DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8778 and CDYL

DIOPT Version :9

Sequence 1:	NP_610805.1	Gene:	CG8778 / 36392	FlyBaseID:	FBgn0033761	Length:	299	Species:	Drosophila melanogaster
Sequence 2:	NP_001355054.1	Gene:	CDYL / 9425	HGNCID:	1811	Length:	598	Species:	Homo sapiens

Alignment Length:	247	Identity:	58/247 - (23%)
Similarity:	102/247 - (41%)	Gaps:	24/247 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 RNLASAAPYGDGTEVLVERLDGARQGISVIGLNRPAAKNSFSRGMVETFNDVLEDIKKDNGSRVV 87
            |...||..|.|   ::|.:.||...   ::...:.:..||.:..::......|.....|: |::|
Human   333 RQTESAYRYRD---IVVRKQDGFTH---ILLSTKSSENNSLNPEVMREVQSALSTAAADD-SKLV 390

  Fly    88 VLRSLSPGIFCAGADL--------KERKGMTPEEATEFVKELRGLLIAIEQLPMPVIAAVDGAAL 144
            :|.::. .:||.|.|.        .:||    .|:|:..:.:|..:....|...|:|.||:|.|:
Human   391 LLSAVG-SVFCCGLDFIYFIRRLTDDRK----RESTKMAEAIRNFVNTFIQFKKPIIVAVNGPAI 450

  Fly   145 GGGLEMALACDIRTAASDTKMGLVETRLAIIPGAGGTQRLPRILSPALAKELIFTARVFNGAEAK 209
            |.|..:...||:..|..........|.....|....|...|:|:..|.|.|::.:.|.....||.
Human   451 GLGASILPLCDVVWANEKAWFQTPYTTFGQSPDGCSTVMFPKIMGGASANEMLLSGRKLTAQEAC 515

  Fly   210 DLGLVNHVVKQNETQDAAYQQALKLAEEILPNGPVGVRMAKLAIDKGMQVDL 261
            ..|||:.|.    ......|:.:...:|:....||.:..:|..:...|:::|
Human   516 GKGLVSQVF----WPGTFTQEVMVRIKELASCNPVVLEESKALVRCNMKMEL 563

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8778	NP_610805.1	crotonase-like	48..299	CDD:304874	50/222 (23%)
CDYL	NP_001355054.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..76
		Interaction with EZH2. /evidence=ECO:0000269\|PubMed:22009739	61..309
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	112..149
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	204..226
		Acetyl-CoA-binding domain. /evidence=ECO:0000255	362..594		50/212 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148286
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1024
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740