DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8778 and ECI2

DIOPT Version :9

Sequence 1:	NP_610805.1	Gene:	CG8778 / 36392	FlyBaseID:	FBgn0033761	Length:	299	Species:	Drosophila melanogaster
Sequence 2:	NP_996667.2	Gene:	ECI2 / 10455	HGNCID:	14601	Length:	394	Species:	Homo sapiens

Alignment Length:	288	Identity:	70/288 - (24%)
Similarity:	117/288 - (40%)	Gaps:	32/288 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 ARQLARPLVA--SRNLASAAPYGDGT-------EVLVERLDGARQGISVIGLNRPAAKNSFSRGM 67
            |||....||:  |.:|.|::....||       |.||..   :..||:.|..|||..||:.:..|
Human   107 ARQNYVDLVSSLSPSLESSSQVEPGTDRKSTGFETLVVT---SEDGITKIMFNRPKKKNAINTEM 168

  Fly    68 VETFNDVLEDIKKDNGSRVVVLRSLSPGIFCAGADLKERKGMTPEEATEFVKE----LRGLLIAI 128
            .......|:...||:.  ::.:.:.:...:.:|.||.....:.|....|..|.    ||..:...
Human   169 YHEIMRALKAASKDDS--IITVLTGNGDYYSSGNDLTNFTDIPPGGVEEKAKNNAVLLREFVGCF 231

  Fly   129 EQLPMPVIAAVDGAALGGGLEMALACDIRTAASDTKMGLVETRLAIIPGAGGTQRLPRILSPALA 193
            ...|.|:||.|:|.|:|..:.:....|...|:.........:.|...|....:...|:|:|||.|
Human   232 IDFPKPLIAVVNGPAVGISVTLLGLFDAVYASDRATFHTPFSHLGQSPEGCSSYTFPKIMSPAKA 296

  Fly   194 KELIFTARVFNGAEAKDLGLVNHVVKQNETQDAAYQQALKLAEEILPNGPVGVRMAKLAIDK--- 255
            .|::...:.....||...|||..|...:..|...:.: ||...::.||   .:|::|..|.|
Human   297 TEMLIFGKKLTAGEACAQGLVTEVFPDSTFQKEVWTR-LKAFAKLPPN---ALRISKEVIRKRER 357

  Fly   256 -------GMQVDLATGYSIEEICYSQVI 276
                   ..:.::..|..:.:.|.:.|:
Human   358 EKLHAVNAEECNVLQGRWLSDECTNAVV 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8778	NP_610805.1	crotonase-like	48..299	CDD:304874	57/243 (23%)
ECI2	NP_996667.2	ACBP	40..113	CDD:279259	3/5 (60%)
		Acyl-CoA binding. /evidence=ECO:0000250	66..70
		crotonase-like	142..335	CDD:119339	48/198 (24%)
		ECH-like	151..322		43/172 (25%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q05871	198..202		1/3 (33%)
		Microbody targeting signal. /evidence=ECO:0000255	392..394
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1024
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810