DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ZnT49B and Slc30a9

DIOPT Version :9

Sequence 1:	NP_725207.1	Gene:	ZnT49B / 36393	FlyBaseID:	FBgn0033762	Length:	660	Species:	Drosophila melanogaster
Sequence 2:	NP_001102558.1	Gene:	Slc30a9 / 498358	RGDID:	1593180	Length:	567	Species:	Rattus norvegicus

Alignment Length:	579	Identity:	265/579 - (45%)
Similarity:	355/579 - (61%)	Gaps:	59/579 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 PVLAASAINLRSTSTGVAT----GAVGLGESSG--SVMNPPETVKSAPKNSPSGAVL-------- 177
            |.|||:|...|.:...:..    .||..|.|.|  ::|.........|...|..:||
  Rat     3 PGLAAAAAAHRCSWAALCRLGGGPAVARGRSQGWKNLMTFESFTSMIPSIHPQISVLNQVKLYST 67

  Fly   178 -AEKAGEGIRTSPPAEVTPPAP----------VIPLKRPRFDYRAS------------LERNFVT 219
             .:|.|:|.:| |..:..||..          ..|||:.....|..            .:.||:|
  Rat    68 NVQKGGQGSQT-PRTDKAPPLTQAAENIGAELKAPLKQDPLQVRVKAVLKKREYGSKYTKNNFIT 131

  Fly   220 PNRAISDFLLTAAQLESLPKIKRRSPYEQEPPMTVYWRRDVEAKAVEVWGSKENLLRERLKREVE 284
            ..|||::|.|.::.||.|.||:||||::.....||:.|.||||||:|||||.|.|.||:..|:..
  Rat   132 GVRAINEFCLKSSDLEQLRKIRRRSPHDDTESFTVFLRSDVEAKALEVWGSLEALAREKKLRKEA 196

  Fly   285 RKQYQQIYDSADLFTVKRRLRDYRREMGSRTKVMLDNRKESEKS--------GQVVATAIAINAA 341
            ..:|::     .||..:|.||:|...:|        |.|...::        |:||..||.||..
  Rat   197 EIEYRE-----RLFRNQRILREYGDFLG--------NTKPRSRAISVFLKGPGKVVMVAICINGL 248

  Fly   342 NLLFKAGGWLYSGSHSMFAEVIHSLADLINQLILAFGIYKSSQSPDIDHPYGYMNMRYVSSLISG 406
            |..||...|:|:||.|||:|.||||:|..||.:||.||.||.|:||..||||:.||||:||||||
  Rat   249 NCFFKFLAWIYTGSASMFSEAIHSLSDTCNQGLLALGISKSVQTPDPSHPYGFSNMRYISSLISG 313

  Fly   407 VGIFCVGCGLSIYHGIDGILHPEPITDLFWVYCILMGSLVSEGATLVVAINELKRSAKENNMSFK 471
            ||||.:|.|||.||||.|:|||:|:..|.|.||||.||||||||||:||||||:|||:.|..||.
  Rat   314 VGIFMMGAGLSWYHGIMGLLHPQPMESLLWAYCILAGSLVSEGATLLVAINELRRSAQANGTSFY 378

  Fly   472 DYVISGKDPCVNVVLCEDAAAVTGVMVAAACMGLSSYTGSPIFDAAGSLVIGALLGAVASFIIYT 536
            .||:..:||..||:|.||.|||.|||:||.||||:|.||:|::|:.|||.:|.|||.|::|:|.|
  Rat   379 KYVMESRDPSTNVILLEDTAAVLGVMIAATCMGLTSITGNPLYDSLGSLGVGTLLGVVSAFLIST 443

  Fly   537 NANALVGISIASERLEKINSALEADVMIRAIYDVKGIDIGNARVRYKAELDFDGRELTRSYLDKQ 601
            |..||:|.||..|:::::...||:|..:|||:|||..|:|..:||:|||:|||||.:|||||:||
  Rat   444 NIEALLGRSIQPEQVQRLTELLESDPSVRAIHDVKATDLGLGKVRFKAEVDFDGRVVTRSYLEKQ 508

  Fly   602 DLAKLLTTVRGFQKVEDLESFLLDQGENIVDLMGGEIDRIEMNLRTQFPEIRHVDLEIL 660
            |..:::..:...:..|.||:|:|..||||:|.:|.|:||:|..|:.:.||:||||||||
  Rat   509 DFDQMMQEIEEVKTPEQLEAFMLKHGENIIDTLGAEVDRLEKELKKRNPEVRHVDLEIL 567

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZnT49B	NP_725207.1	Cation_efflux	343..542	CDD:279834	124/198 (63%)
Slc30a9	NP_001102558.1	rad14	123..>208	CDD:273164	39/89 (44%)
Slc30a9	NP_001102558.1	Cation_efflux	250..449	CDD:279834	124/198 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335154
Domainoid	1	1.000	267	1.000	Domainoid score	I1809
eggNOG	1	0.900	-	-		E1_COG0053
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4627
Inparanoid	1	1.050	463	1.000	Inparanoid score	I1492
OMA	1	1.010	-	-		QHG48079
OrthoDB	1	1.010	-	-		D455459at33208
OrthoFinder	1	1.000	-	-		FOG0006611
OrthoInspector	1	1.000	-	-		oto98060
orthoMCL	1	0.900	-	-		OOG6_104141
Panther	1	1.100	-	-	LDO	PTHR13414
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4848
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.810