DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8785 and Slc36a4

DIOPT Version :9

Sequence 1:	NP_610804.1	Gene:	CG8785 / 36391	FlyBaseID:	FBgn0033760	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_758493.2	Gene:	Slc36a4 / 234967	MGIID:	2442595	Length:	500	Species:	Mus musculus

Alignment Length:	479	Identity:	154/479 - (32%)
Similarity:	243/479 - (50%)	Gaps:	38/479 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 VENPPPYTNA-------------INDFN-SKANLTEKELSLTDDPYHPFEHRDPNGASAGGALAH 71
            :|.|.|...|             ||:.| ..::..|:|.:|.....| ::....:|.|....|.|
Mouse     1 MEAPAPAETAGCEELDMDVMRPLINEQNFDGSSDEEQEQTLVPIQKH-YQLDGQHGISFLQTLVH 64

  Fly    72 LLKSSLGTGILAMPMAFHNAGLAFGMAMTLIVGFLCTHCVHILVKTSHDICRDAKVSALGFAETA 136
            |||.::|||:|.:|:|..|||:..|....:.:|.:..||:||||:.||.:|:..|.|.||:::|.
Mouse    65 LLKGNIGTGLLGLPLAIKNAGIVLGPISLVFIGIISVHCMHILVRCSHFLCQRFKKSTLGYSDTV 129

  Fly   137 EKVFEYGP-KGMRPYSNFAKQFVDIGLMATYYAAACVYIVFIATSFHDV------------INYD 188
            ....|..| ..::..:.:.:..||..|:.|......|||||:|.:...|            ...|
Mouse   130 SFAMEASPWSCLQRQAAWGRSVVDFFLVITQLGFCSVYIVFLAENVKQVHEGFLGSTPIVSNGSD 194

  Fly   189 L-----KINWDVRIYIALTVIPCLLIGQIRDLKWLVPFSMMANIFIVVTFAITLYYMFDEPLVYS 248
            |     :.:.|:|:|:...:...:|:..||:||.|...|.:|||.:..:..|...|:........
Mouse   195 LSHACERRSVDLRVYMLCFLPLIILLVFIRELKNLFVLSFLANISMAASLVIIYQYVVRNMPDPH 259

  Fly   249 DKPLIAKAAHIPLFFATVIFAMEGIGVVMPVENSMRKPQHFLGCPGVLNIAMVTVVSLYAIIGFF 313
            :.|::|.....||||.|.:||.||||||:|:||.||:.:.|   |..|||.|..|..||..:...
Mouse   260 NLPIVAGWKKYPLFFGTAVFAFEGIGVVLPLENQMRESKRF---PQALNIGMAIVTVLYISLATL 321

  Fly   314 GYVRFGDQVRGSITLNLPEGAWLGDTAKLLMAVAILFTFGLQFYVPNEILWRKISHKFSPEKHNI 378
            ||:.|.|:::||||||||:..||..:.|:|.:..|..|:.:|||||.||:...::.:...:...|
Mouse   322 GYMCFRDEIKGSITLNLPQDMWLYQSVKILYSFGIFVTYSIQFYVPAEIIIPGVTARLHAKWKRI 386

  Fly   379 TQILLRSGIILLSGGVAAAIPNLEPFISLVGAVFFSLLGIFVPSFVETVYLWPDRLGVCKWKLVK 443
            .:..:||.::.::...|..||.|:..||.||||..|.|.:.:|..||.:....|...:  |.::|
Mouse   387 CEFGIRSLLVSITCAGAILIPRLDIVISFVGAVSSSTLALILPPLVEILTFSKDHYNI--WMILK 449

  Fly   444 NIFLGVFSILALVAGAVASINEII 467
            ||.:....::..:.|...::.|||
Mouse   450 NISIAFTGVVGFLLGTYVTVEEII 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8785	NP_610804.1	SdaC	60..457	CDD:223884	139/414 (34%)
CG8785	NP_610804.1	SLC5-6-like_sbd	62..463	CDD:294310	140/418 (33%)
Slc36a4	NP_758493.2	SLC5-6-like_sbd	54..469	CDD:294310	140/419 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0814
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2692
OMA	1	1.010	-	-		QHG54358
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000138
OrthoInspector	1	1.000	-	-		mtm8749
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22950
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X121
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.870