Protein Alignment CG8646 and IDS

DIOPT Version :10

• Sequence 1: NP_610807.3
• Gene: CG8646 / 36394
• FlyBaseID: FBgn0033763
• Length: 562
• Species: Drosophila melanogaster
• Sequence 2: NP_000193.1
• Gene: IDS / 3423
• HGNCID: 5389
• Length: 550
• Species: Homo sapiens
• Alignment Length: 598
• Identity: 128/598 - (21%)
• Similarity: 206/598 - (34%)
• Gaps: 219/598 - (36%)

  Fly     4 LWL------ICLLLPIIDAAEVEKSPAKP--NIIFILADDLGFNDVGFHGSAEIPTPNIDALA-Y 59
            |||      :|:.|    .:|.:.:....  |::.|:.|||. ..:|.:|...:.:||||.|| :
Human    11 LWLGLVLSSVCVAL----GSETQANSTTDALNVLLIIVDDLR-PSLGCYGDKLVRSPNIDQLASH 70

  Fly    60 SGIILNRYYVAPICTPSRSALMTGKYP-------------IHTGMQHTVLYAAEPRGLPLEEKIL 111
            |.:..|.:....:|.|||.:.:||:.|             :|.|...|:
Human    71 SLLFQNAFAQQAVCAPSRVSFLTGRRPDTTRLYDFNSYWRVHAGNFSTI---------------- 119

  Fly   112 PQYLNELGYTSHIAGKWHLGHWKLKYTPLYRGFSSHVGFWSGHQDYNDHTAVENNQWGLDMRNGT 176
            |||..|.||.:...||                 ..|.|..|.|.|.:.::      |.....:.:
Human   120 PQYFKENGYVTMSVGK-----------------VFHPGISSNHTDDSPYS------WSFPPYHPS 161

  Fly   177 QVAY-----------DLHGHY--TTDVI------------TDHSVKVIANHNATKGPLFLYVAH- 215
            ...|           :||.:.  ..||:            |:.:::::.....:..|.||.|.:
Human   162 SEKYENTKTCRGPDGELHANLLCPVDVLDVPEGTLPDKQSTEQAIQLLEKMKTSASPFFLAVGYH 226

  Fly   216 --------------------------------------------------AACHSSNPYNPLPVP 230
                                                              .|.:.|.||.|:||.
Human   227 KPHIPFRYPKEFQKLYPLENITLAPDPEVPDGLPPVAYNPWMDIRQREDVQALNISVPYGPIPVD 291

  Fly   231 DNDVIKMSHIPNYKRRKFAAMVSKMDNSVGQIVDQLRKSNMLENSIIIFSSDNGGP-------AQ 288
            ....|:.|:.         |.||.:|..||:::..|....:..::||.|:||:|..       |:
Human   292 FQRKIRQSYF---------ASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWALGEHGEWAK 347

  Fly   289 GFNLNFASNYPL----KGVKNTLWEGGVRAAGLMWSPLLKKSQ-----RVSNQTMHIIDWLPTLL 344
            ..|.:.|::.||    .|...:|.|.|.:....: .|....||     |.|...:.::...|||.
Human   348 YSNFDVATHVPLIFYVPGRTASLPEAGEKLFPYL-DPFDSASQLMEPGRQSMDLVELVSLFPTLA 411

  Fly   345 EAAGGQ-------PAL--------SNLSKQIDGQSIWRALVQD---KASPRLNVLHN----IDDI 387
            ..||.|       |:.        .||.|...    :|.|.:|   ..:||..:.::    ..||
Human   412 GLAGLQVPPRCPVPSFHVELCREGKNLLKHFR----FRDLEEDPYLPGNPRELIAYSQYPRPSDI 472

  Fly   388 --WGSAALSVGDWKL----VKGTNYRGS-WDGWYGP-----------AGE-----RDPRLYDWQL 429
              |.|...|:.|.|:    ::..:||.: |.| :.|           |||     .|| |.|..:
Human   473 PQWNSDKPSLKDIKIMGYSIRTIDYRYTVWVG-FNPDEFLANFSDIHAGELYFVDSDP-LQDHNM 535

  Fly   430 VGRSRAGKALEAL 442
            ...|:.|...:.|
Human   536 YNDSQGGDLFQLL 548

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8646	NP_610807.3	4-S	26..405	CDD:293753	107/514 (21%)
		DUF4976	<480..510	CDD:419068
IDS	NP_000193.1	iduronate-2-sulfatase	38..540	CDD:293754	119/557 (21%)