DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG8646 and Gns

DIOPT Version :9

Sequence 1:NP_610807.3 Gene:CG8646 / 36394 FlyBaseID:FBgn0033763 Length:562 Species:Drosophila melanogaster
Sequence 2:XP_006241458.1 Gene:Gns / 299825 RGDID:1305877 Length:544 Species:Rattus norvegicus


Alignment Length:607 Identity:141/607 - (23%)
Similarity:240/607 - (39%) Gaps:168/607 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 LLLPIIDAA-EVEKSPAKPNIIFILADDLGFNDVGFHGSAEIPTPNIDAL-AYSGIILNRYYV-A 70
            ||||::... .:..:..:||::.:|.||   .|....|..  |.....|| ...|:..:..|| :
  Rat    21 LLLPLLSGCLGLVGAARRPNVLLLLTDD---QDAELGGMT--PLKKTKALIGEKGMTFSSAYVPS 80

  Fly    71 PICTPSRSALMTGKYPIHTGMQHTVLYA----------AEPRGLPLEEKILPQYLNELGYTSHIA 125
            .:|.|||::::|||||.:..:.:..|..          .||...|...|::      .||.:..|
  Rat    81 ALCCPSRASILTGKYPHNHHVVNNTLEGNCSSKSWQKIQEPYTFPAILKLV------CGYQTFFA 139

  Fly   126 GKWHLGHW------KLKYTPLYRGFSSHVGFW---SGHQDYNDHTAVENNQWGLDMRNGTQVAYD 181
            || :|..:      .|::.||  |:|    :|   ..:..|.::|...|   |...|:|...:.|
  Rat   140 GK-YLNEYGAPDAGGLEHVPL--GWS----YWYALEKNSKYYNYTLSIN---GKARRHGENYSVD 194

  Fly   182 LHGHYTTDVITDHSVKVIANHNATKGPLFLYVAHAACHSSNPYNPLP----------VPDND--- 233
                |.|||:.:.|:..: ::.:...|.|:.::..|.||  |:...|          .|.|.   
  Rat   195 ----YLTDVLANLSLDFL-DYKSNSEPFFMMISTPAPHS--PWTAAPQYQKAFPNVIAPRNKNFN 252

  Fly   234 --------VIKMSHIP----------NYKRRKFAAMVSKMDNSVGQIVDQLRKSNMLENSIIIFS 280
                    :|:.:..|          :..||::..::| :|:.|.::|.:|..:..|:|:.|.::
  Rat   253 IHGTNKHWLIRQAKTPMTNSSIKFLDDAFRRRWQTLLS-VDDLVEKLVKRLDSTGELDNTYIFYT 316

  Fly   281 SDNGGPAQGFNLNFASNYPLKGVKNTLWEGGVRAAGLMWSPLLKKSQRVSNQTMHIIDWLPTLLE 345
            ||||.....|:|      |:.  |..|:|..::...|:..|.:|.:| .|...:..||..||:|:
  Rat   317 SDNGYHTGQFSL------PID--KRQLYEFDIKVPLLVRGPGIKPNQ-TSKMLVSNIDLGPTILD 372

  Fly   346 AAGGQPALSNLSK-QIDGQSIWRALVQDKASPRLNVLHNIDDIWGSAALSVGDWKLVKGTNYRGS 409
            .||     .:|:| |:||.|:            |.:|.             ||..|        :
  Rat   373 LAG-----YDLNKTQMDGTSL------------LPILK-------------GDGNL--------T 399

  Fly   410 WDGWYGPAGERDPRLYDWQLVGRSRAGKALEALKMLPSRADQQRIRAAATVSCPGQSSQGTSCVA 474
            |         |...|.::|..||:.......:|....|:.....:       |....:...:||.
  Rat   400 W---------RSDVLVEYQGEGRNVTDPTCPSLSPGVSQCFPDCV-------CEDAYNNTYACVR 448

  Fly   475 TAFS----APC----------LFHIRDDPCEQYNLAKQY-PEVVNALMTELERFNATAVPPSNKP 524
            |..|    ..|          :::|..||.:..|:||.. ||::..:...|....:.:.|....|
  Rat   449 TLSSMWNLQYCEFDDQEVFVEVYNITADPDQITNIAKSIDPELLGKMNYRLMMLQSCSGPTCRTP 513

  Fly   525 A--DP--RADPRFWNYTWTNFG 542
            .  ||  |.|.|.   .::|.|
  Rat   514 GVFDPGYRFDLRL---MFSNHG 532

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG8646NP_610807.3 AslA 25..459 CDD:225661 113/486 (23%)
4-S 26..405 CDD:293753 105/431 (24%)
DUF4976 <462..531 CDD:303608 20/87 (23%)
GnsXP_006241458.1 G6S 38..487 CDD:293766 125/540 (23%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG3119
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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