DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8785 and CG4991

DIOPT Version :9

Sequence 1:	NP_610804.1	Gene:	CG8785 / 36391	FlyBaseID:	FBgn0033760	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_001259638.1	Gene:	CG4991 / 32695	FlyBaseID:	FBgn0030817	Length:	496	Species:	Drosophila melanogaster

Alignment Length:	461	Identity:	151/461 - (32%)
Similarity:	241/461 - (52%)	Gaps:	32/461 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 ENPPPYTNAINDFNSKANLTEKELSLTDDPYHPFEHRDP-----NGASAGGALAHLLKSSLGTGI 81
            :||..:|.         |:|||..    ||    |:.||     :..|...|..||.|.|:|.|:
  Fly    55 KNPERFTK---------NVTEKGA----DP----ENGDPVRRRGHETSELEAATHLFKGSVGAGL 102

  Fly    82 LAMPMAFHNAGLAFGMAMTLIVGFLCTHCVHILVKTS-HDICRDAKVSALGFAETAEKVFEYGPK 145
            .||...|.|.|||....:..|:..:|.||..:|::.| ..:.|...|..|.:.||.||.||:||:
  Fly   103 FAMGDCFKNGGLAGATILLPIIAVMCVHCERMLIRGSVLAVERTPGVDFLDYPETVEKCFEHGPR 167

  Fly   146 GMRPYSNFAKQFVDIGLMATYYAAACVYIVFIATSFHDVINYDLKINWDVRIYIALTVIPCLLIG 210
            .:|..|...|..|::.|..|.:....:|.|||..:.|.|:..: .|...:.:.:.:|::|.::..
  Fly   168 PLRKMSRVMKLIVEMFLCVTQFGFCAIYFVFITENLHQVLQQN-GIVISMSMVMLITLLPAMIPS 231

  Fly   211 QIRDLKWLVPFSMMANIFIVVTFAITLYYMF-DEPL-VYSDKPLIAKAAHIPLFFATVIFAMEGI 273
            .:.:||::.|.|:.||:.::.....||...| |.|: ...|:.|....|.:.|||.|.:|:.|||
  Fly   232 LMTNLKYISPVSLFANVALLFGLIATLTIAFSDGPMPSVGDRHLFTGGAQLALFFGTALFSYEGI 296

  Fly   274 GVVMPVENSMRKPQHFLGCPGVLNIAMVTVVSLYAIIGFFGYVRFGDQVRGSITLNLPEGAWLGD 338
            .:::|:.||||:|:.|....||||..|....:|:...||..|||:|::|.|||||||........
  Fly   297 ALILPLRNSMRRPEKFSTRFGVLNSTMFFTTALFIFTGFVSYVRWGEEVAGSITLNLVVEEVFSQ 361

  Fly   339 TAKLLMAVAILFTFGLQFYVPNEILWRKISHKFS-PEKHNIT-QILLRSGIILLSGGVAAAIPNL 401
            ..|::.|:.:...:.:||:|..:|||..:....: .:|:.|| |:.||..:::::.|||..:|.|
  Fly   362 VVKVIAALGVFLGYPIQFFVMIKILWPPLKRSNNCTQKYPITSQVCLRFFMVMMTFGVALVVPKL 426

  Fly   402 EPFISLVGAVFFSLLGIFVPSFVE--TVYLWPDRLGVCKWKLVKNIFLGVFSILALVAGAVASIN 464
            ..||||:||:..:.|...:|..::  |....|..|||  |..:|||.:...::|.:|.|...||.
  Fly   427 NLFISLIGALCSTCLAFVIPVLIDFVTRAQVPKALGV--WSYIKNILILTVAVLGIVTGTYQSIV 489

  Fly   465 EIIEMY 470
            ||::.:
  Fly   490 EIVKEF 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8785	NP_610804.1	SdaC	60..457	CDD:223884	134/408 (33%)
CG8785	NP_610804.1	SLC5-6-like_sbd	62..463	CDD:294310	135/407 (33%)
CG4991	NP_001259638.1	SLC5-6-like_sbd	82..489	CDD:294310	136/409 (33%)
CG4991	NP_001259638.1	SdaC	84..488	CDD:223884	135/406 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	157	1.000	Domainoid score	I1306
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1622
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D284074at33208
OrthoFinder	1	1.000	-	-		FOG0000138
OrthoInspector	1	1.000	-	-		mtm1178
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR22950
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X121
	8	8.070