DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8646 and arsj

DIOPT Version :9

Sequence 1:	NP_610807.3	Gene:	CG8646 / 36394	FlyBaseID:	FBgn0033763	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	XP_002934299.2	Gene:	arsj / 100494972	XenbaseID:	XB-GENE-951842	Length:	564	Species:	Xenopus tropicalis

Alignment Length:	545	Identity:	209/545 - (38%)
Similarity:	298/545 - (54%)	Gaps:	84/545 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 EKSPAK-----PNIIFILADDLGFNDVGFHGSAEIPTPNIDALAYSGIILNRYYVAPICTPSRSA 79
            |:||.:     |:|:||||||.|:.|:|:||| ||.||.:|.||..|:.|..|||.|||:||||.
Frog    36 EESPQRETGHQPHIVFILADDQGYRDIGYHGS-EIRTPTLDKLASDGVRLENYYVQPICSPSRSQ 99

  Fly    80 LMTGKYPIHTGMQHTVLYAAEPRGLPLEEKILPQYLNELGYTSHIAGKWHLGHWKLKYTPLYRGF 144
            .:||||.||||:||:::..::|..|||:...|||.|.:.||.:|:.||||||.:|.:..|..|||
Frog   100 FITGKYQIHTGLQHSIIRPSQPNCLPLDNMTLPQKLKKAGYQTHMVGKWHLGFYKKECMPTQRGF 164

  Fly   145 SSHVGFWSGHQDYNDHTAVEN-NQWGLDMRNGTQVAYDL-HGHYTTDVITDHSVKVIANHNATKG 207
            .|..|...|..||.:|...:: ...|.|:......|:|. :|.|:|::.|...::::::||..|
Frog   165 DSFFGSLLGSGDYYNHYKCDSPGICGYDLYENNNAAWDQDNGIYSTEMYTQRVLQILSSHNPNK- 228

  Fly   208 PLFLYVAHAACHSSNPYNPLPVPDNDVIKMSHIPNYKRRKFAAMVSKMDNSVGQIVDQLRKSNML 272
            |||||:|:.|.||     ||..|.|.:...:.|.|..||::|||:|.:|::|..:...|:|....
Frog   229 PLFLYIAYQAVHS-----PLQAPGNYLDNYNSILNENRRRYAAMLSCLDDAVNNVTTALKKYGFY 288

  Fly   273 ENSIIIFSSDNGG-PAQGFNLNFASNYPLKGVKNTLWEGGVRAAGLMWSPLLKKSQRVSNQTMHI 336
            :|||||:|||||| |..|.|     |:||:|.|.|.||||:||.|.:.||:||....:..:.:||
Frog   289 DNSIIIYSSDNGGQPMAGGN-----NWPLRGSKGTYWEGGIRAVGFVHSPILKMKGYICKELVHI 348

  Fly   337 IDWLPTLLEAAGGQPALSNLSKQIDGQSIWRALVQDKASPRLNVLHNID---------------D 386
            .||.|||:..|||:   .:...|:||..||..:.:.|.|||..:|||||               .
Frog   349 TDWFPTLVTLAGGE---IDEEIQLDGYDIWETISEGKRSPRQEILHNIDPMYTKARNGSWAAGYG 410

  Fly   387 IWGSA---ALSVGDWKLVKGTNYRGSWDGWYGPAGERDPRLYDWQLVGRSRAGKALEALKMLPSR 448
            ||.:|   |:.|..|||:.|....|.|         ..|:.:       |..|         |:|
Frog   411 IWNTAIQSAIRVNHWKLLTGNPGYGDW---------IPPQSF-------SNVG---------PNR 450

  Fly   449 ADQQRIRAAATVSCPGQSSQGTSCVATAFSAPCLFHIRDDPCEQYNLAKQYPEVVNALMTELERF 513
            ...:|:..|:     |:|             ..||:|..||.|:.:|:.:||::|..|:..|.:|
Frog   451 WHNERVTLAS-----GKS-------------VWLFNITADPYERIDLSDRYPDIVKQLLRRLAQF 497

  Fly   514 NATAVPPSNKPADPRADPRFWNYTW 538
            |.||||....|.|||::|:.....|
Frog   498 NKTAVPVRYPPRDPRSNPKLNGGVW 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8646	NP_610807.3	AslA	25..459	CDD:225661	180/459 (39%)
		4-S	26..405	CDD:293753	171/399 (43%)
		DUF4976	<462..531	CDD:303608	24/68 (35%)
arsj	XP_002934299.2	4-S	47..480	CDD:293753	188/490 (38%)
arsj	XP_002934299.2	DUF4976	<466..>504	CDD:419068	17/37 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	300	1.000	Domainoid score	I1405
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	351	1.000	Inparanoid score	I2217
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D375140at33208
OrthoFinder	1	1.000	-	-		FOG0000852
OrthoInspector	1	1.000	-	-		mtm9380
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X499
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.970