DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8778 and EHHADH

DIOPT Version :9

Sequence 1:	NP_610805.1	Gene:	CG8778 / 36392	FlyBaseID:	FBgn0033761	Length:	299	Species:	Drosophila melanogaster
Sequence 2:	NP_001957.2	Gene:	EHHADH / 1962	HGNCID:	3247	Length:	723	Species:	Homo sapiens

Alignment Length:	287	Identity:	76/287 - (26%)
Similarity:	128/287 - (44%)	Gaps:	50/287 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 RLDGARQGISVIGLNRPAAKNSFSRGMVETFNDVLEDIKKDNGSRVVVLRSLSPGIFCAGADLKE 105
            ||..|   :::|.|..|.. |:.|..::....:.|:....|:..:.:|:.. :.|.|.||||:
Human     6 RLHNA---LALIRLRNPPV-NAISTTLLRDIKEGLQKAVIDHTIKAIVICG-AEGKFSAGADI-- 63

  Fly   106 RKGMTPEEATEFVKELRGLLIAIEQLPMPVIAAVDGAALGGGLEMALACDIRTAASDTKMGLVET 170
             :|.:....  |...|..::..|::...||:||:.|.|.|||||:||.|..|.|.::.::||.|.
Human    64 -RGFSAPRT--FGLTLGHVVDEIQRNEKPVVAAIQGMAFGGGLELALGCHYRIAHAEAQVGLPEV 125

  Fly   171 RLAIIPGAGGTQRLPRILSPALAKELIFTARVFNGAEAKDLGLVNHVVKQNETQDAAYQQALKLA 235
            .|.::|||.|||.|||:.....|.:||.:.|.....||..||:::.||..:..     ::|::.|
Human   126 TLGLLPGARGTQLLPRLTGVPAALDLITSGRRILADEALKLGILDKVVNSDPV-----EEAIRFA 185

  Fly   236 EEI-----------------LPN-----------------GPVGVRMAKLAIDKGMQVDLATGYS 266
            :.:                 |||                 |.:.......|:...:|.....|..
Human   186 QRVSDQPLESRRLCNKPIQSLPNMDSIFSEALLKMRRQHPGCLAQEACVRAVQAAVQYPYEVGIK 250

  Fly   267 IEEICYSQVIPT-KDRLEGLAAFAEKR 292
            .||..:..::.: :.|....|.|||::
Human   251 KEEELFLYLLQSGQARALQYAFFAERK 277

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8778	NP_610805.1	crotonase-like	48..299	CDD:304874	73/280 (26%)
EHHADH	NP_001957.2	Enoyl-CoA hydratase / isomerase	1..282		76/287 (26%)
		fadJ	20..705	CDD:333311	70/270 (26%)
		3-hydroxyacyl-CoA dehydrogenase	283..572
		Microbody targeting signal	721..723
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1024
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810