQQLADELEQIRKTAIPSARVPHSD 532

  Fly   527 PRADPRFWNYTWTNFGDYQNNDLDTFSGDITLA 559
            .||:|.|.|..|    ::.|| .||.||..|.:
  Fly   533 SRANPTFHNGNW----EWWNN-TDTQSGSGTFS 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8646	NP_610807.3	AslA	25..459	CDD:225661	188/447 (42%)
		4-S	26..405	CDD:293753	174/384 (45%)
		DUF4976	<462..531	CDD:303608	29/72 (40%)
CG7402	NP_649023.1	PRK13759	25..459	CDD:237491	188/445 (42%)
CG7402	NP_649023.1	4-S	28..436	CDD:293753	182/421 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	294	0.414	Domainoid score	I1467
eggNOG	1	0.900	-	-		E1_COG3119
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	351	1.000	Inparanoid score	I2236
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D375140at33208
OrthoFinder	1	1.000	-	-		FOG0000852
OrthoInspector	1	1.000	-	-		mtm6503
orthoMCL	1	0.900	-	-		OOG6_100690
Panther	1	1.100	-	-	P	PTHR10342
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X499
	10	9.870