DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8646 and CG18278

DIOPT Version :9

Sequence 1:	NP_610807.3	Gene:	CG8646 / 36394	FlyBaseID:	FBgn0033763	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_725289.1	Gene:	CG18278 / 36487	FlyBaseID:	FBgn0033836	Length:	492	Species:	Drosophila melanogaster

Alignment Length:	532	Identity:	124/532 - (23%)
Similarity:	205/532 - (38%)	Gaps:	120/532 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LICLLLPIIDAAEVEKSPAKPNIIFILADDLGFNDVGFHGSAEIPTPN-IDALAYSGIIL-NRYY 68
            ||.|:|..:.....||   .|||:.||:||   .||...|.  .|..: |:.|.:.|.:. |.|.
  Fly     7 LIILVLACLGNTASEK---LPNILLILSDD---QDVELRGM--FPMEHTIEMLGFGGALFHNAYT 63

  Fly    69 VAPICTPSRSALMTGKYPIHTGMQHTVL----------YAAEPRGLPLEEKILPQYLNELGYTSH 123
            .:|||.|:|::|:||.|..:.|.::..:          .|.|||.||.   ||.|:    ||.:.
  Fly    64 PSPICCPARTSLLTGMYAHNHGTRNNSVSGGCYGPHWRRALEPRALPY---ILQQH----GYNTF 121

  Fly   124 IAGKWHLGHWKLKYTPLYRGFSSHVGFWSGHQDYNDHTAVENNQWGLDMRNGTQVAYDLHGHYTT 188
            ..||:...:|.....|  :|::...|. .|:..|.::|..||:         ..|.|:  ..|.|
  Fly   122 FGGKYLNQYWGAGDVP--KGWNHFYGL-HGNSRYYNYTLRENS---------GNVHYE--STYLT 172

  Fly   189 DVITDHSVKVIANHNATKGPLFLYVAHAACHSSNPYNPLP-------------VPDNDVIKMS-- 238
            |::.|.:...:.|...:..|.|..||..|.|  .|:.|.|             .|..:.:|..
  Fly   173 DLLRDRAADFLRNATQSSEPFFAMVAPPAAH--EPFTPAPRHEGVFSHIEALRTPSFNQVKQDKH 235

  Fly   239 -------HIPN--------YKRRKFAAMVSKMDNSVGQIVDQLRKSNMLENSIIIFSSDNGGPAQ 288
                   .:||        |.::::..::: :|..|..::..|..:..|||:.||::||||....
  Fly   236 WLVRAARRLPNETINTIDTYFQKRWETLLA-VDELVVTLMGVLNDTQSLENTYIIYTSDNGYHVG 299

  Fly   289 GFNLNFASNYPLKGVKNTLWEGGVRAAGLMWSPLLKKSQRVSNQTMHIIDWLPTLLEAAGGQPAL 353
            .|...|....|        :|..:....|:..|.:.....: :..:.::|..||:|..|.
  Fly   300 QFAQPFDKRQP--------YETDINVPLLIRGPGIAPESHI-DTAVSLVDLAPTILAWAD----- 350

  Fly   354 SNLSKQIDGQSIWRALVQDKASPRLNVLHNIDDIWGSAALSVGD----W----KLVKGT-----N 405
            .:....:||||....|:..:..........:.:.||...|:..:    |    :|.:.|     :
  Fly   351 IDTPSYMDGQSFHELLLNKRRRVPFFERSLLIEYWGEGTLATFNPECPWPEKDRLAQCTPAADCH 415

  Fly   406 YRGSWDGWYG---PAGERDPRL-------------YDWQLVGRSRAGKALEALKMLPSRADQQRI 454
            .:.:|:..|.   ....|:.|:             ||.||........|.:   :||.......:
  Fly   416 CQDAWNNTYACLRNIRHREDRIYCEFRDNENFLEAYDLQLDPFQMTNIAYD---LLPIERALYSL 477

  Fly   455 RAAATVSCPGQS 466
            |......|.|.|
  Fly   478 RLKNLTQCSGHS 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8646	NP_610807.3	AslA	25..459	CDD:225661	115/504 (23%)
		4-S	26..405	CDD:293753	103/433 (24%)
		DUF4976	<462..531	CDD:303608	3/5 (60%)
CG18278	NP_725289.1	G6S	24..467	CDD:293766	112/488 (23%)
CG18278	NP_725289.1	AslA	24..464	CDD:225661	111/482 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3119
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810