DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8646 and Arse

DIOPT Version :9

Sequence 1:	NP_610807.3	Gene:	CG8646 / 36394	FlyBaseID:	FBgn0033763	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_001041350.1	Gene:	Arse / 310326	RGDID:	1304917	Length:	611	Species:	Rattus norvegicus

Alignment Length:	611	Identity:	155/611 - (25%)
Similarity:	232/611 - (37%)	Gaps:	181/611 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LICLL---LPIIDAAEVEKSPAKPNIIFILADDLGFNDVGFHGSAEIPTPNIDALAYSGIILNRY 67
            |:|::   |..:||  :...|.:||.:.|:|||||..|:|.:|:..|.|||||.||..|:.|.:|
  Rat    14 LLCIVLLGLQYVDA--LRSPPPRPNFLIIMADDLGIGDLGCYGNTSIRTPNIDRLAEDGVRLTQY 76

  Fly    68 YVA-PICTPSRSALMTGKYPIHTGMQ----HTVL-YAAEPRGLPLEEKILPQYLNELGYTSHIAG 126
            ..| .:|||||:|.:||:|||.:||.    |.|| :||...|||.:|....:.|...||.:.:.|
  Rat    77 LAAESVCTPSRAAFLTGRYPIRSGMTSGNGHRVLQWAAGAGGLPPKEITFARILQGQGYVTGLVG 141

  Fly   127 KWHLG-----HWKLKYTPLYRGFSSHVGF-------WSGHQDYNDHTAVENN------------- 166
            |||||     ...|.:.||..||...:|.       .:|.:.......:|..
  Rat   142 KWHLGLSCRTVSDLCHHPLNHGFHHFLGLPLGMMGDCAGAEPSEKRAGLERRLRGAGRALAAVAV 206

  Fly   167 -----QWGLD-----------------------------------------MRNGTQVAYDLHGH 185
                 .||..                                         |||.|.....|...
  Rat   207 AIAALAWGRGRGLAPACWAPWAAIALGAVAAIFEAGSYVVGGAVARYDCFLMRNATVTQQPLQLD 271

  Fly   186 YTTDVITDHSVKVIANHNATKGPLFLYVAHAACHSSNPYNPLPVPDNDVIKMSHIPNYKRR---- 246
            :.|.::...:...:..|......|||.:.|.       :.||...          |.::.|
  Rat   272 HVTPLLLREAKDFLRRHRHAPFLLFLSLLHT-------HTPLVTS----------PEFRGRSAHG 319

  Fly   247 KFAAMVSKMDNSVGQIVDQLRKSNMLENSIIIFSSDNG----GPAQGFNLNFASNYPLKGVKNT- 306
            ::...|.:||..||||::.|....:.:::::.|:||||    ..|.|..|. .||...:|.|..
  Rat   320 RYGDNVEEMDWVVGQILEVLEHEGLTDSTLVHFTSDNGAWLEAQAGGEQLG-GSNGVFRGGKGMG 383

  Fly   307 LWEGGVRAAGLM-WSPLLKKSQRVSNQTMHIIDWLPTLLEAAGG-QPALSNLSKQIDGQSIWRAL 369
            .||||:|..|:. |..:|.:. ||.:|.:.::|..||::...|| .|:    .::|||:.:...|
  Rat   384 GWEGGIRVPGVFRWPGVLPRG-RVLDQPVSLMDVFPTVVRLGGGVLPS----DREIDGRDLLPLL 443

  Fly   370 VQDKASPRLNVLHNIDDI---WGSAALSVGDWKLVKGTNYRGSWDGW--------YGPAGERDPR 423
                   |....|:..::   :....|....|.      .|.|...|        :.|.|..
  Rat   444 -------RGETWHSAHEVLLHYCEVFLHAVRWV------QRDSGQVWKAHFVTPTFDPLGSG--- 492

  Fly   424 LYDWQLVGRSRAGKALEALKMLPSRADQQRIRAAATVSCPGQSSQGTSCVATAFSAPCLFHIRDD 488
                   ..|.||                  .|||...|.|:..:        ...|.||.:..|
  Rat   493 -------SCSGAG------------------GAAAVCPCVGKVEE--------HDPPLLFELTSD 524

  Fly   489 PCEQYNL---AK--QYPEVVNALMTE 509
            |.|...|   ||  :.|.:..|:.:|
  Rat   525 PGEVRPLRAPAKMSEAPNLTAAITSE 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8646	NP_610807.3	AslA	25..459	CDD:225661	134/532 (25%)
		4-S	26..405	CDD:293753	124/469 (26%)
		DUF4976	<462..531	CDD:303608	14/53 (26%)
Arse	NP_001041350.1	AslA	31..541	CDD:225661	147/581 (25%)
Arse	NP_001041350.1	ALP_like	34..531	CDD:304875	143/568 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3119
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810