DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8778 and Eci2

DIOPT Version :9

Sequence 1:	NP_610805.1	Gene:	CG8778 / 36392	FlyBaseID:	FBgn0033761	Length:	299	Species:	Drosophila melanogaster
Sequence 2:	NP_001103801.1	Gene:	Eci2 / 23986	MGIID:	1346064	Length:	391	Species:	Mus musculus

Alignment Length:	275	Identity:	68/275 - (24%)
Similarity:	117/275 - (42%)	Gaps:	29/275 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 ARQLARPLVASRNLASAAP----------YGDGTEVLVERLDGARQGISVIGLNRPAAKNSFSRG 66
            |||....||:|.:.:|.||          ..:..::||...|    ||:.|..|||..||:.|
Mouse   105 ARQNYVDLVSSLSSSSEAPSQGKRGADEKARESKDILVTSED----GITKITFNRPTKKNAIS-- 163

  Fly    67 MVETFNDVLEDIKKDNGSRVVVLRSLSPG-IFCAGADL---KERKGMTPEEATEFVKELRGLLIA 127
             .:.:.|::..:|..:....|:......| .:|:|.||   ....|...|.|:.....||..:.:
Mouse   164 -FQMYRDIILALKNASTDNTVMAVFTGTGDYYCSGNDLTNFTSATGGIEEAASNGAVLLRDFVNS 227

  Fly   128 IEQLPMPVIAAVDGAALGGGLEMALACDIRTAASDTKMGLVETRLAIIPGAGGTQRLPRILSPAL 192
            ....|.|::|.|:|.|:|..:.:....|...|:.........::|...|.|..:...|:::..|.
Mouse   228 FIDFPKPLVAVVNGPAVGISVTLLGLFDAVFASDRATFHTPFSQLGQSPEACSSYTFPKMMGSAK 292

  Fly   193 AKELIFTARVFNGAEAKDLGLVNHVVKQNETQDAAYQQALKLAEEILPNGPVGVRMAKLAIDKGM 257
            |.|::...:.....||...|||..|..::..:...:.: ||...::.||   .:|::|..|.|..
Mouse   293 AAEMLLFGKKLTAREAWAQGLVTEVFPESTFETEVWTR-LKTYAKLPPN---AMRISKELIRKNE 353

  Fly   258 QVDLATGYSIE-EIC 271
            :..|   |::. |.|
Mouse   354 KEKL---YAVNAEEC 365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8778	NP_610805.1	crotonase-like	48..299	CDD:304874	56/229 (24%)
Eci2	NP_001103801.1	ACBP	38..113	CDD:279259	3/7 (43%)
		Acyl-CoA binding. /evidence=ECO:0000250	64..68
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	116..136		3/19 (16%)
		crotonase-like	139..389	CDD:304874	59/241 (24%)
		ECH-like	149..319		42/172 (24%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q05871	196..200		1/3 (33%)
		Microbody targeting signal. /evidence=ECO:0000255	389..391
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1024
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810