DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8646 and Arsb

DIOPT Version :9

Sequence 1:	NP_610807.3	Gene:	CG8646 / 36394	FlyBaseID:	FBgn0033763	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_033842.3	Gene:	Arsb / 11881	MGIID:	88075	Length:	534	Species:	Mus musculus

Alignment Length:	564	Identity:	199/564 - (35%)
Similarity:	303/564 - (53%)	Gaps:	97/564 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LWLICLLLPIIDAAEVEKSPAKPNIIFILADDLGFNDVGFHGSAEIPTPNIDALAYSGIILNRYY 68
            |.|:.|||.::..|....:...|:::|:||||||:||:|||||. |.||::||||..|::|:.||
Mouse    24 LLLLQLLLLLLSPARASGATQPPHVVFVLADDLGWNDLGFHGSV-IRTPHLDALAAGGVVLDNYY 87

  Fly    69 VAPICTPSRSALMTGKYPIHTGMQHTVLYAAEPRGLPLEEKILPQYLNELGYTSHIAGKWHLGHW 133
            |.|:||||||.|:||:|.||.|:||.::...:|..:||:||:|||.|.|.||.:|:.||||||.:
Mouse    88 VQPLCTPSRSQLLTGRYQIHLGLQHYLIMTCQPSCVPLDEKLLPQLLKEAGYATHMVGKWHLGMY 152

  Fly   134 KLKYTPLYRGFSSHVGFWSGHQDYNDHTA------VENNQWGLDMRNGTQVAYDLHGHYTTDVIT 192
            :.:..|..|||.::.|:..|.:||..|.|      :...:..||:|:|.:.|.:.:..|:|::.|
Mouse   153 RKECLPTRRGFDTYFGYLLGSEDYYTHEACAPIESLNGTRCALDLRDGEEPAKEYNNIYSTNIFT 217

  Fly   193 DHSVKVIANHNATKGPLFLYVAHAACHSSNPYNPLPVPDNDVIKMSHIPNYKRRKFAAMVSKMDN 257
            ..:..|||||...| |||||:|..:.|     :||.||:..:.....|.:..||.:|.|||.||.
Mouse   218 KRATTVIANHPPEK-PLFLYLAFQSVH-----DPLQVPEEYMEPYGFIQDKHRRIYAGMVSLMDE 276

  Fly   258 SVGQIVDQLRKSNMLENSIIIFSSDNGGPAQGFNLNFASNYPLKGVKNTLWEGGVRAAGLMWSPL 322
            :||.:...|:...:..|::.|||:||||..:    :..:|:||:|.|.||||||:|..|.:.|||
Mouse   277 AVGNVTKALKSHGLWNNTVFIFSTDNGGQTR----SGGNNWPLRGRKGTLWEGGIRGTGFVASPL 337

  Fly   323 LKKSQRVSNQTMHIIDWLPTLLEAAGGQPALSNLSKQIDGQSIWRALVQDKASPRLNVLHNID-D 386
            ||:....|.:.|||.||||||::.|||.   :|.:|.:||.::|:.:.:...|||:.:||||| |
Mouse   338 LKQKGVKSRELMHITDWLPTLVDLAGGS---TNGTKPLDGFNMWKTISEGHPSPRVELLHNIDQD 399

  Fly   387 IWGS----------------------------AALSVGDWKLVKGTNYRGSWDGWYGPAGERDPR 423
            .:..                            |.:...:|||:.|....|.   |:.|
Mouse   400 FFDGLPCPGKNMTPAKDDSFPLEHSAFNTSIHAGIRYKNWKLLTGHPGCGY---WFPP------- 454

  Fly   424 LYDWQLVGRSRAGKALEALKMLPSRADQQRIRAAATVSCPGQSSQGTSCVATAFSAPCLFHIRDD 488
                                  ||   |..:.....|..|.::.             .||.|..|
Mouse   455 ----------------------PS---QSNVSEIPPVDPPTKTL-------------WLFDINQD 481

  Fly   489 PCEQYNLAKQYPEVVNALMTELERFNATAVPPSNKPADPRADPR 532
            |.|::::::::|.:|..|::.|:.::..:||....|.|||.||:
Mouse   482 PEERHDVSREHPHIVQNLLSRLQYYHEHSVPSHFPPLDPRCDPK 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8646	NP_610807.3	AslA	25..459	CDD:225661	173/468 (37%)
		4-S	26..405	CDD:293753	167/413 (40%)
		DUF4976	<462..531	CDD:303608	17/68 (25%)
Arsb	NP_033842.3	AslA	42..490	CDD:225661	181/509 (36%)
Arsb	NP_033842.3	4-S	46..489	CDD:293753	181/504 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	307	1.000	Domainoid score	I1340
eggNOG	1	0.900	-	-		E1_COG3119
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	352	1.000	Inparanoid score	I2247
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D375140at33208
OrthoFinder	1	1.000	-	-		FOG0000852
OrthoInspector	1	1.000	-	-		mtm8720
orthoMCL	1	0.900	-	-		OOG6_100690
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1868
SonicParanoid	1	1.000	-	-		X499
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.760