Protein Alignment CG8646 and ARSH

DIOPT Version :10

• Sequence 1: NP_610807.3
• Gene: CG8646 / 36394
• FlyBaseID: FBgn0033763
• Length: 562
• Species: Drosophila melanogaster
• Sequence 2: NP_001011719.1
• Gene: ARSH / 347527
• HGNCID: 32488
• Length: 562
• Species: Homo sapiens
• Alignment Length: 601
• Identity: 136/601 - (22%)
• Similarity: 215/601 - (35%)
• Gaps: 185/601 - (30%)

  Fly    24 AKPNIIFILADDLGFNDVGFHGSAEIPTPNIDALAYSGIILNRYY-VAPICTPSRSALMTGKYPI 87
            |:|||:.::|||||..|:..:|:..:.|||||.||..|:.|.::. .|.:|||||:|.:||:|||
Human     5 ARPNIVLLMADDLGVGDLCCYGNNSVSTPNIDRLASEGVRLTQHLAAASMCTPSRAAFLTGRYPI 69

  Fly    88 HTGM------QHTVLYAAEPRGLPLEEKILPQYLNELGYTSHIAGKWHLG--------HWKLKYT 138
            .:||      .....:.....|||..|....:.|...||.:.:.||||||        |.   |.
Human    70 RSGMVSAYNLNRAFTWLGGSGGLPTNETTFAKLLQHRGYRTGLIGKWHLGLSCASRNDHC---YH 131

  Fly   139 PLYRGFSSHVG------------------------------------------------------ 149
            ||..||....|
Human   132 PLNHGFHYFYGVPFGLLSDCQASKTPELHRWLRIKLWISTVALALVPFLLLIPKFARWFSVPWKV 196

  Fly   150 -----------FWSGHQDYNDHTAVENNQWG-LDMRNGTQVAYDLHGHYTTDVITDHSVKVIANH 202
                       |.|.:..|.     ...:|. :.|||...:...:.......::...::..|..:
Human   197 IFVFALLAFLFFTSWYSSYG-----FTRRWNCILMRNHEIIQQPMKEEKVASLMLKEALAFIERY 256

  Fly   203 NATKGPLFLYVAHAACHSSNPYNPLPVPDNDVIKMSHIPNYKRRKFAAMVSKMDNSVGQIVDQLR 267
            .  :.|..|:.:....|:     ||      :.|...:...|..::...|.:||..||:|:|.|.
Human   257 K--REPFLLFFSFLHVHT-----PL------ISKKKFVGRSKYGRYGDNVEEMDWMVGKILDALD 308

  Fly   268 KSNMLENSIIIFSSDNGGPAQ---------GFNLNFASNYPLKGVKNTLWEGGVRAAGLMWSPLL 323
            :..:..::::.|:|||||..:         |:|..:.....:.|     ||||:|..|:...|.:
Human   309 QERLANHTLVYFTSDNGGHLEPLDGAVQLGGWNGIYKGGKGMGG-----WEGGIRVPGIFRWPSV 368

  Fly   324 KKSQRVSNQTMHIIDWLPTLLEAAGGQPALSNLSKQIDGQSIWRALVQDKASPRLN--------- 379
            .::.||.|:...::|..|||....||   :.:..:.||||:: ..|::.:||...:
Human   369 LEAGRVINEPTSLMDIYPTLSYIGGG---ILSQDRVIDGQNL-MPLLEGRASHSDHEFLFHYCGV 429

  Fly   380 VLHNIDDIWGSAALSVGDWKLVKGTNYRGSWDGWYGPAGERDPRLYDWQLVGRSRAGKALEALKM 444
            .||.:.  |...     |...|        |...|     ..|:.|
Human   430 YLHTVR--WHQK-----DCATV--------WKAHY-----VTPKFY------------------- 455

  Fly   445 LPSRADQQRIRAAATVSCPGQSSQGTSCVATAFSAPCLFHIRDDPCEQYNLAKQYPEVVNALMTE 509
                       ...|.:|.|......|...|....|.||.|..||.|...|......:.::::.:
Human   456 -----------PEGTGACYGSGICSCSGDVTYHDPPLLFDISRDPSEALPLNPDNEPLFDSVIKK 509

  Fly   510 LE------RFNATAVP 519
            :|      |...|.||
Human   510 MEAAIREHRRTLTPVP 525

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8646	NP_610807.3	4-S	26..405	CDD:293753	113/477 (24%)
		DUF4976	<480..510	CDD:419068	8/29 (28%)
ARSH	NP_001011719.1	ALP_like	6..530	CDD:474031	135/600 (23%)