DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8785 and SLC36A3

DIOPT Version :9

Sequence 1:	NP_610804.1	Gene:	CG8785 / 36391	FlyBaseID:	FBgn0033760	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_001138489.1	Gene:	SLC36A3 / 285641	HGNCID:	19659	Length:	511	Species:	Homo sapiens

Alignment Length:	499	Identity:	142/499 - (28%)
Similarity:	231/499 - (46%)	Gaps:	75/499 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 DFNSKANL--------TEKELSLTDDPYHPFEHRDPNGASAGGALAHLLKSSLGTGILAMPMAFH 89
            |:||:.|.        :|...|:|.:..||   ....|.|....|.||||.::|||:|.:|:|..
Human     7 DYNSELNSLDNGPQSPSESSSSITSENVHP---AGEAGLSMMQTLIHLLKCNIGTGLLGLPLAIK 68

  Fly    90 NAGLAFGMAMTLIVGFLCTHCVHILVKTSHDICRDAKVSALGFAETAEKVFEYGPK-GMRPYS-- 151
            ||||..|....|.:|.|..||:.||:..:..:.:..:.:.:.:.|......|..|. .:|.::
Human    69 NAGLLVGPVSLLAIGVLTVHCMVILLNCAQHLSQRLQKTFVNYGEATMYGLETCPNTWLRAHAVW 133

  Fly   152 ---NFA------------------------------------KQFVDIGLMATYYAAACVYIVFI 177
               |.|                                    :..|...|:.|......||.:|:
Human   134 GRWNLALSPRLECSGKISAHCNPHLQGSSNSPAQASRVAGIYRYTVSFLLVITQLGFCSVYFMFM 198

  Fly   178 ATSFHDVIN--------------YDLKINWDVRIYIALTVIPCL-LIGQIRDLKWLVPFSMMANI 227
            |.:...::.              ..|....|:|.|: |.::|.| |:..|::||.|..||.:|||
Human   199 ADNLQQMVEKAHVTSNICQPREILTLTPILDIRFYM-LIILPFLILLVFIQNLKVLSVFSTLANI 262

  Fly   228 FIVVTFAITLYYMFDEPLVYSDKPLIAKAAHIPLFFATVIFAMEGIGVVMPVENSMRKPQHFLGC 292
            ..:.:.|:...|:.:.....|:.||:|......|||.|.||..||:|:|:|::|.|:.||.|
Human   263 TTLGSMALIFEYIMEGIPYPSNLPLMANWKTFLLFFGTAIFTFEGVGMVLPLKNQMKHPQQF--- 324

  Fly   293 PGVLNIAMVTVVSLYAIIGFFGYVRFGDQVRGSITLNLPEGAWLGDTAKLLMAVAILFTFGLQFY 357
            ..||.:.|..|:.||.::|..||::||...:.||||||| ..||..:.||:.::.|.||:.|||:
Human   325 SFVLYLGMSIVIILYILLGTLGYMKFGSDTQASITLNLP-NCWLYQSVKLMYSIGIFFTYALQFH 388

  Fly   358 VPNEILWRKISHKFSPEKHNITQILLRSGIILLSGGVAAAIPNLEPFISLVGAVFFSLLGIFVPS 422
            ||.||:......:.|........:.:||.::.|:...|..||.|:..|||||:|..|.|.:.:|:
Human   389 VPAEIIIPFAISQVSESWALFVDLSVRSALVCLTCVSAILIPRLDLVISLVGSVSSSALALIIPA 453

  Fly   423 FVETVYLWPDRLGVCKWKLVKNIFLGVFSILALVAGAVASINEI 466
            .:|.|..:.:.:...  .:.|:|.:.:..:|..:.|...::.|:
Human   454 LLEIVIFYSEDMSCV--TIAKDIMISIVGLLGCIFGTYQALYEL 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8785	NP_610804.1	SdaC	60..457	CDD:223884	131/453 (29%)
CG8785	NP_610804.1	SLC5-6-like_sbd	62..463	CDD:294310	132/457 (29%)
SLC36A3	NP_001138489.1	SLC5-6-like_sbd	41..492	CDD:320982	132/457 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0814
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54358
OrthoDB	1	1.010	-	-		D284074at33208
OrthoFinder	1	1.000	-	-		FOG0000138
OrthoInspector	1	1.000	-	-		mtm8520
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22950
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X121
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.930