DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8646 and Sulf1

DIOPT Version :9

Sequence 1:	NP_610807.3	Gene:	CG8646 / 36394	FlyBaseID:	FBgn0033763	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	XP_008761708.1	Gene:	Sulf1 / 171396	RGDID:	708554	Length:	1117	Species:	Rattus norvegicus

Alignment Length:	531	Identity:	129/531 - (24%)
Similarity:	207/531 - (38%)	Gaps:	134/531 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 WLICLLLPIIDA------------------AEVEKSPAKPNIIFILADDLGFNDVGFHGSAEIPT 51
            |  .|||.::.|                  .:.|:...:||||.:|.||   .||.. ||.::..
  Rat     6 W--ALLLAVLGAELLGGFCSTMRSQRFRGRVQQERKNIRPNIILVLTDD---QDVEL-GSLQVMN 64

  Fly    52 PNIDALAYSG-IILNRYYVAPICTPSRSALMTGKYPIHTGMQHTVLYAAEPRGLPL-----EEKI 110
            .....:.:.| ...|.:...|:|.||||:::|||| :|   .|.|....|....|.     |.:.
  Rat    65 KTRKIMEHGGATFTNAFVTTPMCCPSRSSMLTGKY-VH---NHNVYTNNENCSSPSWQALHEPRT 125

  Fly   111 LPQYLNELGYTSHIAGKWHLGHWKLKYTPLYRGFSSHVGFWSGHQDYNDHTAVENNQWGLDMRNG 175
            ...|||..||.:...|| :|..:...|.|  .|:...:|.....:.|| :|...|   |:..::|
  Rat   126 FAVYLNNTGYRTAFFGK-YLNEYNGSYIP--PGWREWLGLIKNSRFYN-YTVCRN---GIKEKHG 183

  Fly   176 TQVAYDLHGHYTTDVITDHSV------KVIANHNATKGPLFLYVAHAACH---SSNP-------- 223
            ...|.|    |.||:||:.|:      |.:..|.    |:.:.::|||.|   .|.|
  Rat   184 FDYAKD----YFTDLITNESINYFKMSKRMYPHR----PVMMVISHAAPHGPEDSAPQFSKLYPN 240

  Fly   224 --------YNPLPVPDNDVIKMSHIP---------NYKRRKFAAMVSKMDNSVGQIVDQLRKSNM 271
                    ||..|..|...|.....|         |..:||....:..:|:||.::.:.|.::..
  Rat   241 ASQHITPSYNYAPNMDKHWIMQYTGPMLPIHMEFTNVLQRKRLQTLMSVDDSVERLYNMLVETGE 305

  Fly   272 LENSIIIFSSDNGGPAQGFNLNFASNYPLKGVKNTLWEGGVRAAGLMWSPLLKKSQRVSNQTMHI 336
            |.|:.||:::|:|.....|.|       :|| |:..::..:|....:..|.::....|....::
  Rat   306 LGNTYIIYTADHGYHIGQFGL-------VKG-KSMPYDFDIRVPFFIRGPSIEPGSIVPQIVLN- 361

  Fly   337 IDWLPTLLEAAGGQPALSNLSKQIDGQSIWRALVQDKASPRLNVLHNIDDIWGSAALSVGDWKLV 401
            ||..||:|:.||     .:....:||:|:.:.|..:|...|... :....||       .|..||
  Rat   362 IDLAPTILDIAG-----LDTPSDVDGKSVLKLLDLEKPGNRFRT-NKKAKIW-------RDTFLV 413

  Fly   402 KGTNYRGSWDGWYGPAGERDPRLYDWQLVGRSRAGKALEALKMLP--SRADQ--QRIRAAATVSC 462
            :    ||.:                  |..:..:.|.::....||  .|..:  |:.|.......
  Rat   414 E----RGKF------------------LRKKEESSKNIQQSNHLPKYERVKELCQQARYQTACEQ 456

  Fly   463 PGQSSQGTSCV 473
            |||:.|   |:
  Rat   457 PGQNWQ---CI 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8646	NP_610807.3	AslA	25..459	CDD:225661	118/477 (25%)
		4-S	26..405	CDD:293753	109/418 (26%)
		DUF4976	<462..531	CDD:303608	5/12 (42%)
Sulf1	XP_008761708.1	G6S	42..384	CDD:293766	100/378 (26%)
		DUF3740	534..675	CDD:403667
		ALP_like	<767..816	CDD:419962
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3119
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810