Protein Alignment CG8646 and GNS

DIOPT Version :10

• Sequence 1: NP_610807.3
• Gene: CG8646 / 36394
• FlyBaseID: FBgn0033763
• Length: 562
• Species: Drosophila melanogaster
• Sequence 2: NP_002067.1
• Gene: GNS / 2799
• HGNCID: 4422
• Length: 552
• Species: Homo sapiens
• Alignment Length: 578
• Identity: 135/578 - (23%)
• Similarity: 226/578 - (39%)
• Gaps: 160/578 - (27%)

  Fly    25 KPNIIFILADDLGFNDVGFHGSAEIPTPNIDAL-AYSGIILNRYYV-APICTPSRSALMTGKYPI 87
            :||::.:|.||   .|....|..  |.....|| ...|:..:..|| :.:|.|||::::|||||
Human    46 RPNVVLLLTDD---QDEVLGGMT--PLKKTKALIGEMGMTFSSAYVPSALCCPSRASILTGKYP- 104

  Fly    88 HTGMQHTVLYAAEPRGLP------LEEKILPQYLNEL-GYTSHIAGKWHLGHW------KLKYTP 139
            |.  .|.|....|.....      .|....|..|..: ||.:..||| :|..:      .|::.|
Human   105 HN--HHVVNNTLEGNCSSKSWQKIQEPNTFPAILRSMCGYQTFFAGK-YLNEYGAPDAGGLEHVP 166

  Fly   140 LYRGFSSHVGFW---SGHQDYNDHTAVENNQWGLDMRNGTQVAYDLHGHYTTDVITDHSVKVIAN 201
            |  |:|    :|   ..:..|.::|...|   |...::|...:.|    |.|||:.:.|:..: :
Human   167 L--GWS----YWYALEKNSKYYNYTLSIN---GKARKHGENYSVD----YLTDVLANVSLDFL-D 217

  Fly   202 HNATKGPLFLYVAHAACHSSNPYNPLP----------VPDND-----------VIKMSHIP---- 241
            :.:...|.|:.:|..|.||  |:...|          .|.|.           :|:.:..|
Human   218 YKSNFEPFFMMIATPAPHS--PWTAAPQYQKAFQNVFAPRNKNFNIHGTNKHWLIRQAKTPMTNS 280

  Fly   242 ------NYKRRKFAAMVSKMDNSVGQIVDQLRKSNMLENSIIIFSSDNGGPAQGFNLNFASNYPL 300
                  |..|:::..::| :|:.|.::|.:|..:..|.|:.|.::||||.....|:|      |:
Human   281 SIQFLDNAFRKRWQTLLS-VDDLVEKLVKRLEFTGELNNTYIFYTSDNGYHTGQFSL------PI 338

  Fly   301 KGVKNTLWEGGVRAAGLMWSPLLKKSQRVSNQTMHIIDWLPTLLEAAGGQPALSNLSK-QIDGQS 364
            .  |..|:|..::...|:..|.:|.:| .|...:..||..||:|:.||     .:|:| |:||.|
Human   339 D--KRQLYEFDIKVPLLVRGPGIKPNQ-TSKMLVANIDLGPTILDIAG-----YDLNKTQMDGMS 395

  Fly   365 IWRALVQDKASPRLNVLHNIDDIWGSAALSVGDWKLVKGTNYRGSWDGWYGPAGERDPRLYDWQL 429
            :            |.:|....::                     :|         |...|.::|.
Human   396 L------------LPILRGASNL---------------------TW---------RSDVLVEYQG 418

  Fly   430 VGRSRAGKALEALKMLPSRADQQRIRAAATVSCPGQSSQGTSCVATAFSA-----PC-------- 481
            .||:.......:|....|:.....:       |....:...:||.| .||     .|
Human   419 EGRNVTDPTCPSLSPGVSQCFPDCV-------CEDAYNNTYACVRT-MSALWNLQYCEFDDQEVF 475

  Fly   482 --LFHIRDDPCEQYNLAKQY-PEVVNALMTELERFNATAVPPSNKPA--DP--RADPR 532
              ::::..||.:..|:||.. ||::..:...|....:.:.|....|.  ||  |.|||
Human   476 VEVYNLTADPDQITNIAKTIDPELLGKMNYRLMMLQSCSGPTCRTPGVFDPGYRFDPR 533

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8646	NP_610807.3	4-S	26..405	CDD:293753	104/428 (24%)
		DUF4976	<480..510	CDD:419068	8/40 (20%)
GNS	NP_002067.1	G6S	46..495	CDD:293766	124/538 (23%)