DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8778 and CDY2A

DIOPT Version :9

Sequence 1:	NP_610805.1	Gene:	CG8778 / 36392	FlyBaseID:	FBgn0033761	Length:	299	Species:	Drosophila melanogaster
Sequence 2:	NP_004816.1	Gene:	CDY2A / 9426	HGNCID:	1810	Length:	541	Species:	Homo sapiens

Alignment Length:	311	Identity:	63/311 - (20%)
Similarity:	118/311 - (37%)	Gaps:	36/311 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSMLIKRASGLARQL-----ARPLVAS-----RNLASAAPYGDGTEVLVERLDGARQGISVIGLN 55
            |...:.|..|..|.:     .:|.:..     |...||..|.|   ::|::.||..|   ::...
Human   244 MHTSVPRVKGGQRNITDDSRGQPFIKKMHFTIRLTESAITYRD---IVVKKEDGFTQ---IVLST 302

  Fly    56 RPAAKNSFS----RGMVETFNDVLEDIKKDNGSRVVVLRSLSPGIFCAGAD----LKERKGMTPE 112
            |...||:.:    :.||...|....|..|      :||.|.:..:||.|.|    ::..:.....
Human   303 RSTEKNALNTEVIKEMVNALNSAAADDSK------LVLFSAAGSVFCCGLDFGYFVRHLRNDRNT 361

  Fly   113 EATEFVKELRGLLIAIEQLPMPVIAAVDGAALGGGLEMALACDIRTAASDTKMGLVETRLAIIPG 177
            .:.|.|..::..:....|...|::.:|:|.|:|.|..:...||:..|..........|.....|.
Human   362 ASLEMVDTIKNFVNTFIQFKKPIVVSVNGPAIGLGASILPLCDLVWANEKAWFQTPYTTFGQSPD 426

  Fly   178 AGGTQRLPRILSPALAKELIFTARVFNGAEAKDLGLVNHV-VKQNETQDAAYQQALKLAEEILPN 241
            ...:...|:::..|.|.|::...|.....||...|||:.| :....||:...|     .:|:...
Human   427 GCSSITFPKMMGKASANEMLIAGRKLTAREACAKGLVSQVFLTGTFTQEVMIQ-----IKELASY 486

  Fly   242 GPVGVRMAKLAIDKGMQVDLATGYSIEEICYSQVIPTKDRLEGLAAFAEKR 292
            ..:.:...|..:...::::|......|.....::..:...:|.:..:.|.:
Human   487 NAIVLEECKALVRCNIKLELEQANERECEVLRKIWSSAQGIESMLKYVENK 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8778	NP_610805.1	crotonase-like	48..299	CDD:304874	49/254 (19%)
CDY2A	NP_004816.1	CHROMO	5..58	CDD:214605
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	72..104
		crotonase-like	287..483	CDD:119339	47/209 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148284
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840