Protein Alignment CG8646 and GALNS

DIOPT Version :10

• Sequence 1: NP_610807.3
• Gene: CG8646 / 36394
• FlyBaseID: FBgn0033763
• Length: 562
• Species: Drosophila melanogaster
• Sequence 2: XP_011521284.1
• Gene: GALNS / 2588
• HGNCID: 4122
• Length: 581
• Species: Homo sapiens
• Alignment Length: 540
• Identity: 142/540 - (26%)
• Similarity: 236/540 - (43%)
• Gaps: 128/540 - (23%)

  Fly    35 DLGFNDVGFHGSAEIPTPNIDALAYSGIILNRYYVA-PICTPSRSALMTGKYPIHTGMQHTVLYA 98
            ::|:.|:|.:|.....|||:|.:|..|::...:|.| |:|:|||:||:||:.||..|...|..:|
Human    46 EMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNFYSANPLCSPSRAALLTGRLPIRNGFYTTNAHA 110

  Fly    99 AE---PR----GLPLEEKILPQYLNELGYTSHIAGKWHLGHWKLKYTPLYRGFSSHVGFWSGHQD 156
            ..   |:    |:|..|::||:.|.:.||.|.|.||||||| :.::.||..||....|..:.|..
Human   111 RNAYTPQEIVGGIPDSEQLLPELLKKAGYVSKIVGKWHLGH-RPQFHPLKHGFDEWFGSPNCHFG 174

  Fly   157 YNDHTAVEN--------------NQWGLDMRNG----TQVAYDLHGHYTTDVITDHSVKVIANHN 203
            ..|:.|..|              .::.::::.|    ||:       |..:.:  ..:|..|.|:
Human   175 PYDNKARPNIPVYRDWEMVGRYYEEFPINLKTGEANLTQI-------YLQEAL--DFIKRQARHH 230

  Fly   204 ATKGPLFLYVA----HAACHSSNPYNPLPVPDNDVIKMSHIPNYKRRKFAAMVSKMDNSVGQIVD 264
                |.|||.|    ||..::|.|:               :...:|.::...|.::|:|:|:|::
Human   231 ----PFFLYWAVDATHAPVYASKPF---------------LGTSQRGRYGDAVREIDDSIGKILE 276

  Fly   265 QLRKSNMLENSIIIFSSDNG-----GPAQGFNLNFASNYPLKGVKNTLWEGGVRAAGLMWSPLLK 324
            .|:..::.:|:.:.|:||||     .|.||     .||.|....|.|.:|||:|...|.|.|...
Human   277 LLQDLHVADNTFVFFTSDNGAALISAPEQG-----GSNGPFLCGKQTTFEGGMREPALAWWPGHV 336

  Fly   325 KSQRVSNQTMHIIDWLPTLLEAAGGQPALSNLSKQIDGQSIWRALVQDKASPRLNVLHNIDDIWG 389
            .:.:||:|...|:|...|.|..||..|.   ..:.|||.::...|:|.:...|....:..|.:
Human   337 TAGQVSHQLGSIMDLFTTSLALAGLTPP---SDRAIDGLNLLPTLLQGRLMDRPIFYYRGDTL-- 396

  Fly   390 SAALSVGDWKLVKGTNYRGSWDGWYGPAGERDPRLYDWQLVGRSRAGKALEALKMLPSRADQQRI 454
             .|.::|..|....| :..||:.:                    |.|...
Human   397 -MAATLGQHKAHFWT-WTNSWENF--------------------RQGIDF--------------- 424

  Fly   455 RAAATVSCPGQSSQG--TSCVATAFSAPCLFHIRDDPCEQYNL---AKQYPEVVNALMTELERFN 514
                   ||||:..|  |..:......|.:||:..||.|::.|   :.:|.|.::.:.:.:::..
Human   425 -------CPGQNVSGVTTHNLEDHTKLPLIFHLGRDPGERFPLSFASAEYQEALSRITSVVQQHQ 482

  Fly   515 ATAVPPSNKPADPRADPRFW 534
            ...|     ||.|:.:...|
Human   483 EALV-----PAQPQLNVCNW 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8646	NP_610807.3	4-S	26..405	CDD:293753	117/404 (29%)
		DUF4976	<480..510	CDD:419068	9/32 (28%)
GALNS	XP_011521284.1	GALNS	46..500	CDD:293776	142/540 (26%)