DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8785 and Slc38a4

DIOPT Version :9

Sequence 1:	NP_610804.1	Gene:	CG8785 / 36391	FlyBaseID:	FBgn0033760	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_001344987.1	Gene:	Slc38a4 / 69354	MGIID:	1916604	Length:	547	Species:	Mus musculus

Alignment Length:	571	Identity:	119/571 - (20%)
Similarity:	212/571 - (37%)	Gaps:	160/571 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 DNKGFTPDGQ----ESLPSAPT-VENPPPYTNAIN------DFNSKANLT-----EKELSLTDDP 51
            :|....|||.    :|:..:.| :||..  .:|:|      |..|:..||     :|:|:...|.
Mouse     7 NNVSIEPDGDSCSGDSIQDSYTGMENSD--KDAMNSQFANEDAESQKFLTNGFLGKKKLADYADE 69

  Fly    52 YHPFEHRDPNGASAGGALAHLLKSSLGTGILAMPMAFHNAGLAFGMAMTLIVGFLCTHCVHILVK 116
            :|      |...|.|.:..:|..:.:|:|||.:..|..|.|:...:.|.|.|..|..:.||:|:|
Mouse    70 HH------PGMTSFGMSSFNLSNAIMGSGILGLSYAMANTGIILFIIMLLTVAILSLYSVHLLLK 128

  Fly   117 TSHDICRDAKVSALGFAETAEKVFEYGPKGMRPYSNFAKQFVDIGLMATYYAAACVYIVFIATSF 181
            |:.:      ..:|.:.:..||.|.: |..:..:.:...|  :||.|::       |:..|....
Mouse   129 TAKE------GGSLIYEKLGEKAFGW-PGKIGAFISITMQ--NIGAMSS-------YLFIIKYEL 177

  Fly   182 HDVI-----------NYDLKINWDVRIYIALTVIPCLLIGQIRDLKWLVPFSMMANIFIVVTFAI 235
            .:||           .:.|..|:.|.......::|..|:..:..|.:...||:...:|.|   ::
Mouse   178 PEVIRAFMGLEENTGEWYLNGNYLVLFVSVGIILPLSLLKNLGYLGYTSGFSLSCMVFFV---SV 239

  Fly   236 TLYYMFDEP------------LVYS---------------------------------DKPLIAK 255
            .:|..|..|            |.::                                 |:..:|.
Mouse   240 VIYKKFQIPCPLPALDHNNGNLTFNNTLPIHMISLPNDSESSGVNFMMDYAHHNPAGLDEKQVAG 304

  Fly   256 AAHI--------------PLFFA----------TVIFAMEGIGVVMPV-----ENSMRKPQHFLG 291
            ..|.              |.:|.          .:.||......|:|:     :.|.||.|
Mouse   305 PLHSNGVEYEAQGAEKCQPKYFVFNSRTAYAIPILAFAFVCHPEVLPIYSELKDRSRRKMQ---- 365

  Fly   292 CPGVLNIAMVTVVSLYAIIGFFGYVRFGDQVRGSITLNLPEGAWLGDTAKLLMAVAILFTFGLQ- 355
              .|.||::..::.:|.:...|||:.|...|...: |:.....:..|||.|::.:|:|....|.
Mouse   366 --TVSNISISGMLVMYLLAALFGYLSFYGDVEDEL-LHAYSKVYTFDTALLMVRLAVLVAVTLTV 427

  Fly   356 ----FYVPNEILWRKISHK-FSPEKH-NITQILLRSGIILLSGGVAAAIPNLEPFISLVGAVFFS 414
                |.:...::......| ||..|| .|..|     ||.|:..:...:|.::.....:||...:
Mouse   428 PIVLFPIRTSVITLLFPRKPFSWLKHFGIAAI-----IIALNNILVILVPTIKYIFGFIGASSAT 487

  Fly   415 LLGIFVPSFVETVYL---------WPDRLGVCKWKLVKNIF-LGVFSILAL 455
            :|...:|:   ..||         .|.::|...:.:...|| :|..:::.|
Mouse   488 MLIFILPA---AFYLKLVKKEPLRSPQKIGALVFLVTGIIFMMGSMALIIL 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8785	NP_610804.1	SdaC	60..457	CDD:223884	101/498 (20%)
CG8785	NP_610804.1	SLC5-6-like_sbd	62..463	CDD:294310	100/496 (20%)
Slc38a4	NP_001344987.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..34		8/26 (31%)
Slc38a4	NP_001344987.1	SLC5-6-like_sbd	75..535	CDD:382020	99/493 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0814
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54358
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910