DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8646 and SPBPB10D8.02c

DIOPT Version :9

Sequence 1:	NP_610807.3	Gene:	CG8646 / 36394	FlyBaseID:	FBgn0033763	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_595046.1	Gene:	SPBPB10D8.02c / 2541396	PomBaseID:	SPBPB10D8.02c	Length:	554	Species:	Schizosaccharomyces pombe

Alignment Length:	605	Identity:	135/605 - (22%)
Similarity:	226/605 - (37%)	Gaps:	217/605 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 KPNIIFILADDLGFNDVGFHGSAEIPTPNIDALAYSGIILNRYYVAPICTPSRSALMTGKYPIHT 89
            |||.:.|:|||||::||...|| ||.||||:.||..|:.|..::.|..|:|:||.|::|......
pombe    11 KPNFLVIVADDLGWSDVSPFGS-EIHTPNIERLAKEGVRLTNFHTASACSPTRSMLLSGTDNHIA 74

  Fly    90 G---MQHTV-----LYAAEP--RGLPLEEKI--LPQYLNELGYTSHIAGKWHLGHWKLKYTPLYR 142
            |   |..||     ::..:|  .|. |.:::  ||:.|.|.||.:.::||||||....:| |..|
pombe    75 GLGQMAETVRRFSKVWGGKPGYEGY-LNDRVAALPEILQEAGYYTTMSGKWHLGLTPDRY-PSKR 137

  Fly   143 GF----------SSHVGFWSG----------------HQDYNDHTAVENNQWGLDMRNGTQVAYD 181
            ||          .:|..:..|                :.|..||.:::|
pombe   138 GFKESFALLPGGGNHFAYEPGTRENPAVPFLPPLYTHNHDPVDHKSLKN---------------- 186

  Fly   182 LHGHYTTDVITDHSVKVIANHNATKGPLFLYVAHAACHSSNPYNPLPVPDN-------------D 233
               .|:::...:..:..:.|...::. .|.|:...|     |:.||..|..             |
pombe   187 ---FYSSNYFAEKLIDQLKNREKSQS-FFAYLPFTA-----PHWPLQSPKEYINKYRGRYSEGPD 242

  Fly   234 VIKMSHIPNYK------------------------------------RRKFAAMVSKMDNSVGQI 262
            |::.:.:...|                                    ...:||||..:|.::|::
pombe   243 VLRKNRLQAQKDLGLIPENVIPAPVDGMGTKSWDELTTEEKEFSARTMEVYAAMVELLDLNIGRV 307

  Fly   263 VDQLRKSNMLENSIIIFSSDNGG---------------PAQGF--NLNFASNY------------ 298
            :|.|:....|:|:.:||.||||.               |.:.|  :|....||
pombe   308 IDYLKTIGELDNTFVIFMSDNGAEGSVLEAIPVLSTKPPVKYFDNSLENLGNYNSFIWYGPRWAQ 372

  Fly   299 ----PLKGVKNTLWEGGVRAAGLMWSPLLKKSQRVSNQTMHIIDWLPTLLEAAGGQPALSNLSKQ 359
                |.:..|..:.|||:|...::..|.|.|...:|::.:.::|.|||:||.|    .:.:...:
pombe   373 AATAPSRLSKGFITEGGIRCPAIIRYPPLIKPDIISDEFVTVMDILPTILELA----EVPHPGHK 433

  Fly   360 IDGQSIWRALVQDKASPRLNVLHNIDDIWGSAALSVGDWKLVKGTNYRGSWDGWYGPAGERDPRL 424
            ..|    |.:|..:..|.::  |.:                             :|....:|...
pombe   434 FQG----RDVVIPRGKPWID--HFV-----------------------------HGKPVHKDTDF 463

  Fly   425 YDWQLVGRSRAGKALEALKMLPSRADQQRIRAA--ATVSCPGQSSQGTSCVATAFSAPCLFHIRD 487
            ..|:|.|                   |:.||..  ..:..|.:.      :.|.:.   |:.:..
pombe   464 SGWELFG-------------------QRAIRKGNYKAIYVPKEG------IKTEWE---LYDLSQ 500

  Fly   488 DPCEQYNLAKQYPEVVNALM 507
            |..|..||||.:|:::|.|:
pombe   501 DKGELENLAKVHPDILNELI 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8646	NP_610807.3	AslA	25..459	CDD:225661	123/555 (22%)
		4-S	26..405	CDD:293753	114/498 (23%)
		DUF4976	<462..531	CDD:303608	12/46 (26%)
SPBPB10D8.02c	NP_595046.1	AslA	8..542	CDD:225661	135/605 (22%)
SPBPB10D8.02c	NP_595046.1	PAS_like	10..508	CDD:293749	128/591 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	109	1.000	Domainoid score	I1617
eggNOG	1	0.900	-	-		E1_COG3119
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	111	1.000	Inparanoid score	I1569
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000852
OrthoInspector	1	1.000	-	-		otm47032
orthoMCL	1	0.900	-	-		OOG6_100690
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1868
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.790