DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZnT49B and slc30a9

DIOPT Version :9

Sequence 1:	NP_725207.1	Gene:	ZnT49B / 36393	FlyBaseID:	FBgn0033762	Length:	660	Species:	Drosophila melanogaster
Sequence 2:	NP_001354928.1	Gene:	slc30a9 / 100216137	XenbaseID:	XB-GENE-976698	Length:	563	Species:	Xenopus tropicalis

Alignment Length:	501	Identity:	255/501 - (50%)
Similarity:	353/501 - (70%)	Gaps:	16/501 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   168 PKNSPSGAVLAEKAGEGIRTSPPAEVT--PPAPV-----IPLKRPRFDYRASLERNFVTPNRAIS 225
            || .||.|...||:..|:.:|...:.:  ||.|:     ..||:..:..: .::.||:|..||::
Frog    71 PK-GPSAASSQEKSTAGLDSSKSEQKSTFPPDPIQVKVKAVLKKREYGTK-YMKNNFITGVRALN 133

  Fly   226 DFLLTAAQLESLPKIKRRSPYEQEPPMTVYWRRDVEAKAVEVWGSKENLLRERLKREVERKQYQQ 290
            :|.|..:.||||.||:||||::.....|||.|.||||||.|||||.|.:.|||..|:.|...|::
Frog   134 EFCLKPSDLESLRKIRRRSPHDDTEAFTVYLRSDVEAKAYEVWGSPEAIFRERKMRKEEEIAYRE 198

  Fly   291 IYDSADLFTVKRRLRDYRREMGSRTKVMLDNRKESEKS-GQVVATAIAINAANLLFKAGGWLYSG 354
                 :||..::.|::|:..:|: ||..|.......|. |:||..||.||..|..||...|:|:|
Frog   199 -----NLFKNQKLLKEYKDFLGN-TKPRLSTSNMFMKGPGKVVMVAICINGLNFFFKLLAWVYTG 257

  Fly   355 SHSMFAEVIHSLADLINQLILAFGIYKSSQSPDIDHPYGYMNMRYVSSLISGVGIFCVGCGLSIY 419
            |.|||:|.:|||||.:||.:||.||.:|.::||..||||:.||||::|||||||||.:|.|||.|
Frog   258 SASMFSEALHSLADTLNQALLALGISQSVRTPDPGHPYGFTNMRYIASLISGVGIFMMGAGLSWY 322

  Fly   420 HGIDGILHPEPITDLFWVYCILMGSLVSEGATLVVAINELKRSAKENNMSFKDYVISGKDPCVNV 484
            |||.|:|||:||..|.|.||||.||||||||||:|||||:::|||...:||.:||:..:||..||
Frog   323 HGIMGLLHPQPIESLLWAYCILAGSLVSEGATLLVAINEIRKSAKTKGLSFYEYVMQSRDPSTNV 387

  Fly   485 VLCEDAAAVTGVMVAAACMGLSSYTGSPIFDAAGSLVIGALLGAVASFIIYTNANALVGISIASE 549
            ||.||||||.|:::||:||||:|.||:|::|:.|||.:|.|||||::|:||||..||:|.||..|
Frog   388 VLMEDAAAVLGLVMAASCMGLTSLTGNPLYDSLGSLGVGTLLGAVSAFLIYTNTEALIGRSIQPE 452

  Fly   550 RLEKINSALEADVMIRAIYDVKGIDIGNARVRYKAELDFDGRELTRSYLDKQDLAKLLTTVRGFQ 614
            :::::...||:|..:|||:|||..|:|.::||:|||:|||||.:|||||:|||:.::|..:|..:
Frog   453 QVQRLTELLESDPAVRAIHDVKATDMGMSKVRFKAEVDFDGRVVTRSYLEKQDIDQVLNEIRQVK 517

  Fly   615 KVEDLESFLLDQGENIVDLMGGEIDRIEMNLRTQFPEIRHVDLEIL 660
            ..||||:|:|..||||:|.:|.|:||:|..|:.:.||:||||||||
Frog   518 TAEDLEAFMLKHGENIIDTLGAEVDRLEKELKQRNPEVRHVDLEIL 563

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZnT49B	NP_725207.1	Cation_efflux	343..542	CDD:279834	122/198 (62%)
slc30a9	NP_001354928.1	XPA_C	119..>209	CDD:391673	42/95 (44%)
slc30a9	NP_001354928.1	FieF	233..559	CDD:357667	186/325 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	270	1.000	Domainoid score	I1796
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	482	1.000	Inparanoid score	I1426
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D455459at33208
OrthoFinder	1	1.000	-	-		FOG0006611
OrthoInspector	1	1.000	-	-		oto104749
Panther	1	1.100	-	-	LDO	PTHR13414
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2191
SonicParanoid	1	1.000	-	-		X4848
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	9.190