DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8785 and SLC38A10

DIOPT Version :9

Sequence 1:	NP_610804.1	Gene:	CG8785 / 36391	FlyBaseID:	FBgn0033760	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	XP_011522590.1	Gene:	SLC38A10 / 124565	HGNCID:	28237	Length:	1134	Species:	Homo sapiens

Alignment Length:	473	Identity:	105/473 - (22%)
Similarity:	181/473 - (38%)	Gaps:	130/473 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 ASAGGALAHLLKSSLGTGILAMPMAFHNAGLAFGMAMTLIVGFLCTH--CVHILVKTSHDICRDA 125
            ||..|.:.:::.|.:|..:|.||..|...|:..| |:.|:.....||  |: .||| |..:.:..
Human     6 ASNWGLITNIVNSIVGVSVLTMPFCFKQCGIVLG-ALLLVFCSWMTHQSCM-FLVK-SASLSKRR 67

  Fly   126 KVSALGFAETAEKVFEYGPKGMRPYSNFAKQFVD---IGLMATYYAAACVYIVFIATSFHDVINY 187
            ..:.||.|.:.:....||..|        |..|:   ||||.....|..|.|..:.::|...: :
Human    68 TYAGLGEAPSPQAFHAYGKAG--------KMLVETSMIGLMLGTCIAFYVVIGDLGSNFFARL-F 123

  Fly   188 DLKINWDVRIYIALTVIPCLLIGQIRDLKWLVPFS----MMANIFIVVTFAITLYYMFDEPLVYS 248
            ..::....|:::...|..|:::          |.|    |||:|......|:..|.:|...:|.|
Human   124 GFQVGGTFRMFLLFAVSLCIVL----------PLSLQRNMMASIQSFSAMALLFYTVFMFVIVLS 178

  Fly   249 -------DKPLIAKAAH---------IPLFFATVIFAMEGIGVVMPVENSMRKPQHFLGCPGVLN 297
                   ....:.:.::         ||:|  .:.||.:  ..|:|..:|:.:|. ......:..
Human   179 SLKHGLFSGQWLRRVSYVRWEGVFRCIPIF--GMSFACQ--SQVLPTYDSLDEPS-VKTMSSIFA 238

  Fly   298 IAMVTVVSLYAIIGFFGYVRFGDQVRGSITLNLP-----EGAWLGDTAKLLMAVAILF------- 350
            .::..|.:.|.::||||||.|.:...|::.::.|     |...:|    .:|:||:.|
Human   239 SSLNVVTTFYVMVGFFGYVSFTEATAGNVLMHFPSNLVTEMLRVG----FMMSVAVGFPMMILPC 299

  Fly   351 ----------------TFGLQFYVPNEILWRKISHKFSPEKHNITQILLRSGIILLSGGVAAAIP 399
                            ||....|:|             |.:.....:.:..|.::  ||:  .||
Human   300 RQALSTLLCEQQQKDGTFAAGGYMP-------------PLRFKALTLSVVFGTMV--GGI--LIP 347

  Fly   400 NLEPFISLVGAVFFSLLGIFVPSFV----------ETVYLWPDRLGVCKWKLVKNIFLGVFSILA 454
            |:|..:.|.||...||:....|:.:          ..|.||              :.|||
Human   348 NVETILGLTGATMGSLICFICPALIYKKIHKNALSSQVVLW--------------VGLGV----- 393

  Fly   455 LVAGAVASINEIIEMYSD 472
            ||...|.:::...|:..|
Human   394 LVVSTVTTLSVSEEVPED 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8785	NP_610804.1	SdaC	60..457	CDD:223884	101/456 (22%)
CG8785	NP_610804.1	SLC5-6-like_sbd	62..463	CDD:294310	103/462 (22%)
SLC38A10	XP_011522590.1	SLC5-6-like_sbd	6..388	CDD:294310	95/429 (22%)
		SdaC	14..404	CDD:223884	100/456 (22%)
		BASP1	488..690	CDD:283191
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0814
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810