DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8646 and Arsj

DIOPT Version :9

Sequence 1:	NP_610807.3	Gene:	CG8646 / 36394	FlyBaseID:	FBgn0033763	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_001041352.1	Gene:	Arsj / 311013	RGDID:	1307640	Length:	597	Species:	Rattus norvegicus

Alignment Length:	551	Identity:	214/551 - (38%)
Similarity:	291/551 - (52%)	Gaps:	88/551 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 AEVEKSP-------AKPNIIFILADDLGFNDVGFHGSAEIPTPNIDALAYSGIILNRYYVAPICT 74
            |:||:.|       ::|::|||||||.||.|||:||| ||.||.:|.||..|:.|..|||.||||
  Rat    58 AQVEERPEAGTAVTSQPHLIFILADDQGFRDVGYHGS-EIKTPTLDKLAAEGVKLENYYVQPICT 121

  Fly    75 PSRSALMTGKYPIHTGMQHTVLYAAEPRGLPLEEKILPQYLNELGYTSHIAGKWHLGHWKLKYTP 139
            ||||..:||||.||||:||:::...:|..|||:...|||.|.|:||::|:.||||||.::....|
  Rat   122 PSRSQFITGKYQIHTGLQHSIIRPTQPNCLPLDNATLPQKLKEVGYSTHMVGKWHLGFYRKDCMP 186

  Fly   140 LYRGFSSHVGFWSGHQDYNDHTAVEN-NQWGLDMRNGTQVAYDL-HGHYTTDVITDHSVKVIANH 202
            ..|||.:..|...|..||..|...:: ...|.|:......|:|. :|.|:|.:.|....:::|:|
  Rat   187 TKRGFDTFFGSLLGSGDYYTHYKCDSPGVCGYDLYENDNAAWDYDNGIYSTQMYTQRVQQILASH 251

  Fly   203 NATKGPLFLYVAHAACHSSNPYNPLPVPDNDVIKMSHIPNYKRRKFAAMVSKMDNSVGQIVDQLR 267
            :.|| |||||||:.|.||     ||..|.........|.|..||::|||:|.:|.::..:...|:
  Rat   252 DPTK-PLFLYVAYQAVHS-----PLQAPGRYFEHYRSIININRRRYAAMLSCLDEAIHNVTLALK 310

  Fly   268 KSNMLENSIIIFSSDNGG-PAQGFNLNFASNYPLKGVKNTLWEGGVRAAGLMWSPLLKKSQRVSN 331
            :.....|||||:|||||| |..|     .||:||:|.|.|.||||:||.|.:.|||||....|..
  Rat   311 RYGFYNNSIIIYSSDNGGQPTAG-----GSNWPLRGSKGTYWEGGIRAVGFVHSPLLKNKGTVCK 370

  Fly   332 QTMHIIDWLPTLLEAAGGQPALSNLSKQIDGQSIWRALVQDKASPRLNVLHNID----------- 385
            :.:||.||.|||:..|.||   .:...|:||..||..:.:...|||:::|||||
  Rat   371 ELVHITDWYPTLISLAEGQ---IDEDIQLDGYDIWETISEGLRSPRVDILHNIDPIYTKAKNGSW 432

  Fly   386 ----DIWGSA---ALSVGDWKLVKGTNYRGSWDGWYGPAGERDPRLYDWQLVGRSRAGKALEALK 443
                .||.:|   |:.|..|||:.|                 :|...||         ...:|..
  Rat   433 AAGYGIWNTAIQSAIRVQHWKLLTG-----------------NPGYSDW---------VPPQAFS 471

  Fly   444 ML-PSRADQQRIRAAATVSCPGQSSQGTSCVATAFSAPCLFHIRDDPCEQYNLAKQYPEVVNALM 507
            .| |:|...:||..          |.|.|.        .||:|..||.|:.:|:.:||.:|..|:
  Rat   472 NLGPNRWHNERITL----------STGKSI--------WLFNITADPYERVDLSSRYPGIVKKLL 518

  Fly   508 TELERFNATAVPPSNKPADPRADPRFWNYTW 538
            ..|.:||.||||....|.|||::||.....|
  Rat   519 RRLSQFNKTAVPVRYPPKDPRSNPRLNGGVW 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8646	NP_610807.3	AslA	25..459	CDD:225661	182/455 (40%)
		4-S	26..405	CDD:293753	173/399 (43%)
		DUF4976	<462..531	CDD:303608	25/68 (37%)
Arsj	NP_001041352.1	AslA	71..507	CDD:225661	191/494 (39%)
		4-S	74..507	CDD:293753	191/491 (39%)
		DUF4976	<493..>531	CDD:303608	17/37 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D375140at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010