DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8646 and Galns

DIOPT Version :9

Sequence 1:	NP_610807.3	Gene:	CG8646 / 36394	FlyBaseID:	FBgn0033763	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	XP_017456734.1	Gene:	Galns / 292073	RGDID:	1565391	Length:	567	Species:	Rattus norvegicus

Alignment Length:	574	Identity:	136/574 - (23%)
Similarity:	224/574 - (39%)	Gaps:	151/574 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LICLLLPIIDAAEVEKSPAKP---------NIIFILADDLGFNDVGFHGSAEIPTPNIDALAYSG 61
            |..:.||::.... :..|..|         ::.::.:..|..:|..|| |.:.|.........|.
  Rat    44 LFSVALPLLSFGR-QGPPHTPKGTAARLGLSLAWLCSRSLDCHDGLFH-SDQGPAATAAGTECSR 106

  Fly    62 IILNRYYVAP-ICTP----SRSALMTGKYPIHTGMQHTVLYAAE---PR----GLPLEEKILPQY 114
            .:..|...|| .|..    ||:||:||:.||..|...|..:|..   |:    |:|..|.:||:.
  Rat   107 TLGCRCSAAPQHCATAHGRSRAALLTGRLPIRNGFYTTNAHARNAYTPQEIMGGIPNSEHLLPEL 171

  Fly   115 LNELGYTSHIAGKWHLGHWKLKYTPLYRGFSSHVGFWSGHQDYNDHTAVEN-------------- 165
            |.:.|||:.|.||||||| :.::.||..||....|..:.|....|:....|
  Rat   172 LKKAGYTNKIVGKWHLGH-RPQFHPLKHGFDEWFGSPNCHFGPYDNKVKPNIPVYRDWEMVGRFY 235

  Fly   166 NQWGLDMRNGTQVAYDLHGHYTTDVITDHSVKVIANHNATKGPLFLYVAHAACHSSNPYNPLPVP 230
            .::.::::.|..        ..|.:....::..|...:|.:.|.|||.|
  Rat   236 EEFPINLKTGEA--------NLTQLYLQEALDFIRTQHARQSPFFLYWA---------------- 276

  Fly   231 DNDVIKMSHIPNYKRRKFAA---------MVSKMDNSVGQIVDQLRKSNMLENSIIIFSSDNG-- 284
                |..:|.|.|..::|..         .|.::|:|||:|:..|:...:.:|:.:.|:||||
  Rat   277 ----IDATHAPVYASKQFLGTSLRGRYGDAVREIDDSVGKILSLLQNLGISKNTFVFFTSDNGAA 337

  Fly   285 ---GPAQGFNLNFASNYPLKGVKNTLWEGGVRAAGLMWSPLLKKSQRVSNQTMHIIDWLPTLLEA 346
               .|.:|     .||.|....|.|.:|||:|...:.|.|....:.:||:|...|:|...|.|..
  Rat   338 LISAPKEG-----GSNGPFLCGKQTTFEGGMREPAIAWWPGHIAAGQVSHQLGSIMDLFTTSLSL 397

  Fly   347 AGGQPALSNLSKQIDGQSIWRALVQDKASPRLNVLHNID-DIW---GSA--ALSVGDWKLVKGTN 405
            ||.:|....:   |||..:...::|.         |.|| .|:   |:.  |:::|.:|....|
  Rat   398 AGLKPPSDRV---IDGLDLLPTMLQG---------HIIDRPIFYYRGNTLMAVTLGQYKAHLWT- 449

  Fly   406 YRGSWDGWYGPAGERDPRLYDWQLVGRSRAGKALEALKMLPSRADQQRIRAAATVSCPGQSSQG- 469
            :..||:.:                    |.|...                      ||||:..|
  Rat   450 WTNSWEEF--------------------RQGIDF----------------------CPGQNVSGV 472

  Fly   470 -TSCVATAFSAPCLFHIRDDPCEQYNL---AKQYPEVVNALMTELERFNATAVP 519
             |.........|.:||:..||.|::.|   :.:|.:.::.....:::...:.||
  Rat   473 TTHTQEEHTELPLIFHLGRDPGERFPLRFTSNEYQDALSRTTQVIQQHQKSLVP 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8646	NP_610807.3	AslA	25..459	CDD:225661	116/488 (24%)
		4-S	26..405	CDD:293753	111/433 (26%)
		DUF4976	<462..531	CDD:303608	16/63 (25%)
Galns	XP_017456734.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3119
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810