DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8785 and SLC36A4

DIOPT Version :9

Sequence 1:	NP_610804.1	Gene:	CG8785 / 36391	FlyBaseID:	FBgn0033760	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_689526.2	Gene:	SLC36A4 / 120103	HGNCID:	19660	Length:	504	Species:	Homo sapiens

Alignment Length:	456	Identity:	151/456 - (33%)
Similarity:	236/456 - (51%)	Gaps:	34/456 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 LTEKELSLTDDPYHP---------FEHRDPNGASAGGALAHLLKSSLGTGILAMPMAFHNAGLAF 95
            :.|:....|.|..|.         ::..|..|.|....|.||||.::|||:|.:|:|..|||:..
Human    27 INEQNFDGTSDEEHEQELLPVQKHYQLDDQEGISFVQTLMHLLKGNIGTGLLGLPLAIKNAGIVL 91

  Fly    96 GMAMTLIVGFLCTHCVHILVKTSHDICRDAKVSALGFAETAEKVFEYGP-KGMRPYSNFAKQFVD 159
            |....:.:|.:..||:||||:.||.:|...|.|.||:::|.....|..| ..::..:.:.:..||
Human    92 GPISLVFIGIISVHCMHILVRCSHFLCLRFKKSTLGYSDTVSFAMEVSPWSCLQKQAAWGRSVVD 156

  Fly   160 IGLMATYYAAACVYIVFIATSFHDVIN--YDLKI---------------NWDVRIYIALTVIP-C 206
            ..|:.|......|||||:|.:...|..  .:.|:               :.|:|||: |..:| .
Human   157 FFLVITQLGFCSVYIVFLAENVKQVHEGFLESKVFISNSTNSSNPCERRSVDLRIYM-LCFLPFI 220

  Fly   207 LLIGQIRDLKWLVPFSMMANIFIVVTFAITLYYMFDEPLVYSDKPLIAKAAHIPLFFATVIFAME 271
            :|:..||:||.|...|.:||:.:.|:..|...|:........:.|::|.....||||.|.:||.|
Human   221 ILLVFIRELKNLFVLSFLANVSMAVSLVIIYQYVVRNMPDPHNLPIVAGWKKYPLFFGTAVFAFE 285

  Fly   272 GIGVVMPVENSMRKPQHFLGCPGVLNIAMVTVVSLYAIIGFFGYVRFGDQVRGSITLNLPEGAWL 336
            |||||:|:||.|::.:.|   |..|||.|..|.:||..:...||:.|.|:::||||||||:..||
Human   286 GIGVVLPLENQMKESKRF---PQALNIGMGIVTTLYVTLATLGYMCFHDEIKGSITLNLPQDVWL 347

  Fly   337 GDTAKLLMAVAILFTFGLQFYVPNEILWRKISHKFSPEKHNITQILLRSGIILLSGGVAAAIPNL 401
            ..:.|:|.:..|..|:.:|||||.||:...|:.||..:...|.:..:||.::.::...|..||.|
Human   348 YQSVKILYSFGIFVTYSIQFYVPAEIIIPGITSKFHTKWKQICEFGIRSFLVSITCAGAILIPRL 412

  Fly   402 EPFISLVGAVFFSLLGIFVPSFVETVYLWPDRLGVCKWKLVKNIFLGVFSILALVAGAVASINEI 466
            :..||.||||..|.|.:.:|..||.:....:...:  |.::|||.:....::..:.|...::.||
Human   413 DIVISFVGAVSSSTLALILPPLVEILTFSKEHYNI--WMVLKNISIAFTGVVGFLLGTYITVEEI 475

  Fly   467 I 467
            |
Human   476 I 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8785	NP_610804.1	SdaC	60..457	CDD:223884	142/415 (34%)
CG8785	NP_610804.1	SLC5-6-like_sbd	62..463	CDD:294310	143/419 (34%)
SLC36A4	NP_689526.2	SLC5-6-like_sbd	58..476	CDD:294310	144/423 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0814
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2692
OMA	1	1.010	-	-		QHG54358
OrthoDB	1	1.010	-	-		D284074at33208
OrthoFinder	1	1.000	-	-		FOG0000138
OrthoInspector	1	1.000	-	-		mtm8520
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22950
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X121
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.880